{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:08:04Z","timestamp":1789103284294,"version":"build-2803163510"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV) infection may cause psychological distress and strain intimate relationships because concerns regarding transmission, stigma, and cancer risk can affect both patients and their partners. Evidence regarding HPV- specific couple-based psychosocial interventions remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of a couple-based dyadic coping intervention on psychological distress and relationship functioning in patients with HPV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial enrolled 148 couples from a special-needs outpatient department, with the female partner in each couple diagnosed with HPV infection. Couples were randomly assigned in a 1:1 ratio to receive either an 8-week couple-based dyadic coping intervention plus routine care or routine care alone. The primary outcome was the change in the patient-reported Depression Anxiety Stress Scale-21 (DASS-21) total score from baseline to 8\u202fweeks. Secondary outcomes included the HPV Impact Profile (HIP) total score and the patient- and spouse-reported Couples\u2019 Illness Communication Scale (CICS), Dyadic Adjustment Scale (DAS), and Dyadic Coping Inventory (DCI) total scores. Follow-up compliance and HPV clearance were evaluated as exploratory outcomes. Between-group differences in changes were reported with 95% confidence intervals and Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      , and the robustness of the primary finding was further examined using multivariable ANCOVA and multiple imputation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 142 couples completed the 8-week assessment (intervention group,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f72; control group,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f70). The intervention group showed a greater reduction in the DASS-21 total score than the control group (difference in change, \u22124.98 points; 95% CI, \u22127.51 to \u22122.45; Cohen\u2019s\n                      <jats:italic>d<\/jats:italic>\n                      \u202f=\u202f\u22120.65;\n                      <jats:italic>p\u202f&amp;lt;<\/jats:italic>\n                      0.001). The adjusted ANCOVA and multiple-imputation sensitivity analysis yielded consistent findings. Secondary total-score outcomes also favored the intervention, with absolute standardized effect sizes ranging from 0.68 to 0.89 (all Holm-adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Complete follow-up compliance was higher in the intervention group than in the control group (75.0% vs. 45.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.001). HPV clearance at 3\u202fmonths was numerically higher in the intervention group (38.9% vs. 24.3%), but the between-group difference was not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.062). No serious adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An 8-week couple-based dyadic coping intervention was associated with short-term improvements in psychological distress, HPV-specific impact, relationship functioning, dyadic coping, and follow-up compliance. The intervention shows promise as a supportive psychosocial approach but warrants confirmation in larger multicenter studies with longer follow-up before routine clinical implementation. The HPV clearance finding should be considered exploratory and hypothesis-generating.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1867371","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:36:23Z","timestamp":1789101383000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a couple-based dyadic coping intervention on psychological distress and relationship functioning in HPV patients: a randomized controlled trial in China"],"prefix":"10.3389","volume":"13","author":[{"given":"Die","family":"Hou","sequence":"first","affiliation":[{"name":"Department of VIP Clinic Nursing, West China Second University Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University)","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Public Health Clinical Center of Chengdu","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qionglai Medical Center Hospital","place":["Qionglai, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of VIP Clinic Nursing, West China Second University Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University)","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2478\/fco-2019-0014","article-title":"Current trends in the management and prevention of human papillomavirus (HPV) infection","volume":"25","author":"Ntanasis-Stathopoulos","year":"2020","journal-title":"J BUON"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jiph.2023.02.014","article-title":"Human papillomavirus in cancer: infection, disease transmission, and progress in vaccines","volume":"16","author":"Oyouni","year":"2023","journal-title":"J Infect Public Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"469580221150094","DOI":"10.1177\/00469580221150094","article-title":"Challenges and needs of HPV-positive 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