{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:21:05Z","timestamp":1787851265150,"version":"build-2784847793"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Intranodal palisaded myofibroblastoma (IPM) is a rare benign mesenchymal tumor of lymph nodes that most often arises in the inguinal region. We report an 18-year-old woman with an incidentally detected left supraclavicular mass. Imaging showed a well-circumscribed hypervascular lesion, and core biopsy demonstrated a spindle-cell neoplasm for which low-grade malignancy could not be excluded. Complete excision revealed an intranodal spindle-cell proliferation with nuclear palisading, hemorrhage, compressed peripheral lymphoid tissue, and hyalinized fibers. The morphology and immunophenotype supported IPM. Targeted sequencing identified an HDAC2 p.V12Sfs\n                    <jats:sup>*<\/jats:sup>\n                    8 variant, whereas no CTNNB1 variant was detected. Because no functional validation was performed, the biological significance of the HDAC2 variant remains uncertain. This case highlights IPM in an adolescent at an uncommon supraclavicular site and emphasizes careful pathological evaluation of spindle-cell lymph-node lesions.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1889299","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:29:35Z","timestamp":1787848175000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intranodal palisaded myofibroblastoma of the supraclavicular region in an adolescent with an HDAC2 variant: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Yiyang","family":"Yu","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang","place":["Shandong, China"]},{"name":"Department of Oncology, Zibo Central Hospital, Zibo","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang","place":["Shandong, China"]},{"name":"Department of Oncology, Zibo Central Hospital, Zibo","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Zibo Central Hospital, Zibo","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.revmed.2023.10.439","article-title":"Intranodal palisaded myofibroblastome: a rare cause of inguinal lymphadenopathy","volume":"45","author":"Gomes de Pinho","year":"2024","journal-title":"Rev Med Internet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1362090","DOI":"10.3389\/fonc.2024.1362090","article-title":"Intranodal palisaded myofibroblastoma in the submandibular gland region: a case report","volume":"14","author":"Zhang","year":"2024","journal-title":"Front Oncol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1007\/s12070-023-03771-9","article-title":"Parotid's intranodal palisaded myofibroblastoma: a very rare tumour","volume":"75","author":"Rizkou","year":"2023","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/dc.24303","article-title":"Intranodal palisaded myofibroblastoma of para-esophageal lymph node: case report with cytologic and histologic findings","volume":"47","author":"Hu","year":"2019","journal-title":"Diagn Cytopathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/tbj.13447","article-title":"Intranodal palisaded myofibroblastoma of the axilla","volume":"25","author":"P\u00e9rez-Serrano","year":"2019","journal-title":"Breast J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1016\/j.athoracsur.2015.11.060","article-title":"Intranodal palisaded myofibroblastoma masquerading as N2 non-small cell lung carcinoma","volume":"102","author":"Yim","year":"2016","journal-title":"Ann Thorac Surg Short Rep."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-11-7","article-title":"Intranodal palisaded myofibroblastoma originating from retroperitoneum: an unusual origin","author":"Sagar","year":"2011","journal-title":"BMC Clin Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e934752","DOI":"10.12659\/AJCR.934752","article-title":"Intranodal palisaded myofibroblastoma: a diagnostic differential for inguinal lymphadenopathy","volume":"22","author":"Haddad","year":"2021","journal-title":"Am J Case Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"100791","DOI":"10.1016\/j.patol.2024.100791","article-title":"Axillary intranodal palisaded myofibroblastoma, a rare tumour at an unusual site, with literature review","volume":"58","author":"Aden","year":"2025","journal-title":"Rev Esp Patol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1111\/apm.12580","article-title":"Intranodal palisaded myofibroblastoma \u2013 a rare case report and literature review","volume":"124","author":"Karabulut","year":"2016","journal-title":"APMIS."},{"key":"B11","doi-asserted-by":"publisher","first-page":"306","DOI":"10.5858\/2007-131-306-IPM","article-title":"Intranodal palisaded myofibroblastoma","volume":"131","author":"Nguyen","year":"2007","journal-title":"Arch Pathol Lab Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/00000478-198905000-00001","article-title":"Palisaded myofibroblastoma. 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