{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:41:50Z","timestamp":1790959310628,"version":"4.1.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The feasibility of magnetically controlled capsule gastroscopy (MCCG) as an alternative diagnostic tool, along with a sequential serology\u2014MCCG protocol, needs to be assessed for its effectiveness in detecting high-risk events associated with gastric cancer development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Health check-up records were collected between 2019 and 2020. Asymptomatic individuals underwent MCCG and relevant serologic examinations, which included tests for pepsinogen-I (PG-I), pepsinogen-II (PG-II), gastrin-17, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9). The major outcomes from MCCG included tumors and high-risk events, specifically chronic atrophic gastritis (CAG), gastric ulcer, and gastric polyps. The detection rate of MCCG was estimated, and the predictive strength of serology for MCCG findings was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1,432 eligible healthy individuals undergoing routine health check-ups were included. MCCG detected no tumors, but identified 114 cases with at least one high-risk event. The overall detection rate was 79.6 per 1,000 persons for all high-risk events with specific detection rates for CAG, ulcer, and polyps being 15.4, 14.7, and 55.2 per 1,000 persons, respectively. Older individuals showed significantly higher rates of high-risk events (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), particularly among those aged 60\u202fyears and older. In the MCCG-detected CAG outcome dataset, serum levels of PG-I and the PG-I\/-II ratio were significantly lower in the CAG group. Although the serologic tests did not effectively detect all high-risk events (AUC\u202f&amp;lt;\u202f0.6, SEN\u202f&amp;lt;\u202f15%), they exhibited excellent specificity (SPE\u202f&amp;gt;\u202f90%). However, serologic CAG had a significant association with MCCG-detected CAG (adjusted diagnostic odds ratio\u202f=\u202f10.40, 95% CI 2.08\u201351.98), despite demonstrating poor diagnostic strength (AUC\u202f=\u202f0.555, SEN\u202f=\u202f12.5%, SPE\u202f=\u202f98.6%, PLR\u202f=\u202f8.85, NLR\u202f=\u202f0.89). The other serologic tests did not show significant associations or rational interpretation with MCCG findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCCG has acceptable detection rates for high-risk events associated with gastric cancer. However, as an alternative diagnostic tool, it lacks biopsy capability, which requires sequential flexible gastroscopy for suspicious lesions. Serologic CAG was significantly associated with MCCG-detected CAG and demonstrated high specificity, suggesting its potential utility in a screening algorithm. Both the screening efficacy of MCCG and the cost-effectiveness of sequential serology-MCCG protocol require further prospective investigation against an appropriate reference standard.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1874613","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:28:20Z","timestamp":1787027300000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Serology and magnetically controlled capsule gastroscopy for opportunistic screening of high-risk events in gastric cancer development: a cross-sectional study"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuan","family":"Yang","sequence":"first","affiliation":[{"name":"Gastric Cancer Center, Department of General Surgery, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Department of Gastrointestinal and Hernia Surgery, Second People's Hospital of Yibin City (West China Yibin Hospital, Sichuan University)","place":["Yibin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Yao","family":"Wen","sequence":"additional","affiliation":[{"name":"Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Chen","family":"Zou","sequence":"additional","affiliation":[{"name":"Gastric Cancer Center, Department of General Surgery, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Department of General Surgery, Second People's Hospital of Yibin City (West China Yibin Hospital, Sichuan University)","place":["Yibin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Zu","family":"Chen","sequence":"additional","affiliation":[{"name":"Gastric Cancer Center, Department of General Surgery, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Ya'an Cancer Prevention and Control Center, Ya'an People's Hospital (West China Ya'an Hospital, Sichuan University)","place":["Ya\u2019an, China"]},{"name":"Ya'an Key Laboratory for High Altitude Medicine, Ya'an People's Hospital (West China Ya'an Hospital, Sichuan University)","place":["Ya\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.clinre.2014.04.014","article-title":"High mortality from hepatic, gastric and esophageal cancers in mainland China: 40 years of experience and development","volume":"38","author":"Wang","year":"2014","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1016\/s0140-6736(16)31967-5","article-title":"Improvement of cancer control in mainland China: epidemiological profiles during the 2004\u201310 National Cancer Prevention and control program","volume":"388","author":"Chen","year":"2004","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.jare.2024.11.028","article-title":"Trends, clinicopathological features, surgical treatment patterns and prognoses of early-onset versus late-onset gastric cancer: a retrospective cohort study","volume":"75","author":"Liu","year":"2025","journal-title":"J Adv Res"},{"key":"ref4","first-page":"24","article-title":"National trend of gastric cancer mortality in China (2003-2015): a population-based study","volume-title":"Cancer Commun (Lond)","author":"Gao","year":"2019"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s12032-014-0315-y","article-title":"A difficulty in improving population survival outcome of gastric cancer in mainland China: low proportion of early diseases","volume":"31","author":"Chen","year":"2014","journal-title":"Med Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"44660","DOI":"10.18632\/oncotarget.9378","article-title":"Strategies to improve treatment outcome in gastric cancer: a retrospective analysis of patients from two high-volume hospitals in Korea and China","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.14309\/ajg.0000000000001757","article-title":"Tibetan ethnicity, birthplace, Helicobacter pylori infection, and gastric Cancer risk","volume":"117","author":"Wang","year":"2022","journal-title":"Am J 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