{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:44:40Z","timestamp":1785908680776,"version":"3.56.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Fragility fractures are a major clinical and public health challenge in aging societies. Current prevention strategies are commonly organized around skeletal risk assessment and osteoporosis management, yet fracture occurrence and post-fracture outcomes in older adults are also influenced by muscle dysfunction, frailty, fall propensity, physiological reserve, and rehabilitation capacity. This Perspective proposes a bone\u2013muscle\u2013function framework to complement existing osteoporosis-centered approaches to fragility fracture prevention. In this framework, bone represents skeletal strength and structural fragility, muscle represents sarcopenia-related impairment in strength and physical performance, and function represents frailty-related reserve, resilience, fall propensity, and recovery capacity. Osteosarcopenia provides the bone\u2013muscle foundation, whereas the addition of function extends the framework to include broader vulnerability and recovery potential. Rather than simply adding frailty and sarcopenia to osteoporosis assessment, it organizes bone, muscle, and function into a staged framework for risk identification, recovery planning, and secondary prevention.<\/jats:p>","DOI":"10.3389\/fmed.2026.1881899","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:49:39Z","timestamp":1785905379000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond bone density: toward an integrated bone\u2013 muscle\u2013function framework for fragility fracture prevention"],"prefix":"10.3389","volume":"13","author":[{"given":"Shengzhu","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Wuchang Hospital Affiliated to Wuhan University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, The University of Sydney","place":["Camperdown, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyao","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Wuchang Hospital Affiliated to Wuhan University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Wuchang Hospital Affiliated to Wuhan University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1001\/jama.2025.6003","article-title":"Osteoporosis: a review","volume":"334","author":"Morin","year":"2025","journal-title":"JAMA."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/S0140-6736(25)01385-6","article-title":"Osteoporosis","volume":"406","author":"Ye","year":"2025","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/jbmr.4821","article-title":"Global epidemiology of hip fractures: secular trends in incidence rate, post-fracture treatment, and all-cause mortality","volume":"38","author":"Sing","year":"2023","journal-title":"J Bone Mineral Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s11657-025-01551-2","article-title":"Recommendations for the prevention of fragility fractures: a consensus from international experts and Ibero-American scientific societies","volume":"20","author":"S\u00e1ez-L\u00f3pez","year":"2025","journal-title":"Arch Osteoporos."},{"key":"B5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.11005\/jbm.2023.30.2.149","article-title":"Position statement: exercise guidelines for osteoporosis management and fall prevention in osteoporosis patients","volume":"30","author":"Bae","year":"2023","journal-title":"J Bone Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician's guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/medsci13030089","article-title":"Hip fracture as a systemic disease in older adults: a narrative review on multisystem implications and management","volume":"13","author":"Andaloro","year":"2025","journal-title":"Med Sci (Basel)."},{"key":"B8","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1007\/s00774-022-01334-6","article-title":"Sarcopenia: an unsolved problem after hip fracture","volume":"40","author":"Park","year":"2022","journal-title":"J Bone Miner Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.3390\/nu16111773","article-title":"Nutrition, vitamin D, and calcium in elderly patients before and after a hip fracture and their impact on the musculoskeletal system: a narrative review","volume":"16","author":"Cianferotti","year":"2024","journal-title":"Nutrients."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.12771\/emj.2025.00801","article-title":"Hip fracture and cognitive impairment in older adults\u2013integrated approaches to rehabilitation: a narrative review","volume":"48","author":"Lim","year":"2025","journal-title":"Ewha Med J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1056\/NEJMra2301292","article-title":"Frailty in older adults","volume":"391","author":"Kim","year":"2024","journal-title":"N Engl J Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing."},{"key":"B13","doi-asserted-by":"publisher","first-page":"155638","DOI":"10.1016\/j.metabol.2023.155638","article-title":"Sarcopenia, osteoporosis and frailty","volume":"145","author":"Gielen","year":"2023","journal-title":"Metabolism."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1577758","DOI":"10.3389\/fendo.2025.1577758","article-title":"Osteosarcopenia: epidemiology, molecular mechanisms, and management","volume":"16","author":"Yi","year":"2025","journal-title":"Front Endocrinol (Lausanne)."