{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:00:00Z","timestamp":1785387600345,"version":"3.55.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"\n Objective<\/jats:title>\n To characterize the clinical and immunological features of rheumatoid arthritis (RA) patients with positive anti-centromere antibody (ACA).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this retrospective case-control study, the clinical manifestations, demographic data, and immunological test results of these patients were collected and analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n ACA-positive RA patients exhibited a significantly higher prevalence of Raynaud\u2019s phenomenon (15.0% vs. 2.5%,\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n = 4.838,\n P<\/jats:italic>\n = 0.028), xerostomia (22.5% vs. 8.8%,\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n = 4.363,\n P<\/jats:italic>\n = 0.037), xerophthalmia (27.5% vs. 10.0%,\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n = 6.128,\n P<\/jats:italic>\n = 0.013), and interstitial pneumonia (27.5% vs. 5.0%,\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n = 12.343,\n P<\/jats:italic>\n &lt; 0.001), as well as higher rates of elevated ALP (18.9% vs. 1.3%,\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n = 9.780,\n P<\/jats:italic>\n = 0.002) and GGT (33.33% vs. 15.0%,\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n = 5.086,\n P<\/jats:italic>\n = 0.024).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n ACA-positive RA may present a unique phenotype characterized by an increased risk of interstitial lung disease, sicca symptoms, and cholestatic liver injury; thus, enhanced pulmonary\/hepatic screening and tailored monitoring strategies are critical.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmed.2026.1882422","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:22:20Z","timestamp":1785385340000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and immunological features of rheumatoid arthritis patients with positive anti-centromere antibody: a case-control study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiuqing","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]},{"name":"Department of Rheumatology and Clinical Immunology, Shandong Medical and Pharmaceutical University Hospital, Binzhou","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]},{"name":"Department of Rheumatology and Clinical Immunology, Ji\u2019an Central People\u2019s Hospital, Ji\u2019an","place":["Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Shandong Medical and Pharmaceutical University Hospital, Binzhou","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Shandong Medical and Pharmaceutical University Hospital, Binzhou","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis.","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1073\/pnas.77.3.1627","article-title":"Autoantibody to centromere (kinetochore) in scleroderma sera.","volume":"77","author":"Moroi","year":"1980","journal-title":"Proc Natl Acad Sci USA."},{"key":"B3","first-page":"277","article-title":"Anticentromere 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