{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:04:05Z","timestamp":1790057045510,"version":"4.0.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is a chronic skin disorder with systemic inflammation. Previous studies have focused primarily on its allergic characteristics, whereas the accompanying systemic inflammation and potential hypercoagulable state, particularly across different age groups, have received insufficient attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the correlations between AD severity and systemic inflammation, hypercoagulability, and allergic responses, and to evaluate the age-specific predictive value of these biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study enrolled 181 patients with AD and 101 healthy controls. Disease severity was assessed using the Eczema Area and Severity Index (EASI). Blood samples were analyzed for allergic markers (total IgE and absolute eosinophil count), coagulation markers [D-dimer (D-D), fibrinogen degradation products, and D-dimer-to-fibrinogen ratio [DFR]], and systemic inflammation indices [systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and systemic inflammation response index]. Participants were stratified by age (&amp;lt;60 vs.\u2009\u2265\u200960 years). Group comparisons were performed using non-parametric tests, correlations were assessed using Spearman analysis, and predictive performance was evaluated using receiver operating characteristic curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All measured biomarkers were significantly higher in patients with AD than in controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Age stratification revealed age-dependent effects on several biomarkers. In the overall cohort, total IgE, SII, and PLR correlated positively with EASI scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.184, 0.237, 0.266, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05), independent of age. In patients aged \u226560 years, absolute eosinophil count correlated with disease severity (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.248,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05) and predicted moderate-to-severe AD [area under the curve (AUC)\u2009=\u20090.688]. Coagulation markers correlated with severity in both age groups but with distinct predictive patterns: DFR best predicted mild-to-moderate AD in patients &amp;lt;60 years (AUC\u2009=\u20090.723), whereas D-dimer best predicted moderate-to-severe AD in those \u226560 years (AUC\u2009=\u20090.805). Among the inflammation indices, SII and PLR predicted moderate-to-severe AD (AUC\u2009=\u20090.630 and 0.616, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with AD exhibit significant systemic inflammation, a subclinical hypercoagulable state, and enhanced allergic responses. Total IgE, SII, and PLR are reliable age-independent severity biomarkers. The diagnostic utility of coagulation markers and eosinophil counts is age-dependent. Based on these results, we suggest a practical, age-stratified clinical approach. In all patients with AD, total IgE, SII, and PLR were measured as core severity markers. In patients aged &amp;lt;60, DFR (AUC\u2009=\u20090.723) was used to distinguish mild-to-moderate disease. For those aged \u226560, D-dimer (AUC\u2009=\u20090.805) and the absolute eosinophil count were prioritized (AUC\u2009=\u20090.688) to predict moderate-to-severe AD. Monitoring systemic inflammation and coagulation is clinically relevant, particularly in elderly patients with moderate-to-severe AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1905694","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:37:30Z","timestamp":1790055450000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-stratified correlations between atopic dermatitis severity and biomarkers: hypercoagulability as a key indicator of severity in older adults"],"prefix":"10.3389","volume":"13","author":[{"given":"Yifang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, First Af\ufb01liated Hospital of Kunming Medical University","place":["Kunming, 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