{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:19:56Z","timestamp":1783423196714,"version":"3.54.6"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Sympathetic ophthalmia (SO) is a rare but serious inflammatory ocular disorder. We report a case of endogenous fungal endophthalmitis caused by\n                      <jats:italic>Aspergillus flavus<\/jats:italic>\n                      infection, which resulted in SO in the contralateral eye after two vitrectomy procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>\n                      A 22-year-old man presented to our hospital with a 2-week history of redness and blurred vision in his right eye. Three months earlier, he had undergone two vitrectomy procedures for fungal endophthalmitis in his left eye, with culture results positive for\n                      <jats:italic>Aspergillus flavus<\/jats:italic>\n                      . Upon admission, antifungal therapy was administered; however, his health condition did not improve and progressively deteriorated. Metagenomic sequencing and microbial culture of intraocular fluid from the right eye revealed no fungi. Multimodal imaging, including optical coherence tomography (OCT), ocular B-scan ultrasonography, fundus examination, and indocyanine green angiography (ICGA), supported a definitive diagnosis of sympathetic ophthalmia. Treatment with prednisone and adalimumab stabilized the patient\u2019s condition. During the 13-month follow-up period, the patient\u2019s best-corrected visual acuity (BCVA) was 1.0 in the right eye and 0.04 in the left eye, with no observed recurrences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sympathetic ophthalmia is a complex ocular disorder characterized by diverse clinical and imaging features, making early diagnosis and treatment challenging. This case underscores the importance of timely intervention and aggressive therapeutic strategies for managing this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1863685","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:10:36Z","timestamp":1783422636000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sympathetic ophthalmia induced by vitrectomy for endogenous fungal endophthalmitis: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiao-Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Ophthalmic Hospital Affiliated to Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"Ophthalmic Hospital Affiliated to Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-E.","family":"Gao","sequence":"additional","affiliation":[{"name":"Ophthalmic Hospital Affiliated to Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Ophthalmic Hospital Affiliated to Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wen","sequence":"additional","affiliation":[{"name":"Ophthalmic Hospital Affiliated to Shandong University of Traditional Chinese Medicine","place":["Jinan, China"]},{"name":"Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Shandong Academy of Eye Disease Prevention and 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