{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:52:20Z","timestamp":1785912740984,"version":"3.56.0"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This case report presents a 31-year-old male patient with lipemia retinalis secondary to a pituitary neuroendocrine tumor (PitNET). The patient presented with a 3-year history of progressive facial changes and enlargement of the hands and feet. Physical examination revealed typical signs of acromegaly. Cranial magnetic resonance imaging (MRI) confirmed a pituitary tumor. Laboratory examinations revealed significant elevations in growth hormone, insulin-like growth factor-1 (IGF-1), and serum lipid levels, along with chylous blood. Bilateral fundus examination showed characteristic creamy-pink discoloration of retinal arteries and veins, as well as a darkened retina with slight salmon-pink discoloration. After treatment with lipid-lowering therapy, glycemic control, and pituitary tumor resection, the patient\u2019s serum lipid levels, blood glucose, and growth hormone levels returned to normal, and the fundus manifestations resolved completely. Lipemia retinalis is an uncommon ocular disorder, and its occurrence secondary to a pituitary tumor is extremely rare. Clinicians are advised to closely monitor lipid metabolism and ocular manifestations in patients with pituitary tumors. Early identification of lipemia retinalis can help prevent serious adverse outcomes such as retinal vascular occlusion and systemic vascular complications.<\/jats:p>","DOI":"10.3389\/fmed.2026.1888102","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:29:32Z","timestamp":1785911372000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lipemia retinalis secondary to pituitary neuroendocrine tumor: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Tingting","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/eye.1996.138","article-title":"Lipaemia retinalis: a question of chylomicrons?","volume":"10","author":"Rayner","year":"1996","journal-title":"Eye (Lond)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.jaapos.2018.03.014","article-title":"Lipemia retinalis as the presenting sign of undiagnosed type 1 diabetes mellitus resulting in severe secondary hypertriglyceridemia","volume":"22","author":"Trese","year":"2018","journal-title":"J AAPOS"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1016\/j.jcjo.2022.02.019","article-title":"Lipemia retinalis after alcohol abuse","volume":"57","author":"Moreno Guti\u00e9rrez","year":"2022","journal-title":"Can J Ophthalmol"},{"key":"ref4","first-page":"83","article-title":"Lipemia retinalis due to secondary hyperlipidemia in type 1 diabetes mellitus","volume":"64","author":"Gayathri","year":"2016","journal-title":"J Assoc Physicians India"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e643","DOI":"10.1111\/aos.13525","article-title":"Ultrawide field scanning laser ophthalmoscopy imaging of lipemia retinalis","volume":"96","author":"Silva","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/s0002-9394(02)02076-7","article-title":"Lipemia retinalis associated with branch retinal vein occlusion","volume":"135","author":"Nagra","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1056\/NEJMicm065167","article-title":"Images in clinical medicine. 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