{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:30Z","timestamp":1787721690936,"version":"build-2784847793"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Syphilis is caused by\n                    <jats:italic>Treponema pallidum<\/jats:italic>\n                    and progresses through different clinical stages, with a wide range of clinical manifestations. We report a case of secondary syphilis in which the patient presented with diffuse granuloma annulare\u2013like lesions involving the neck, chest, abdomen, back, and upper extremities. Clinically, the lesions manifested as annular plaques with raised erythematous borders, accompanied by central ulceration and necrosis. The diagnosis of secondary syphilis was confirmed by skin biopsy and serological examination. Following treatment with benzathine penicillin G, the non-treponemal test (TRUST) became negative 7\u202fmonths after therapy. The patient responded well to intravenous penicillin treatment, highlighting the importance of early detection and timely therapy in managing syphilis with atypical histopathological features. In recent years, the incidence of syphilis has continued to increase, underscoring the importance of recognizing this clinicopathological presentation. Routine syphilis screening is essential for accurate diagnosis and appropriate treatment.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1899418","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:47:46Z","timestamp":1787719666000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A case of secondary syphilis with clinical manifestations resembling granuloma annulare"],"prefix":"10.3389","volume":"13","author":[{"given":"Ting","family":"Xu","sequence":"first","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)","place":["Bijie, Guizhou, China"]},{"name":"Key Laboratory for Cancer Prevention and Treatment of Guizhou Province","place":["Bijie, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital), Hangzhou Medical College","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital), Hangzhou Medical College","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Ge","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital Bijie Hospital (The First People\u2019s Hospital of Bijie)","place":["Bijie, Guizhou, China"]},{"name":"Key Laboratory for Cancer Prevention and Treatment of Guizhou Province","place":["Bijie, Guizhou, China"]},{"name":"Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital), Hangzhou Medical College","place":["Hangzhou, Zhejiang, China"]},{"name":"Key Laboratory of Precision Medicine for Head and Neck Cancers of Zhejiang Province, Zhejiang Provincial People\u2019s Hospital","place":["Hangzhou, Zhejiang, China"]},{"name":"Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000489910","article-title":"A case of annular elastolytic giant cell granuloma associated with syphilis","volume":"10","author":"Liu","year":"2018","journal-title":"Case Rep 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patterns in mucocutaneous lesions of primary and secondary syphilis: an immunohistochemical and ultrastructural study","volume":"40","author":"Mart\u00edn-Ezquerra","year":"2009","journal-title":"Hum Pathol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1001\/jama.2021.23487","article-title":"Diagnosis and treatment of sexually transmitted infections: a review","volume":"327","author":"Tuddenham","year":"2022","journal-title":"JAMA"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1899418\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:48:10Z","timestamp":1787719690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1899418\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":13,"alternative-id":["10.3389\/fmed.2026.1899418"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1899418","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"article-number":"1899418"}}