{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:57Z","timestamp":1789448577498,"version":"build-2803163510"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Giant cell tumor of bone (GCTB) is a benign but locally aggressive primary bone tumor that frequently affects the epiphyseal\u2013metaphyseal region of long bones, particularly around the knee. In rare cases, it may undergo malignant trans-formation or metastasize.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 62-year-old woman with a 5-year history of left knee pain, progressive deformity, and functional limitation. Imaging studies and biopsy confirmed a giant cell tumor of the proximal tibia with extensive epiphyseal involvement and articular collapse. The patient underwent oncologic resection using patient-specific cutting guides, followed by reconstruction with a custom 3D-printed porous trabecular Ti6Al4V-ELI implant manufactured by selective laser melting on a Renishaw AM400 system, combined with hinged total knee arthroplasty. The extensor mechanism was reinserted through dedicated fixation slots, and soft-tissue coverage was achieved with a medial gastrocnemius flap and polypropylene mesh. At 6 months, radiographs showed satisfactory alignment and early structural integration, with no evidence of local recurrence or implant loosening. Clinically, the patient achieved full weight-bearing and an excellent functional outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case suggests that patient-specific reconstruction combining virtual planning, 3D printing, and porous trabecular design may be a feasible limb-salvage option for selected proximal tibial GCTB with major osteoarticular destruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1868738","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:26:57Z","timestamp":1789446417000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient-specific osteoarticular reconstruction of the proximal tibia for giant cell tumor using a 3D-printed trabecular implant and hinged knee arthroplasty: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Mauricio","family":"Olmedo-L\u00f3pez","sequence":"first","affiliation":[{"name":"Orthopedic Surgery Resident, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, University of Buenos Aires","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Damian Belzino","sequence":"additional","affiliation":[{"name":"Specialist in Orthopedic Surgery, Specialist in Orthopedic Oncology, Staff Physician, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, University of Buenos Aires","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"P\u00e9rez-Soliz","sequence":"additional","affiliation":[{"name":"Specialist in Orthopedic Surgery, Foot and Ankle Fellowship, Trauma Center, Hospital de Cl\u00ednicas Jos\u00e9 de San Mart\u00edn, University of Buenos Aires","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Vasconez-Gonzalez","sequence":"additional","affiliation":[{"name":"One Health Research Group, Universidad de Las Am\u00e9ricas","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny K.","family":"Tupiza-Luna","sequence":"additional","affiliation":[{"name":"Departamento de Traumatologia y Ortopedia, Hospital Pablo Arturo Suarez","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galo S.","family":"Guerrero-Castillo","sequence":"additional","affiliation":[{"name":"One Health Research Group, Universidad de Las Am\u00e9ricas","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan S.","family":"Izquierdo-Condoy","sequence":"additional","affiliation":[{"name":"One Health Research Group, Universidad de Las Am\u00e9ricas","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Ortiz-Prado","sequence":"additional","affiliation":[{"name":"One Health Research Group, Universidad de Las Am\u00e9ricas","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","article-title":"Giant cell tumor (osteoclastoma)","volume-title":"StatPearls [Internet]","author":"Hosseinzadeh","year":"2025"},{"key":"B2","doi-asserted-by":"publisher","first-page":"Article_12","DOI":"10.7547\/19-030","article-title":"Can giant cell tumor of the bone occur in the skeletally immature?","volume":"110","author":"Haseeb","year":"2020","journal-title":"J Am Podiatr Med Assoc"},{"key":"B3","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2022::AID-CNCR6>3.0.CO;2-Y","article-title":"Giant cell tumor of the bones of the hand and 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