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s00198-025-07503-3","article-title":"Comparison of the time-dependent discriminatory accuracy of femoral strength and bone mineral density for predicting future hip and major osteoporotic fractures: a 16-year follow-up of the AGES-Reykjavik cohort","volume":"36","author":"Praveen","year":"2025","journal-title":"Osteoporos Int."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1002\/jbmr.3433","article-title":"Volumetric bone mineral density and failure load of distal limbs predict incident clinical fracture independent of FRAX and clinical risk factors among older men","volume":"33","author":"Langsetmo","year":"2018","journal-title":"J Bone Miner Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S2213-8587(18)30308-5","article-title":"Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the bone microarchitecture international consortium (BoMIC): a prospective study","volume":"7","author":"Samelson","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1093\/gerona\/gln035","article-title":"Risk factors for hip fracture in older home care clients","volume":"64","author":"Stolee","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.clnu.2024.03.032","article-title":"Geriatric nutritional risk index as a predictor for fragility fracture risk in elderly with type 2 diabetes mellitus: a 9-year ambispective longitudinal cohort study","volume":"43","author":"Pan","year":"2024","journal-title":"Clin Nutr."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/jcsm.13508","article-title":"The role of different physical function tests for the prediction of fracture risk in older women","volume":"15","author":"Gregori","year":"2024","journal-title":"J Cachexia Sarcopenia Muscle."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1002\/jbmr.4048","article-title":"The effect of fall biomechanics on risk for hip fracture in older adults: a cohort study of video-captured falls in long-term care","volume":"35","author":"Yang","year":"2020","journal-title":"J Bone Miner Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1177\/02692155241307504","article-title":"Relationship between postoperative dietary intake and walking ability among older adults with hip fractures: a retrospective study","volume":"39","author":"Kobayashi","year":"2025","journal-title":"Clin Rehabil."},{"key":"B23","doi-asserted-by":"publisher","first-page":"105321","DOI":"10.1016\/j.jamda.2024.105321","article-title":"Efficacy of fragility fracture integrated rehabilitation management in older adults with hip fractures: a randomized controlled trial with 1-year follow-up","volume":"26","author":"Lim","year":"2025","journal-title":"J Am Med Dir Assoc."},{"key":"B24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/ejendo\/lvae080","article-title":"Predicting fragility fractures based on frailty and bone mineral density among rural community-dwelling older adults","volume":"191","author":"Lee","year":"2024","journal-title":"Eur J Endocrinol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00198-023-06950-0","article-title":"Performance of FRAX in older adults with frailty: the Framingham Heart Study","volume":"35","author":"Chattaris","year":"2024","journal-title":"Osteoporos Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"glae186","DOI":"10.1093\/gerona\/glae186","article-title":"Frailty status, sedentary behaviors, and risk of incident bone fractures","volume":"79","author":"Zhou","year":"2024","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"101047","DOI":"10.1016\/j.arr.2020.101047","article-title":"multidimensional approach to frailty in older people","volume":"60","author":"Pilotto","year":"2020","journal-title":"Ageing Res Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1159\/000528561","article-title":"Frailty: pathophysiology, theoretical and operational definition(s), impact, prevalence, management and prevention, in an increasingly economically developed and ageing world","volume":"69","author":"Doody","year":"2023","journal-title":"Gerontology."},{"key":"B29","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s12603-023-1935-8","article-title":"Frailty is a risk factor for falls in the older adults: a systematic review and meta-analysis","volume":"27","author":"Yang","year":"2023","journal-title":"J Nutr Health Aging."},{"key":"B30","doi-asserted-by":"publisher","first-page":"117662","DOI":"10.1016\/j.bone.2025.117662","article-title":"Association of frailty with incident fractures and the mediating effect of inflammatory biomarkers: a prospective cohort study from the UK biobank","volume":"201","author":"Zhang","year":"2025","journal-title":"Bone."},{"key":"B31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12877-025-05716-z","article-title":"Association between frailty, as measured by the FRAIL scale, and 1-year mortality in older patients undergoing hip fracture surgery","volume":"25","author":"Xi","year":"2025","journal-title":"BMC Geriatr."},{"key":"B32","doi-asserted-by":"publisher","first-page":"105264","DOI":"10.1016\/j.archger.2023.105264","article-title":"The role of frailty risk for fracture-related hospital readmission and mortality after a hip fracture","volume":"117","author":"Mitsutake","year":"2024","journal-title":"Arch Gerontol Geriatr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1152\/physrev.00037.2021","article-title":"A multisystem physiological perspective of human frailty and its modulation by physical activity","volume":"103","author":"Taylor","year":"2023","journal-title":"Physiol Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1093\/gerona\/glv202","article-title":"Physical resilience in older adults: systematic review and development of an emerging construct","volume":"71","author":"Whitson","year":"2016","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3389\/fnhum.2016.00613","article-title":"Elderly fallers enhance dynamic stability through anticipatory postural adjustments during a choice stepping reaction time","volume":"10","author":"Tisserand","year":"2016","journal-title":"Front Hum Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1186\/s12877-022-03416-6","article-title":"Sensory and motor correlates of frailty: dissociation between frailty phenotype and frailty index","volume":"22","author":"Beier","year":"2022","journal-title":"BMC Geriatr."