{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:34:03Z","timestamp":1786516443110,"version":"build-2736575974"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the differences in mitral valve (MV) structure in adult patients with atrial septal defect (ASD) by transesophageal echocardiography (TEE) and explore the clinical value of these differences in surgical repair for mitral valves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data related to the mitral valve from 75 adult patients who underwent surgical repair were collected which formed the observation group. The corresponding data from 63 adult patients with normal intracardiac structures and minimal or no mitral regurgitation were collected. The structural differences of the mitral valve between the two groups compared, and ASD-MV based on the degree of these differences were classified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were significant differences in the morphology and structure of the mitral valve between the observation group and the control group. Statistical analysis revealed significant differences in ASD area, Qp\/Qs ratio(the ratio of pulmonary to systemic blood flow), and mitral valve anterior leaflet length across ASD-MV subtypes (all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study classified the mitral valve in patients with ASD to assist in determining whether concurrent mitral valve repair is indicated. It significantly reduced the proportion of patients with markedly aggravated mitral regurgitation post-ASD repair, providing a reference for concurrent mitral valve intervention in ASD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1861780","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:20:28Z","timestamp":1786515628000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel echocardiographic classification of mitral valve structure in atrial septal defect of adult and its value on surgical repair for mitral valve"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuxi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chennian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1093\/eurheartj\/ehab646","article-title":"Atrial septal defect in adulthood: a new paradigm for congenital heart disease.","volume":"43","author":"Brida","year":"2022","journal-title":"Eur Heart J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.amjcard.2015.04.042","article-title":"Fate of mitral regurgitation after transcatheter closure of atrial septal defect in 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