{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:18:43Z","timestamp":1788153523455,"version":"build-2803163510"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the long-term anatomical and functional outcomes of early posterior scleral contraction (PSC) in patients up to 30 years with myopic macular retinoschisis (MRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 21 patients (27 myopic eyes) with MRS, with or without macular detachment, who underwent PSC and had a postoperative follow-up exceeding 2 years (\n                      <jats:italic>n<\/jats:italic>\n                      = 27). Eyes with MRS underwent PSC, an extraocular procedure involving the placement of a genipin-crosslinked allogeneic strip at the posterior pole to shorten axial length and relieve vitreoretinal traction. Anatomical resolution of MRS, best-corrected visual acuity (BCVA), axial length change, were analyzed in patients with approximately 5-year follow-up records (the 13-eye main analysis cohort); while the overall safety profile was reported using the 27-eye descriptive cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At approximately postoperative year 5, complete resolution of MRS was achieved in 4 eyes (30.8%, 95% CI: 12.7%\u221257.6%), and partial resolution occurred in 9 eyes (69.2%, 95% CI: 42.4%\u221287.3%); BCVA did not improve significantly compared to the baseline level (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.482,\n                      <jats:italic>n<\/jats:italic>\n                      = 13). Mean axial length shortened significantly immediately postoperatively (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001,\n                      <jats:italic>n<\/jats:italic>\n                      = 13) but gradually regressed to near baseline at approximately postoperative year 5 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.183,\n                      <jats:italic>n<\/jats:italic>\n                      = 12). In the 27-eye descriptive cohort, no eye progressed to macular hole or retinal detachment, and metamorphopsia all resolved within 8 months. No sight-threatening intra- or postoperative complications, such as cataract, iatrogenic macular hole, were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early PSC may offer favorable anatomical stability and acceptable safety in young MRS patients. However, larger prospective controlled studies are needed to confirm its long-term efficacy and safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1892373","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:29:08Z","timestamp":1788150548000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term outcomes of early posterior scleral contraction for myopic macular retinoschisis in patients up to 30 years"],"prefix":"10.3389","volume":"13","author":[{"given":"Linyan","family":"Zheng","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University","place":["Wenzhou, 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Diseases, Eye Hospital, Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anquan","family":"Xue","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqian","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University","place":["Wenzhou, China"]},{"name":"National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou 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