{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:18:50Z","timestamp":1783491530186,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Dermatomyositis (DM) is a rare autoimmune disease, and its subtypes exhibit considerable heterogeneity in perioperative risk. The anti-transcription intermediary factor 1-gamma (TIF1-\u03b3) antibody\u2013positive subtype is particularly associated with an increased risk of underlying malignancy and poses unique anesthetic challenges because of its potential multisystem involvement. We report the perioperative anesthetic management of a 47-year-old woman with TIF1-\u03b3 antibody\u2013positive DM complicated by breast cancer who underwent a modified radical mastectomy. The patient presented with classic cutaneous manifestations, proximal myopathy, and oropharyngeal dysphagia. Comprehensive pre-operative anesthetic assessment and meticulous perioperative management contributed to an uneventful surgical course and favorable outcome. This case highlights the marked clinical heterogeneity of DM subtypes and the corresponding differences in perioperative anesthetic risk. It also underscores the importance of recognizing the potential multisystem involvement of DM in patients undergoing anesthesia. Thorough pre-operative evaluation and individualized anesthetic management are therefore essential for optimizing perioperative outcomes.<\/jats:p>","DOI":"10.3389\/fmed.2026.1876664","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:57:43Z","timestamp":1783490263000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative management of anti\u2013TIF1-\u03b3 dermatomyositis in a patient with breast cancer: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"YaQian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["HangZhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuTing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["HangZhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["HangZhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S1474-4422(25)00233-9","article-title":"Advances in the classification and management of idiopathic inflammatory myopathies","volume":"24","author":"Joost","year":"2025","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41572-021-00325-7","article-title":"Idiopathic inflammatory myopathies","volume":"7","author":"Ingrid","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"B3","doi-asserted-by":"publisher","first-page":"107413","DOI":"10.1016\/j.medcli.2026.107413","article-title":"Clinical characteristics and factors associated with dysphagia in idiopathic inflammatory myopathy: a cross-sectional observational study","volume":"166","author":"Pei","year":"2026","journal-title":"Med Clin."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e0154746","DOI":"10.1371\/journal.pone.0154746","volume":"11","author":"Mugii","year":"2016","journal-title":"Oropharyngeal dysphagia in dermatomyositis: associations with clinical and laboratory features including autoantibodies. 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