{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:20:37Z","timestamp":1783059637718,"version":"3.54.6"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic persistent asthma is difficult to control and is often comorbid with obesity. Acupuncture has been shown to reduce airway inflammation and improve lung function, and it may also help regulate body weight to some extent. Currently, obesity combined with chronic persistent asthma is a research hotspot, but interventional studies involving acupuncture remain relatively limited. This study aims to fill this gap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were divided into a control group (conventional western medical treatment) and a treatment group (conventional western medical treatment plus acupuncture). Baseline characteristics between the two groups were compared using univariate analysis. Changes before and after treatment were assessed for pulmonary function indicators (PEF, FEV1, FEV1\/FVC), Asthma Control Test (ACT) scores, Asthma Quality of Life Questionnaire (AQLQ) scores, serum inflammatory markers (IL-17, CRP), and BMI. Multivariate logistic regression and multiple linear regression analyses were conducted to evaluate the effects of treatment modality on asthma control and body weight changes. A response model was constructed to predict asthma control outcomes, and its performance was evaluated using the ROC curve. Further stratified analyses were performed to assess the predictive ability of the model in different subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After treatment, the treatment group showed improvements in pulmonary function, asthma control, quality of life, inflammatory markers, and BMI. Treatment modality was independently associated with asthma control and weight changes. Asthma severity, comorbidities, baseline FEV1, and baseline CRP levels were also associated with asthma control. The response model demonstrated moderate discriminative ability (AUC\u202f=\u202f0.656), with stronger effects observed in patients aged \u226550\u202fyears, males, and those without acute exacerbations in the past year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides a new intervention strategy and supporting evidence for individualized treatment in obese patients with chronic persistent asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1861336","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:40:45Z","timestamp":1783057245000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of acupuncture on asthma control and body weight changes in obese patients with asthma"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhihong","family":"Shi","sequence":"first","affiliation":[{"name":"Mongolian Medical Department, Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Quan","sequence":"additional","affiliation":[{"name":"General Surgery, Xing'an League Mongolian Medicine Hospital","place":["Ulanhot City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Mongolian Medicine, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"Imaging Department, Xilingol League Mongolian Medical Hospital","place":["Xilinhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lai","sequence":"additional","affiliation":[{"name":"Brucellosis, International Mongolian Hospital","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hangjin Banner Mongolian Medical General Hospital","place":["Ordos, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/jcm13195775","article-title":"A review on asthma and allergy: current understanding on molecular perspectives","volume":"13","author":"Gohal","year":"2024","journal-title":"J Clin Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/s0140-6736(22)02125-0","article-title":"Asthma","volume":"401","author":"Porsbjerg","year":"2023","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pccm.2025.02.005","article-title":"Global, regional, and national burden of asthma from 1990 to 2021: a systematic analysis of the global burden of disease study 2021","volume":"3","author":"Mao","year":"2025","journal-title":"Chin Med J Pulm Crit Care Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3760\/cma.j.cn112147-20231024-00266","article-title":"Epidemiology of asthma based on the standard questionnaire","volume":"47","author":"Liu","year":"2024","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"27.e2012006","DOI":"10.5620\/eht.2012.27.e2012006","article-title":"The prevalence of atopic dermatitis, asthma, and allergic rhinitis and the comorbidity of allergic diseases in children","volume":"27","author":"Hong","year":"2012","journal-title":"Environ Health Toxicol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3109\/02813432.2016.1160629","article-title":"Atopic dermatitis, asthma and allergic rhinitis in general practice and the open population: a systematic review","volume":"34","author":"Pols","year":"2016","journal-title":"Scand J Prim Health Care"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.jaci.2018.02.004","article-title":"Obesity and asthma","volume":"141","author":"Peters","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jaip.2015.07.009","article-title":"Hypertension and asthma: a comorbid