{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:08:41Z","timestamp":1784268521731,"version":"3.55.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to compare the effects of alfentanil and sufentanil on cough response during tracheal extubation in patients undergoing suspension laryngoscopy surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, randomized controlled trial, 80 patients (ASA I\u2013II) scheduled for elective suspension laryngoscopy were enrolled. Patients were randomly allocated to receive either alfentanil (Group A,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f42; The induction dose for general anesthesia is 21\u202f\u03bcg\/kg, and maintenance 0.7\u20131.4\u202f\u03bcg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00b7min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) or sufentanil (Group S,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f38; The induction dose for general anesthesia is 0.3\u202f\u03bcg\/kg, and maintenance 0.01\u20130.02\u202f\u03bcg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00b7min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), both combined with propofol 2\u20134\u202f\u03bcg\u00b7mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      target-controlled infusion. The primary outcome was the incidence of cough, including moderate-to-severe cough within 5\u202fmin after tracheal extubation. Secondary outcomes included cough during induction, hemodynamic variables, extubation time, recovery scores, postoperative pain, and adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of cough within 5\u202fmin after tracheal extubation was significantly higher in Group A than in Group S (69.0% [29\/42] vs. 44.7% [17\/38]; OR 2.76, 95%CI 1.08\u20137.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03), whereas the incidence of moderate-to-severe cough did not differ between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). During induction, cough occurred less frequently in Group A (11.9% [5\/42] vs. 31.6% [12\/38]; OR 0.29, 95%CI 0.10\u20130.89;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.03). Heart rate and mean arterial pressure were lower in Group A at specific intraoperative time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Extubation time, Aldrete scores, and postoperative pain scores were comparable between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). No opioid-related adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In suspension laryngoscopy surgery, alfentanil is associated with a lower incidence of cough during induction but a higher incidence of cough during extubation compared with sufentanil. There was no statistically significant difference in the incidence of moderate-to-severe cough between alfentanil and sufentanil.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1863301","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:43:30Z","timestamp":1784267010000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of alfentanil and sufentanil on extubation-related cough following suspension laryngoscopy surgery: a randomized controlled trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Qiang","family":"Wei","sequence":"first","affiliation":[{"name":"Anesthesiology Operating Center, West China Hospital of Sichuan University\u2013Ziyang Hospital (Ziyang Central Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaman","family":"Li","sequence":"additional","affiliation":[{"name":"Anesthesiology Operating Center, West China Hospital of Sichuan University\u2013Ziyang Hospital (Ziyang Central Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Shao","sequence":"additional","affiliation":[{"name":"Anesthesiology Operating Center, West China Hospital of Sichuan University\u2013Ziyang Hospital (Ziyang Central Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Anesthesiology Operating Center, West China Hospital of Sichuan University\u2013Ziyang Hospital (Ziyang Central Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Anesthesiology Operating Center, West China Hospital of Sichuan University\u2013Ziyang Hospital (Ziyang Central Hospital)","place":["Ziyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1177\/0194599813495372","article-title":"Does topical anesthesia using aerosolized lidocaine inhibit the superior laryngeal nerve reflex?","volume":"149","author":"Arslan","year":"2013","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e102946","DOI":"10.5812\/aapm.102946","article-title":"Comparison of sedation with dexmedetomidine-alfentanil versus ketamine-alfentanil in patients undergoing closed reduction of nasal 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