{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:18:43Z","timestamp":1783491523258,"version":"3.55.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    This case report describes the efficacy of omadacycline for the treatment of Japanese spotted fever. A 57-years-old woman presented with fever and maculopapular rash, followed by dyspnea. Laboratory abnormalities included respiratory failure, thrombocytopenia, liver dysfunction, and elevated inflammatory markers.\n                    <jats:italic>Rickettsia japonica<\/jats:italic>\n                    , the causative pathogen, was detected in bronchoalveolar lavage fluid (BALF). Based on the clinical manifestations, laboratory findings, and microbiological evidence, a diagnosis of Japanese spotted fever caused by\n                    <jats:italic>Rickettsia japonica<\/jats:italic>\n                    was considered. She received anti-infective therapy, intravenous polyene phosphatidylcholine, human albumin and platelet transfusions, along with symptomatic supportive care. After 14 days of omadacycline treatment, inflammatory markers and platelet counts normalized, and chest CT showed significant improvement, leading to full recovery and discharge. This case indicates that omadacycline may have contributed to the patient\u2019s recovery, alongside multiple concurrent treatments.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1882022","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:57:04Z","timestamp":1783490224000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Effective use of omadacycline in Japanese spotted fever"],"prefix":"10.3389","volume":"13","author":[{"given":"Xue","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]},{"name":"Key Laboratory of Respiratory Inflammatory Injury and Precision Diagnosis and Treatment, Chongqing Municipal Health and Health Committee","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ling","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]},{"name":"Key Laboratory of Respiratory Inflammatory Injury and Precision Diagnosis and Treatment, Chongqing Municipal Health and Health Committee","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1099\/00207713-42-2-303","article-title":"Rickettsia japonica sp. 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fever.","volume":"99","author":"Noguchi","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.2147\/IDR.S253540","article-title":"Clinical features, laboratory characteristics and prognostic factors of severity in patients with rickettsiaceae at two military hospitals, Northern Vietnam.","volume":"13","author":"Le Van","year":"2020","journal-title":"Infect Drug Resist"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1128\/AAC.01242-13","article-title":"In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline.","volume":"58","author":"Macone","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e0066521","DOI":"10.1128\/AAC.00665-21","article-title":"In vitro susceptibility of rickettsia species to eravacycline, omadacycline, and tigecycline.","volume":"65","author":"Quade","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"B15","doi-asserted-by":"publisher","first-page":"102707","DOI":"10.1016\/j.tmaid.2024.102707","article-title":"Application of omadacycline in the treatment of severe Japanese spotted fever.","volume":"58","author":"Xu","year":"2024","journal-title":"Travel Med Infect Dis"}],"container-title":["Frontiers in 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