{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:10:26Z","timestamp":1789017026700,"version":"build-2803163510"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Epithelioid hemangioendothelioma (EHE) is a rare low-grade malignant vascular neoplasm characterized by local aggressiveness and metastatic potential. Clinically, EHE may involve multiple anatomical sites\u2014including the lungs, liver, bones, and soft tissues\u2014either synchronously or metachronously. Its non-specific clinical manifestations often complicate early diagnosis. Given the extreme rarity of documented cases in the literature, we report a rare case of right atrial EHE with concurrent bilateral pulmonary and extensive systemic metastases. Furthermore, we present a comprehensive literature review to explore the diagnostic and therapeutic challenges associated with this disease. We particularly emphasize the necessity of a thorough diagnostic evaluation encompassing both pathological and imaging modalities to ensure accurate characterization and diagnosis of the tumor in this case.<\/jats:p>","DOI":"10.3389\/fmed.2026.1897921","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:31:56Z","timestamp":1789014716000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare case report of epithelioid hemangioendothelioma involving both lungs and right atrium with multi-system involvement"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingqing","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Pathology, The Fifth Affiliated Hospital of Dali University","place":["Baoshan, Yunnan Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second Hospital of Baoshan","place":["Baoshan, Yunnan Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiYa","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Fifth Affiliated Hospital of Dali University","place":["Baoshan, Yunnan Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Fifth Affiliated Hospital of Dali University","place":["Baoshan, Yunnan Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Fifth Affiliated Hospital of Dali University","place":["Baoshan, Yunnan Province, 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