{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:30:35Z","timestamp":1786595435944,"version":"build-2736575974"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To highlight that in retinal racemose hemangioma (RRH) complicated by central retinal vein occlusion (CRVO), intravitreal anti-VEGF may only partially resolve macular edema, and timely laser photocoagulation is the decisive adjunct.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 46-year-old female presented with vision loss in the left eye. Fundus examination revealed CRVO and a superotemporal RRH. Optical coherence tomography (OCT) confirmed significant macular edema. After three monthly anti-VEGF injections, hemorrhages subsided partly but macular edema persisted. Subsequently, laser photocoagulation was applied to retinal non-perfusion areas along with continued anti-VEGF therapy, and at 4\u202fmonths the macular edema had completely resolved, accompanied by a marked improvement in visual acuity. At each subsequent follow-up visit, the patient\u2019s ocular status stayed stable, with no evidence of recurrent macular edema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In RRH-associated CRVO, although anti-VEGF therapy effectively managed the acute macular edema, complete resolution required adjunctive laser photocoagulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1902653","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:23:40Z","timestamp":1786595020000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal racemose hemangioma with central retinal vein occlusion: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Ningning","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Puyang Second People's Hospital (The Eye Hospital of Puyang)","place":["Puyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoquan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"National Clinical Research Center for Eye Diseases","place":["Shanghai, China"]},{"name":"Shanghai Key Laboratory of Ocular Fundus Diseases","place":["Shanghai, China"]},{"name":"Shanghai Engineering Center for Visual Science and Photo Medicine","place":["Shanghai, China"]},{"name":"Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1600-0420.2005.00644.x","article-title":"Exudation, response to photocoagulation and spontaneous remission in a case of bilateral racemose haemangioma","volume":"84","author":"Soliman","year":"2006","journal-title":"Acta Ophthalmol Scand"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"102209","DOI":"10.1016\/j.ajoc.2024.102209","article-title":"Macular edema in Wyburn-Mason syndrome: resolution with anti-VEGF intravitreal injections. 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