{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:10:55Z","timestamp":1783923055056,"version":"3.55.0"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>A 25-year-old woman presented with a progressively enlarging abdominal mass and severe coagulopathy (fibrinogen 0.6 g\/L). Imaging revealed a giant, predominantly calcified hepatic lesion lacking typical nodular enhancement, raising suspicion for hamartoma or cystadenoma. Despite aggressive fibrinogen replacement, coagulopathy persisted. Multidisciplinary team discussion confirmed Kasabach-Merritt syndrome secondary to giant hepatic haemangioma. Anatomical left lateral sectionectomy was performed successfully. Histopathology confirmed cavernous haemangioma with thrombosis, infarction, and calcification. Coagulation parameters normalized immediately postoperatively. This case highlights the diagnostic pitfall of non-enhancing giant hepatic haemangioma and underscores the curative role of early surgical resection in adult Kasabach-Merritt syndrome.<\/jats:p>","DOI":"10.3389\/fmed.2026.1896193","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:34:49Z","timestamp":1783920889000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Surgical management of giant hepatic cavernous haemangioma with Kasabach\u2013Merritt syndrome in an adult"],"prefix":"10.3389","volume":"13","author":[{"given":"Liuyang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Biliary and Pancreatic, Xiangyang Central Hospital, School of Medicine, Wuhan University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqian","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2025.04.014","article-title":"Giant cavernous hemangioma of liver complicated by Kasabach-Merritt syndrome","author":"Xie","year":"2025","journal-title":"Dig Liver Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e747","DOI":"10.1016\/j.amjmed.2020.02.032","article-title":"Giant liver hemangioma with Kasabach-Merritt syndrome","volume":"133","author":"Albitar","year":"2020","journal-title":"Am J Med."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/his.15374","article-title":"Advances in vascular anomalies: refining classification in the molecular era","author":"Putra","year":"2024","journal-title":"Histopathology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015412","article-title":"Targeting inflammation-induced Kasabach-Merritt phenomenon","author":"Borst","year":"2022","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-020-00379-9","article-title":"Standards of care for Kasabach-Merritt phenomenon in China","author":"Yao","year":"2021","journal-title":"World J Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2196090","DOI":"10.1080\/07853890.2023.2196090","article-title":"Efficacy of TACE combined with sirolimus for Kasabach-Merritt phenomenon","volume":"55","author":"Yin CG Qi","year":"2023","journal-title":"Ann Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5582\/bst.2023.01152","article-title":"Surgical indications for solid hepatic benign tumors: an updated literature review","volume":"17","author":"Zhang","year":"2023","journal-title":"BioSci Trends."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1896193\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:34:52Z","timestamp":1783920892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1896193\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":7,"alternative-id":["10.3389\/fmed.2026.1896193"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1896193","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]},"article-number":"1896193"}}