},{"key":"B38","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2147\/CIA.S168687","article-title":"Current and emerging biomarkers of frailty in the elderly","volume":"14","author":"Saedi","year":"2019","journal-title":"CIA."},{"key":"B39","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.3346\/jkms.2020.35.e16","article-title":"Frailty and comprehensive geriatric assessment","volume":"35","author":"Lee","year":"2019","journal-title":"J Korean Med Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"100784","DOI":"10.1016\/j.clinsp.2025.100784","article-title":"The impact of muscle mass, strength, and physical functioning on postural balance in older adults with sarcopenia","volume":"80","author":"Wang","year":"2025","journal-title":"Clinics."},{"key":"B42","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s40520-025-02997-7","article-title":"Sarcopenia-related traits and risk of falls in older adults: results from meta-analysis of cohort studies and Mendelian randomization analyses","volume":"37","author":"Yang","year":"2025","journal-title":"Aging Clin Exp Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/jbmr.4619","article-title":"Muscle strength and physical performance are associated with risk of postfracture mortality but not subsequent fracture in men","volume":"37","author":"Alajlouni","year":"2022","journal-title":"J Bone Miner Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"105385","DOI":"10.1016\/j.archger.2024.105385","article-title":"Association between handgrip strength weakness and asymmetry with incident hip fracture among older Chinese adults","volume":"122","author":"Zhou","year":"2024","journal-title":"Arch Gerontol Geriatr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1002\/jbmr.4884","article-title":"Association between sarcopenia and fracture risk in a population from the UK biobank database","volume":"38","author":"Jauffret","year":"2023","journal-title":"J Bone Miner Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1093\/jbmr\/zjae026","article-title":"Sarcopenia definitions and their association with fracture risk in older Swedish women","volume":"39","author":"Gandham","year":"2024","journal-title":"J Bone Miner Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/j.jamda.2020.09.038","article-title":"The short physical performance battery (SPPB): a quick and useful tool for fall risk stratification among older primary care patients","volume":"22","author":"Welch","year":"2021","journal-title":"J Am Med Dir Assoc."},{"key":"B48","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.jamda.2018.12.005","article-title":"Physical performance predictor measures in older adults with falls-related emergency department visits","volume":"20","author":"Pua","year":"2019","journal-title":"J Am Med Dir Assoc."},{"key":"B49","doi-asserted-by":"publisher","first-page":"afac273","DOI":"10.1093\/ageing\/afac273","article-title":"Protective responses of older adults for avoiding injury during falls: evidence from video capture of real-life falls in long-term care","volume":"51","author":"Robinovitch","year":"2022","journal-title":"Age Ageing"},{"key":"B50","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jbiomech.2015.02.025","article-title":"Kinematic analysis of video-captured falls experienced by older adults in long-term care","volume":"48","author":"Choi","year":"2015","journal-title":"J Biomech."},{"key":"B51","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s43465-023-01022-1","article-title":"Sarcopenia and osteoporosis","volume":"57","author":"Das","year":"2023","journal-title":"Indian J Orthop."},{"key":"B52","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/jcsm.12198","article-title":"Associations of muscle force, power, cross-sectional muscle area and bone geometry in older UK men","volume":"8","author":"Zengin","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle."},{"key":"B53","doi-asserted-by":"publisher","first-page":"62","DOI":"10.22540\/JFSF-02-062","article-title":"Mechanical loading effect to the functional bone adaptation","volume":"2","author":"Kokkinias","year":"2017","journal-title":"J Frailty Sarcopenia Falls."},{"key":"B54","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bone.2015.04.014","article-title":"Bone and skeletal muscle: key players in mechanotransduction and potential overlapping mechanisms","volume":"80","author":"Goodman","year":"2015","journal-title":"Bone."},{"key":"B55","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1210\/endrev\/bnaa016","article-title":"Muscle-organ crosstalk: the emerging roles of myokines","volume":"41","author":"Severinsen","year":"2020","journal-title":"Endocr Rev."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.3390\/cells12162088","article-title":"Crosstalk between bone and muscles during physical activity","volume":"12","author":"Dalle Carbonare","year":"2023","journal-title":"Cells."