{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:33:40Z","timestamp":1786556020096,"version":"build-2736575974"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Lady finger banana peel (\n                      <jats:italic>Musa acuminata<\/jats:italic>\n                      Colla) contains several phytochemical compounds with antioxidant activity that may be relevant to skin aging. However, clinical evidence regarding its use as a nanoparticle-based topical formulation remains limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate within-participant changes in facial photoaging manifestations and serum matrix metalloproteinase-1 (MMP-1) levels following 12\u202fweeks of topical application of a 5% lady finger banana peel extract nanoparticle serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, single-center, single-arm, uncontrolled pretest\u2013posttest proof-of-concept study enrolled women aged 25\u201350\u202fyears with clinical signs of facial skin aging. Participants applied 10 drops, approximately 0.5\u202fmL, of the study serum once nightly for 12\u202fweeks. Serum MMP-1 levels were measured using enzyme-linked immunosorbent assay at baseline and week 12. Dermoscopy Photoaging Scale (DPAS) scores were evaluated at baseline and weeks 4, 8, and 12. Changes in serum MMP-1 levels and DPAS scores were analyzed using the Wilcoxon signed-rank test and Friedman test, respectively. Adherence and adverse events were evaluated throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty participants were enrolled, of whom one discontinued the study because of non-adherence. A total of 49 participants completed the study and were included in the analysis. Mean serum MMP-1 levels decreased from 0.48\u202f\u00b1\u202f0.39\u202fng\/mL at baseline to 0.26\u202f\u00b1\u202f0.25\u202fng\/mL at week 12 (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Mean DPAS scores decreased from 12.69\u202f\u00b1\u202f0.92 at baseline to 9.51\u202f\u00b1\u202f0.77 at week 12 (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Changes in DPAS scores were modestly correlated with changes in serum MMP-1 levels (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f0.347;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.015). No adverse events were observed or reported among participants who completed the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower DPAS scores and serum MMP-1 levels were observed following 12\u202fweeks of topical serum use. Because this was an uncontrolled single-arm study, the findings should be regarded as preliminary and do not establish treatment efficacy, causality, systemic absorption, or modulation of cutaneous MMP-1. Randomized vehicle-controlled studies incorporating local skin biomarkers are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1886006","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:40:11Z","timestamp":1786552811000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in dermoscopic photoaging and serum MMP-1 following 12\u202fweeks of 5% lady finger banana peel extract nanoparticle serum: a single-arm proof-of-concept study"],"prefix":"10.3389","volume":"13","author":[{"given":"Khairina","family":"Nasution","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]},{"name":"Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelva Karmila","family":"Jusuf","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]},{"name":"Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imam Budi","family":"Putra","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]},{"name":"Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliandi","family":"Harahap","sequence":"additional","affiliation":[{"name":"Department of Community Medicine\/Public Health, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairuddin","family":"Djawad","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Universitas Hasanuddin","place":["Makassar, South Sulawesi, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibnu","family":"Alferraly","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Mahmud","family":"Amin","sequence":"additional","affiliation":[{"name":"Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]},{"name":"Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairani","family":"Sukatendel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Sumatera Utara","place":["Medan, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref1","first-page":"130","volume-title":"Textbook of Aging Skin","author":"Assaf","year":"2010"},{"key":"ref2","first-page":"25","article-title":"Formulasi dan uji stabilitas fisik serum spray ekstrak umbi wortel (Daucus carota L.) sebagai anti aging","volume":"6","author":"Ermawati","year":"2022","journal-title":"Jurnal Kesehatan Yamasi Makassar"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"308","DOI":"10.4161\/derm.22804","article-title":"Skin anti-aging 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