{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:05:55Z","timestamp":1784696755354,"version":"3.55.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease initiated by injury to hepatic sinusoidal endothelial cells. Its main clinical manifestations include hepatomegaly, elevated bilirubin, ascites and weight gain. The incidence of HSOS has been increasing year by year. Nevertheless, due to its non-specific clinical manifestations, limited effective diagnostic methods and imperfect relevant diagnostic criteria, it is highly likely to be misdiagnosed as other liver diseases. This study reports a case of HSOS induced by ingestion of\n                    <jats:italic>Gynura segetum<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1889644","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:39:43Z","timestamp":1784695183000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Hepatic sinusoidal obstruction syndrome caused by Gynura segetum"],"prefix":"10.3389","volume":"13","author":[{"given":"Bochen","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Yichang Central People\u2019s Hospital, The First College of Clinical Medical Science, China Three Gorges University","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Yichang Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangcheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Yichang Central People\u2019s Hospital, The First College of Clinical Medical Science, China Three Gorges University","place":["Yichang, China"]},{"name":"Department of Infectious Diseases, Yichang Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Yichang Central People\u2019s Hospital, The First College of Clinical Medical Science, China Three Gorges University","place":["Yichang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1053\/j.gastro.2019.02.002","article-title":"Incidence and Etiology of drug-induced liver injury in mainland China","volume":"156","author":"Shen","year":"2019","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1111\/jgh.14612","article-title":"Expert consensus on the clinical management of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome","volume":"34","author":"Zhuge","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.3748\/wjg.v25.i28.3753","article-title":"Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes","volume":"25","author":"Yang","year":"2019","journal-title":"World J Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12876-020-1180-0","article-title":"Clinical characteristics, CT signs, and pathological findings of pyrrolizidine alkaloids-induced sinusoidal obstructive syndrome: a retrospective study","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.21037\/atm-20-731","article-title":"Prognostic factors for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome: a multicenter study in China","volume":"9","author":"Shang","year":"2021","journal-title":"Ann Transl Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.clinre.2020.03.019","article-title":"Sinusoidal obstruction syndrome","volume":"44","author":"de L\u00e9dinghen","year":"2020","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3390\/molecules31030410","article-title":"Hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids from Gynura segetum: mechanisms and therapeutic advances","volume":"31","author":"Zhou","year":"2026","journal-title":"Molecules"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"152882","DOI":"10.1016\/j.tox.2021.152882","article-title":"Oxaliplatin-induced hepatic sinusoidal obstruction syndrome","volume":"460","author":"Zhu","year":"2021","journal-title":"Toxicology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/1751-2980.12112","article-title":"Tusanqi and hepatic sinusoidal obstruction syndrome","volume":"15","author":"Wang","year":"2014","journal-title":"J Dig Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"9241","DOI":"10.12998\/wjcc.v10.i26.9241","article-title":"Early diagnostic value of liver stiffness measurement in hepatic sinusoidal obstruction syndrome induced by hematopoietic stem cell transplantation","volume":"10","author":"Tan","year":"2022","journal-title":"World J Clin Cases"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5620","DOI":"10.3390\/ijms24065620","article-title":"Molecular advances in sinusoidal obstruction syndrome\/Veno-occlusive disease","volume":"24","author":"Mavrikou","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/s41409-023-01992-8","article-title":"Diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)","volume":"58","author":"Mohty","year":"2023","journal-title":"Bone Marrow Transplant"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/s41409-025-02598-y","article-title":"Management of liver sinusoidal obstruction syndrome\/veno-occlusive disease in adults: a 2025 perspective from an international expert group","volume":"60","author":"Larue","year":"2025","journal-title":"Bone Marrow Transplant"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s00204-024-03950-9","article-title":"Drug-induced hepatic sinusoidal obstruction syndrome: current advances and future perspectives","volume":"99","author":"Yu","year":"2025","journal-title":"Arch Toxicol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"345","DOI":"10.14218\/JCTH.2020.00124","article-title":"Validation of the Nanjing criteria for diagnosing pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome","volume":"9","author":"Zhang","year":"2021","journal-title":"J Clin Transl Hepatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1625825","DOI":"10.3389\/fmed.2025.1625825","article-title":"Efficacy and safety of transjugular intrahepatic portosystemic shunt in hepatic sinusoidal obstruction syndrome: systematic review and meta-analysis","volume":"12","author":"Jiang","year":"2025","journal-title":"Front Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1097\/00007890-198712000-00011","article-title":"Venoocclusive disease of the liver following bone marrow transplantation","volume":"44","author":"Jones","year":"1987","journal-title":"Transplantation"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.7326\/0003-4819-118-4-199302150-00003","article-title":"Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients","volume":"118","author":"McDonald","year":"1993","journal-title":"Ann Intern Med"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1889644\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:40:07Z","timestamp":1784695207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1889644\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":18,"alternative-id":["10.3389\/fmed.2026.1889644"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1889644","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"article-number":"1889644"}}