{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:46:51Z","timestamp":1782798411269,"version":"3.54.5"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy and safety of 3% diquafosol sodium combined with 0.1% fluorometholone for postoperative dry eye in pterygium patients with preoperative tear deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single-center retrospective study included 82 pterygium patients (82 eyes) with preoperative tear deficiency who underwent pterygium excision combined with limbal stem cell transplantation. Patients were divided into an observation group (diquafosol\u202f+\u202ffluorometholone,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f42) and a control group (sodium hyaluronate\u202f+\u202ffluorometholone,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f40). Tear break-up time (BUT), corneal fluorescein staining (CFS) score, Ocular Surface Disease Index (OSDI), Schirmer\n                      <jats:italic>I<\/jats:italic>\n                      test (SIt), and intraocular pressure (IOP) were assessed preoperatively and at 2 and 4\u202fweeks postoperatively. Adverse events and complications were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty patients completed follow-up (41 in observation group, 39 in control group). At 4\u202fweeks postoperatively, the observation group showed significantly longer BUT, lower CFS and OSDI scores, and higher SIt values compared to the control group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). No significant intergroup differences in IOP were observed at any time point. Transient ocular stinging occurred in 2 patients (4.88%) in the observation group, with no severe complications in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot study, the combination of 3% diquafosol sodium and 0.1% fluorometholone showed preliminary evidence of improving tear film stability, repairing ocular surface damage, and alleviating dry eye symptoms in pterygium patients with preoperative tear deficiency, without significantly affecting IOP. Its efficacy appeared superior to sodium hyaluronate combined with fluorometholone. These findings support further investigation in larger, longer-term randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1859002","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:39:39Z","timestamp":1782797979000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["3% diquafosol sodium combined with 0.1% fluorometholone for postoperative dry eye in pterygium patients with preoperative tear deficiency: a pilot retrospective study"],"prefix":"10.3389","volume":"13","author":[{"given":"Qin","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ziyang Central Hospital (West China Hospital of Sichuan University Ziyang Hospital)","place":["Ziyang, Sichuan, China"]},{"name":"The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingde","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ziyang Central Hospital (West China Hospital of Sichuan University Ziyang Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangquan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ziyang Central Hospital (West China Hospital of Sichuan University Ziyang Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ziyang Central Hospital (West China Hospital of Sichuan University Ziyang Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ziyang Central Hospital (West China Hospital of Sichuan University Ziyang Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ziyang Central Hospital (West China Hospital of Sichuan University Ziyang Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ziyang Central Hospital (West China Hospital of Sichuan University Ziyang Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00417-023-06191-1","article-title":"The effect of different pterygium surgery techniques on the ocular surface parameters in different durations: a systematic review and meta-analysis","volume":"262","author":"Chang","year":"2024","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/OPX.0000000000002084","article-title":"The unique properties of tear film breakup process in patients with nasal unilateral pterygium","volume":"101","author":"Chang","year":"2024","journal-title":"Optom Vis Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/ICO.0000000000002575","article-title":"Systematic review: effects of pterygium and Pingueculum on the ocular surface and 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