relationship","volume":"4","author":"Christiansen","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1183\/09059180.00007112","article-title":"Adult-onset asthma: is it really different?","volume":"22","author":"de Nijs","year":"2013","journal-title":"Eur Respir Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"514868","DOI":"10.1155\/2015\/514868","article-title":"Phenotypes, risk factors, and mechanisms of adult-onset asthma","volume":"2015","author":"Ilmarinen","year":"2015","journal-title":"Mediat Inflamm"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.12998\/wjcc.v3.i3.285","article-title":"Asthma and metabolic syndrome: current knowledge and future perspectives","volume":"3","author":"Serafino-Agrusa","year":"2015","journal-title":"World J Clin Cases"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2500\/aap.2019.40.4253","article-title":"Classification of asthma","volume":"40","author":"Padem","year":"2019","journal-title":"Allergy Asthma Proc"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3390\/ph3030514","article-title":"Inhaled corticosteroids","volume":"3","author":"Barnes","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1378\/chest.12-0412","article-title":"The poorly explored impact of uncontrolled asthma","volume":"143","author":"O'Byrne","year":"2013","journal-title":"Chest"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1142\/s0192415x24500010","article-title":"Mechanism of acupuncture in treating obesity: advances and prospects","volume":"52","author":"Wang","year":"2024","journal-title":"Am J Chin Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"103076","DOI":"10.1016\/j.ctim.2024.103076","article-title":"Acupuncture for migraine: a systematic review and meta-regression of randomized controlled trials","volume":"86","author":"Yang","year":"2024","journal-title":"Complement Ther Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"101541","DOI":"10.1016\/j.ctcp.2022.101541","article-title":"Electroacupuncture and acupuncture in the treatment of anxiety - a double blinded randomized parallel clinical trial","volume":"46","author":"Amorim","year":"2022","journal-title":"Complement Ther Clin Pract"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"738","DOI":"10.2174\/1570159x19666210609162809","article-title":"Potential mechanisms and clinical effectiveness of acupuncture in depression","volume":"20","author":"Yang","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1111\/jgh.15645","article-title":"Acupuncture for functional gastrointestinal disorders: a systematic review and meta-analysis","volume":"36","author":"Wang","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"102956","DOI":"10.1016\/j.ctim.2023.102956","article-title":"Clinical evidence for acupuncture for adult asthma: systematic review and meta-analysis of randomised sham\/placebo-controlled trials","volume":"75","author":"Pang","year":"2023","journal-title":"Complement Ther Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41533-023-00330-1","article-title":"Key recommendations for primary care from the 2022 global initiative for asthma (GINA) update","volume":"33","author":"Levy","year":"2022","journal-title":"NPJ Prim Care Respir Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.3760\/cma.j.issn.0254-6450.2019.12.006","article-title":"The cut-off points of body mass index and waist circumference for predicting metabolic risk factors in Chinese adults","volume":"12","author":"Gao","year":"2019","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref23","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed Environ Sci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jaci.2009.06.053","article-title":"The minimally important difference of the asthma control test","volume":"124","author":"Schatz","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2147\/jaa.S462262","article-title":"Research on the mechanism and application of acupuncture therapy for asthma: a review","volume":"17","author":"Wang","year":"2024","journal-title":"J Asthma Allergy"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/340126","article-title":"Acupuncture attenuated inflammation and inhibited Th17 and Treg activity in experimental asthma","volume":"2015","author":"Wei","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1038\/s41366-025-01871-w","article-title":"Effect of vagus nerve stimulation on metabolism: a systematic review and meta-analysis","volume":"49","author":"Shen","year":"2025","journal-title":"Int J Obes"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"17469","DOI":"10.3390\/ijms160817469","article-title":"Interleukin-17A gene expression in morbidly obese women","volume":"16","author":"Zapata-Gonzalez","year":"2015","journal-title":"Int J Mol Sci"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1861336\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:40:47Z","timestamp":1783057247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1861336\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":28,"alternative-id":["10.3389\/fmed.2026.1861336"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1861336","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"article-number":"1861336"}}