{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:00:06Z","timestamp":1785214806829,"version":"3.55.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate risk stratification of pigmented skin lesions is essential for early melanoma detection and for reducing unnecessary excisions. Although artificial intelligence (AI) is increasingly applied to dermoscopic image analysis, its diagnostic performance compared to dermoscopy remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare the diagnostic performance of AI, dermoscopy, and AI-assisted clinicians for malignancy risk stratification of pigmented skin lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, Web of Science, and the Cochrane Library were systematically searched for studies evaluating AI, dermoscopy, or AI-assisted clinicians in diagnosing pigmented or melanoma-suspected skin lesions. Diagnostic performance metrics were calculated from extracted or reconstructed data, and study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool (QUADAS-2) and QUADAS-comparative (QUADAS-C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2,571 records were identified, and 10 studies were included in the primary quantitative analysis, contributing 17 diagnostic arms. These included 10 dermoscopy arms, 6 AI-alone arms, and 1 AI-assisted clinician arm. In the dermoscopy group, sensitivity ranged from 0.418 to 0.966, and specificity ranged from 0.293 to 0.975. In the AI group, sensitivity ranged from 0.164 to 0.968, and specificity ranged from 0.374 to 0.983. AI-assisted clinicians showed a sensitivity of 1.000 and a specificity of 0.837 in the single available study. Overall, AI and dermoscopy showed overlapping diagnostic performance, although substantial variability was observed across AI algorithms and clinical settings. Deeks\u2019 funnel plots showed no evidence of significant publication bias in either the AI group or the dermoscopy group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Autonomous AI showed diagnostic performance broadly comparable to dermoscopy. Although AI achieved slightly higher pooled specificity, its sensitivity was lower, indicating no clear clinical advantage over conventional dermoscopic assessment. Evidence on AI-assisted clinicians was limited to a single diagnostic arm; therefore, this finding should be interpreted as hypothesis-generating rather than as evidence to support immediate clinical implementation. Further comparative studies using standardized AI-assisted workflows, comparable physician expertise, and patient-centered outcomes are required before practical recommendations can be made.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>Registered with PROSPERO (CRD420261389834).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1883944","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:26:48Z","timestamp":1785212808000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Artificial intelligence vs. dermoscopy for malignancy risk stratification of pigmented skin lesions: a systematic review and meta-analysis for public health"],"prefix":"10.3389","volume":"13","author":[{"given":"Ming","family":"Diao","sequence":"first","affiliation":[{"name":"Pengzhou People's Hospital","place":["Pengzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Pengzhou People's Hospital","place":["Pengzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Tang","sequence":"additional","affiliation":[{"name":"Pengzhou People's Hospital","place":["Pengzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e260217","DOI":"10.1001\/jamadermatol.2026.0217","article-title":"Prospective evidence on artificial intelligence-assisted melanoma diagnostics: a systematic review and meta-analysis","volume":"162","author":"Laiouar-Pedari","year":"2026","journal-title":"JAMA Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/s0140-6736(18)31559-9","article-title":"Melanoma","volume":"392","author":"Schadendorf","year":"2018","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1001\/jamadermatol.2016.0624","article-title":"Validity and reliability of dermoscopic criteria used to differentiate nevi from melanoma: a web-based international Dermoscopy society study","volume":"152","author":"Carrera","year":"2016","journal-title":"JAMA Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/bjd.15339","article-title":"Update on dermoscopy of spitz\/reed naevi and management guidelines by the international Dermoscopy society","volume":"177","author":"Lallas","year":"2017","journal-title":"Br J Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/j.1365-2133.2008.08713.x","article-title":"Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting","volume":"159","author":"Vestergaard","year":"2008","journal-title":"Br J Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S1470-2045(02)00679-4","article-title":"Diagnostic accuracy of dermoscopy","volume":"3","author":"Kittler","year":"2002","journal-title":"Lancet Oncol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1001\/archderm.137.10.1343","article-title":"Is dermoscopy (epiluminescence microscopy) an additional tool for diagnosing melanoma? 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