{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:38:17Z","timestamp":1789486697978,"version":"build-2803163510"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Invasive pulmonary aspergillosis (IPA) presents life-threatening complication mostly seen in patients with severe neutropenia or in patients with solid organ cancers after applied anticancer therapy. The aim of this manuscript is to identify clinical manifestations of IPA in lung cancer patient. A 65-year-old male with a history of severe chronic obstructive lung disease and prior laryngeal carcinoma was admitted to hospital due to fever. Five months before he was operated because of early-stage squamous cell lung carcinoma. Postoperative course was complicated with subcutaneous emphysema and recurrent pneumothorax. The appearance of new excavated lesions in the contralateral lobes on repeated chest computed tomography (CT) raised concern for tumor recurrence. Subsequent bronchoscopy with bronchoaspirate culture yielded\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    . Molecular tests also showed positive findings for\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    presence. First-line treatment with voriconazole resulted in significant clinical and radiological improvement. Positron emission tomography (PET-CT) done 6\u202fmonths after voriconazole treatment showed only mild fluorodeoxyglucose (FDG) uptake in the right lower lobe, with no other areas of involvement This case highlights the importance of a multidisciplinary approach in lung cancer patients, where post-operative radiologic changes can represent tumor recurrence, bacterial infection or fungal disease.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1894021","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:13:11Z","timestamp":1789477991000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare clinical presentation of invasive pulmonary aspergillosis in patient with early-stage lung cancer: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Tatjana","family":"Adzi\u0107-Vukicevic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Belgrade","place":["Belgrade, Serbia"]},{"name":"Clinic for Pulmonology, University Clinical Center of Serbia","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sead","family":"Dalifi","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonology, University Clinical Center of Serbia","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Petkovic","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonology, University Clinical Center of Serbia","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Savic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade","place":["Belgrade, Serbia"]},{"name":"Clinic for Thoracic Surgery, University Clinical Center of Serbia","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Lukic","sequence":"additional","affiliation":[{"name":"Center for Radiology and MRI, University Clinical Center of Serbia","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Sobic-Saranovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade","place":["Belgrade, Serbia"]},{"name":"Center for Nuclear Medicine with PET, University Clinical Center of Serbia","place":["Belgrade, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Salmanton-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne","place":["Cologne, Germany"]},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne","place":["Cologne, Germany"]},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s12281-023-00461-5","article-title":"Aspergillosis: an update on clinical Spectrum, diagnostic schemes, and management","volume":"17","author":"Kanaujia","year":"2023","journal-title":"Curr Fungal Infect Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"003249","DOI":"10.12890\/2022_003249","article-title":"Concomitant pulmonary tuberculosis and invasive aspergillosis infection in an immunocompetent 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