{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:18:54Z","timestamp":1788153534955,"version":"build-2803163510"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Tai Chi (TC) is a low-impact physical activity known to improve balance, strength, and cognitive health across the lifespan. We previously reported that 8 weeks of TC altered brain connectivity and circulating oxylipins (OxLs) and endocannabinoids\/endocannabinoid-like compounds (eCBs) in postmenopausal (PM) women with knee osteoarthritis. This pilot study examined whether a short TC intervention similarly affects inflammatory OxL and eCB in PM women. Participants completed four TC sessions on non-consecutive days over 10 days. Each session included 10 min of warm-up, 45 min of 24-form Yang-style TC (six repetitions at ~7 min per routine), and 5 min of cool-down. Non-fasting plasma collected at baseline and immediately after the fourth session was analyzed for OxL and eCB using targeted metabolomics. Partial least squares discriminant analysis (PLS-DA) assessed pre-to post-intervention differences, and paired\n                    <jats:italic>t<\/jats:italic>\n                    -tests with false discovery rate correction evaluated metabolite changes. Sixteen PM women (58.9 \u00b1 5.2 years; BMI 33.6 \u00b1 5.4 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) completed the study. Several OxLs demonstrated PLS-DA variable importance in projection scores &amp;gt;1.0. Post-intervention, 1-AG and 12-hydroxyeicosatetraenoic acid (12-HETE) were generally lower, whereas 18-HEPE was higher. TC produced modest effects on eCBs but more pronounced changes in OxLs. Reduced monoacylglycerols may indicate TC-induced mobilization of fatty acids through enzymes involved in 1-AG metabolism, including phospholipase C, diacylglycerol lipase-\u03b1, monoglyceride lipase, and potentially fatty acid amide hydrolase.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1907924","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:29:34Z","timestamp":1788150574000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tai Chi exercise of short duration alters circulating oxylipins in postmenopausal women: a pilot study"],"prefix":"10.3389","volume":"13","author":[{"given":"Chwan-Li","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Pathology, Texas Tech University Health Sciences Center","place":["Lubbock, TX, United States"]},{"name":"Center of Excellence for Integrative Health, Texas Tech University Health Sciences 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