{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:59:38Z","timestamp":1790657978988,"version":"4.1.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radial artery dimensions before and after intra-arterial vasodilator administration remain incompletely characterized along the vessel. This study used optical coherence tomography (OCT) to assess paired changes in mean lumen diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve patients underwent baseline OCT 5\u2005min after limited sheath insertion and post-administration OCT after intra-arterial nitroglycerin and verapamil, before coronary angiography. The full OCT-imaged radial artery span was divided into equal proximal, middle, and distal thirds before selecting anatomically matched analyzable portions. Analysis included 1,482 matched cross-sectional pairs (2,964 frames), with a cumulative matched analyzable length of 1,404.4\u2005mm. Measurements at matched 1-mm intervals were aggregated within patients. Mean lumen diameter was the representative lumen metric; area and volume were supportive measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean lumen diameter increased from 3.06\u2009\u00b1\u20090.49 to 3.35\u2009\u00b1\u20090.56\u2005mm (mean paired change, 0.29\u2005mm; 95% CI, 0.20\u20130.39;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). The mean patient-level relative increase was 9.6%. Mean increases were observed in all three thirds in exploratory analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mean radial artery lumen diameter was greater after intra-arterial nitroglycerin and verapamil than at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.chictr.org.cn\/hvshowproject.html?id=270,922&amp;amp;v=1.1<\/jats:ext-link>\n                      , Chinese Clinical Trial Registry (ChiCTR) ChiCTR2500097574.\n                    <\/jats:p>\n                  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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Luhe Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Luhe Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Beijing Luhe Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Luhe Hospital, Capital Medical University","place":["Beijing, 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