{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:00:36Z","timestamp":1785128436114,"version":"3.55.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) and myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) are chronic, debilitating disorders characterized by substantial symptom burden, impaired quality of life, and high healthcare utilization. IBS is a disorder of gut\u2013brain interaction with a global prevalence ranging from 3.8% to 9.2%, while ME\/CFS is defined by persistent, exertion-intolerant fatigue and multisystem dysfunction. Growing evidence suggests frequent co-occurrence of these conditions, implicating shared mechanisms such as immune dysregulation, autonomic imbalance, and altered gut\u2013brain signaling. However, the magnitude of their association has not been comprehensively quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review and meta-analysis by searching Embase, PubMed, Scopus, and Google Scholar databases from inception through February 2026. Eligible observational studies reporting associations or prevalence between IBS and ME\/CFS were included. Random-effects meta-analyses were performed to pool odds ratios (ORs) and prevalence estimates. Heterogeneity was assessed using I\n                      <jats:sup>2<\/jats:sup>\n                      statistics. We evaluated for publication bias and assessed for risk of bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-two studies were included in the systematic review and 18 in the meta-analysis. Individuals with ME\/CFS had significantly higher odds of IBS compared with controls (OR\u202f=\u202f7.20; 95% CI: 2.77\u201318.76; I\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f72.1%). The pooled prevalence of IBS among individuals with ME\/CFS was 37% (95% CI: 23\u201354%), with substantial heterogeneity (I\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f99.5%). Subgroup analysis revealed that diagnostic criteria significantly influenced prevalence (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.0001), while meta-regression identified ME\/CFS diagnostic criteria as a significant moderator.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IBS and ME\/CFS are strongly associated, suggesting shared underlying mechanisms. These findings support integrated screening approaches and coordinated, multidisciplinary management to improve outcomes in affected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420251006255<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1881784","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:25:45Z","timestamp":1785126345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between myalgic encephalomyelitis\/chronic fatigue syndrome and irritable bowel syndrome: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Natalie","family":"Rajabi","sequence":"first","affiliation":[{"name":"Department of Public Health and Preventive Medicine, St. George\u2019s University School of Medicine","place":["St. George, Grenada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash V. 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