{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:27:50Z","timestamp":1786429670429,"version":"build-2736575974"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare the efficacy and incidence of adverse reactions of oliceridine versus sufentanil in patient-controlled intravenous analgesia (PCIA) for postoperative pain management following gynecological laparoscopic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, double-blind trial, 152 patients undergoing elective gynecological laparoscopic surgery were randomly assigned to receive PCIA with either oliceridine (Group O, 0.4\u202fmg\/kg, n\u202f=\u202f76) or sufentanil (Group S, 2\u202f\u03bcg\/kg, n\u202f=\u202f76). The primary outcome was the Visual Analog Scale (VAS) score at rest at 2, 4, 8, 12, 18, 24, 36, and 48\u202fh postoperatively. Secondary outcomes included postoperative Mini-Mental State Examination (MMSE) scores, number of PCIA demands, rescue analgesic use, adverse events, time to first flatus and defecation, patient satisfaction, and length of hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Resting VAS scores were comparable between groups except at 4\u202fh (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). No significant differences were observed in MMSE scores, PCIA demands, rescue analgesia, time to first defecation, or other adverse events (pruritus, dizziness, fever, headache, cough, and abdominal distension) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). Group O had higher body weight and body mass index (BMI) than Group S (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.028 and\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.041, respectively). Group O demonstrated lower postoperative nausea and vomiting (PONV) incidence (19.48% vs. 36.14%; relative risk (RR), 0.54; 95% confidence interval (CI), 0.32\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.019), prolonged time to first flatus (27.16\u202f\u00b1\u202f9.33\u202fh vs. 23.23\u202f\u00b1\u202f9.36\u202fh;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.014), and higher patient satisfaction (4.09\u202f\u00b1\u202f0.81 vs. 3.74\u202f\u00b1\u202f0.72;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For postoperative analgesia following gynecological laparoscopic surgery, oliceridine provides effective analgesia comparable to sufentanil while significantly reducing the risk of opioid-related PONV, demonstrating a favorable safety profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>http:\/\/www.chictr.org.cn\/<\/jats:uri>\n                      , ChiCTR2400089648.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1866393","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:35:25Z","timestamp":1786426525000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of oliceridine versus sufentanil for patient-controlled intravenous analgesia following gynecological laparoscopic surgery: a randomized, double-blind, parallel-group trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Jingmei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]},{"name":"Department of Anesthesiology, Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangbo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]},{"name":"Department of Anesthesiology, Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]},{"name":"Department of Anesthesiology, Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]},{"name":"Department of Anesthesiology, Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]},{"name":"Department of Anesthesiology, Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]},{"name":"Department of Anesthesiology, Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xukeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingcong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1213\/01.ANE.0000068822.10113.9E","article-title":"Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged","volume":"97","author":"Apfelbaum","year":"2003","journal-title":"Anesth Analg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2147\/JPR.S144066","article-title":"Poorly controlled postoperative pain: prevalence, consequences, and prevention","volume":"10","author":"Gan","year":"2017","journal-title":"J Pain Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1016\/S0140-6736(03)14966-5","article-title":"Anaesthesia, surgery, and challenges in postoperative 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