},{"key":"B57","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/bonekey.2016.48","article-title":"Effects of myokines on bone","volume":"5","author":"Kaji","year":"2016","journal-title":"Bonekey Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr Osteoporos Rep."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1007\/s00198-017-3929-z","article-title":"The association between sarcopenia and functional outcomes among older patients with hip fracture undergoing in-hospital rehabilitation","volume":"28","author":"Landi","year":"2017","journal-title":"Osteoporos Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e91105","DOI":"10.7759\/cureus.91105","article-title":"Sarcopenia as an independent predictor of poorer functional outcomes in patients undergoing post-hip fracture rehabilitation","volume":"17","author":"Sawamura","year":"2025","journal-title":"Cureus."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1007\/s12603-019-1289-4","article-title":"Functional outcomes of fragility fracture integrated rehabilitation management in sarcopenic patients after hip fracture surgery and predictors of independent ambulation","volume":"23","author":"Lim","year":"2019","journal-title":"J Nutrit Health Aging."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment","author":"Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2023.09.027","article-title":"Associations between osteosarcopenia and falls, fractures, and frailty in older adults: results from the Canadian longitudinal study on aging (CLSA)","author":"Lee","year":"2024","journal-title":"J Am Med Dir Assoc"},{"key":"B64","doi-asserted-by":"publisher","first-page":"253","DOI":"10.12968\/hmed.2018.79.5.253","article-title":"Osteosarcopenia","volume":"79","author":"Paintin","year":"2018","journal-title":"Br J Hosp Med (Lond)."},{"key":"B65","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/rheumatology\/keaa755","article-title":"Osteosarcopenia: where osteoporosis and sarcopenia collide","volume":"60","author":"Clynes","year":"2021","journal-title":"Rheumatology (Oxford)."},{"key":"B66","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/gerona\/glt097","article-title":"Physical behavior and function early after hip fracture surgery in patients receiving comprehensive geriatric care or orthopedic care\u2014a randomized controlled trial","author":"Taraldsen","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3238\/arztebl.2020.0053","article-title":"The association between orthogeriatric co-management and mortality following hip fracture","volume":"117","author":"Rapp","year":"2020","journal-title":"Dtsch Arztebl Int."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/S0140-6736(14)62409-0","article-title":"Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial","volume":"385","author":"Prestmo","year":"2015","journal-title":"Lancet."},{"key":"B69","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.lanwpc.2021.100348","article-title":"The effectiveness of a co-management care model on older hip fracture patients in China\u2014A multicentre non-randomised controlled study","volume":"19","author":"Zhang","year":"2022","journal-title":"Lancet Regi Health\u2014Western Pacific"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5704\/MOJ.2307.001","article-title":"Fracture liaison service and its role in secondary fracture prevention in Malaysia: a scoping review","volume":"17","author":"Lim","year":"2023","journal-title":"Malays Orthop J."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1007\/s00198-024-07181-7","article-title":"Fracture liaison service\u2014a multidisciplinary approach to osteoporosis management","volume":"35","author":"Le","year":"2024","journal-title":"Osteoporos Int."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s00198-021-05911-9","article-title":"The impact of fracture liaison services on subsequent fractures and mortality: a systematic literature review and meta-analysis","volume":"32","author":"Li","year":"2021","journal-title":"Osteoporos Int."},{"key":"B73","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.bone.2018.03.018","article-title":"Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: a systematic literature review and meta-analysis","volume":"111","author":"Wu","year":"2018","journal-title":"Bone."},{"key":"B74","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11657-020-00736-1","article-title":"Implementation of a fracture liaison service and its effects on osteoporosis treatment adherence and secondary fracture at a tertiary care academic health system","volume":"15","author":"Scholten","year":"2020","journal-title":"Arch Osteoporos."},{"key":"B75","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00198-024-07325-9","article-title":"The impact of a fracture liaison service with in-hospital anti-osteoporosis treatment on subsequent hip fracture and mortality rates\u2014a single-center retrospective study","volume":"36","author":"Yoel","year":"2025","journal-title":"Osteoporos Int."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1881899\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:49:50Z","timestamp":1785905390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1881899\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":75,"alternative-id":["10.3389\/fmed.2026.1881899"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1881899","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"article-number":"1881899"}}