{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:13:42Z","timestamp":1783660422725,"version":"3.55.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    The diagnosis of functional gastrointestinal disorders, now conceptualized as disorders of gut\u2013brain interaction (DGBI), has long relied on symptom-based criteria. Gastrointestinal endoscopy, meanwhile, has been largely confined to the exclusion of organic pathology. This exclusionary logic has led to a systematic underestimation of the diagnostic value embedded in endoscopically normal findings. Here we propose a fundamental repositioning of the endoscope from a static morphological exclusion tool into a dynamic physiological assessment platform. By integrating real-time intraluminal functional imaging, optical biopsy of mucosal microarchitecture, neuro-immune fluorescence molecular imaging, and intraluminal environmental monitoring, this platform enables the\n                    <jats:italic>in situ<\/jats:italic>\n                    capture of key pathophysiological parameters\u2014including gastrointestinal sensorimotor function, mucosal barrier integrity, and immune activation status. Establishing such a \u201cfunctional endoscopy\u201d assessment framework may help bridge the traditional divide between structural and functional disease. It could also facilitate future precision endoscopic phenotyping of DGBI based on underlying pathophysiological mechanisms.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1878949","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:24:39Z","timestamp":1783657479000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal endoscopy for physiological assessment in functional gastrointestinal disorders: a perspective"],"prefix":"10.3389","volume":"13","author":[{"given":"Jing-rong","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Endoscopy, The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-shan","family":"Guo","sequence":"additional","affiliation":[{"name":"Finance Office, The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Discipline Inspection Commission Office, The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-shuang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e00278","DOI":"10.14309\/ctg.0000000000000278","article-title":"Rome III, Rome IV, and potential Asia symptom criteria for functional dyspepsia do not reliably distinguish functional from organic 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