{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:03:32Z","timestamp":1785301412976,"version":"3.55.0"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultra-high dose rate FLASH radiotherapy (FLASH-RT) holds the potential to revolutionize oncology by dramatically sparing normal tissue while maintaining tumor control. To capture both physical breakthroughs and biomedical translation, this study provides a comprehensive bibliometric mapping to evaluate the global research landscape and translational frontiers of FLASH-RT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To ensure maximum comprehensiveness, a systematic dual-database retrieval was conducted using the Web of Science Core Collection (WoSCC) and PubMed for articles published between January 1, 2014, and December 31, 2025. Following software-assisted deduplication using bibliometrix and independent, researcher-guided manual screening to exclude non-relevant document types, analytical protocols utilizing the R package bibliometrix, VOSviewer, and CiteSpace were applied to visualize publication trends, co-authorship networks, and keyword bursts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A final analytical cohort of 807 high-quality articles was identified, revealing a rapidly accelerating, non-linear growth pattern relative to the 2014 baseline, with a marked surge after 2021, corresponding to the onset of prospective human FLASH-RT trials. The fitted annual-output trend followed a quadratic polynomial model with R\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.9458. The United States (30.4%) and China (18.7%) led quantitatively, while Switzerland drove deep multi-institutional innovation. We identified a definitive interdisciplinary paradigm shift: early investigations focused on fundamental physics and X-ray dosimetry, whereas contemporary research has rapidly pivoted toward proton FLASH therapy, oxygen depletion kinetics, and phase-1 clinical workflows. Furthermore, keyword burst detection highlighted \u201cion recombination\u201d and \u201cdelivery methods\u201d as the most critical ongoing technical challenges.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>By integrating extensive data from both WoSCC and PubMed, this study documents the safety-led maturation of FLASH-RT from an experimental physics curiosity to a viable clinical precision tool. The evolving synergy between dose-rate optimization and clinical oncology emphasizes that solving real-time dosimetric challenges remains the essential frontier for achieving widespread clinical adoption and widening the therapeutic window.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1864006","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:45:22Z","timestamp":1785300322000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global clinical landscape and multidisciplinary translational frontiers of FLASH radiotherapy: a systematic review and visualized bibliometric mapping based on WoSCC and PubMed (2014\u20132025)"],"prefix":"10.3389","volume":"13","author":[{"given":"Yupeng","family":"Di","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Air Force Medical Center, Fourth Military Medical University","place":["Beijing, China"]},{"name":"Department of Radiation Protection Medicine, School of Preventive Medicine, Fourth Military Medical University","place":["Xi\u2019an, China"]},{"name":"Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment","place":["Xi'an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Air Force Medical Center, Fourth Military Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Air Force Medical Center, Fourth Military Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boning","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Senior Department of Oncology, The First Medical Center of PLA General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Senior Department of Oncology, The First Medical Center of PLA General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1576227","DOI":"10.3389\/fphy.2025.1576227","article-title":"Dosimetry characteristics of ultra-high dose rate X-ray: a short review","volume":"13","author":"Tao","year":"2025","journal-title":"Front Phys"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1201708","DOI":"10.3389\/fphy.2023.1201708","article-title":"An insight into hypothesized biological mechanisms contributing to the flash effect","volume":"11","author":"Del 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