{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:13:38Z","timestamp":1788513218666,"version":"build-2803163510"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Calcium ions (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) are pleiotropic signaling messengers that regulate diverse cellular processes, and their homeostasis is essential for normal physiology at cellular, tissue, and organismal levels. Accumulating evidence identifies Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dysregulation as a key driver of sepsis onset and progression. In this review, we systematically delineate the mechanisms governing intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis, focusing on coordinated regulation among the endoplasmic reticulum, mitochondria, and lysosomes. We also discuss the molecular basis of disordered Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling in sepsis-associated pathologies and summarize recent therapeutic strategies targeting Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis, together with their translational prospects and challenges. Unlike prior reviews focusing on single organelles or individual organs, this review provides an integrative framework for organellar Ca\n                    <jats:sup>2+<\/jats:sup>\n                    communication in sepsis. We propose that inflammatory insults progressively disrupt coordinated inter-organellar Ca\n                    <jats:sup>2+<\/jats:sup>\n                    exchange, switching physiological coupling toward pathological states. Such aberrant inter-organellar crosstalk initiates a self-amplifying vicious cycle that ultimately propagates cellular injury to systemic multi-organ failure. Collectively, further exploration of dynamic organellar interplay within the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    regulatory network may yield new mechanistic insights and facilitate precise therapeutic strategies for sepsis.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2026.1910574","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:24:06Z","timestamp":1788510246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcium homeostasis imbalance in sepsis: molecular mechanisms and therapeutic perspectives"],"prefix":"10.3389","volume":"13","author":[{"given":"Rong","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gu","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Laboratory, School of Life Sciences, Jiangsu University","place":["Zhenjiang, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1056\/NEJMra2403213","article-title":"Sepsis and septic shock","volume":"391","author":"Meyer","year":"2024","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s40779-024-00581-0","article-title":"Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations","volume":"11","author":"Xu","year":"2024","journal-title":"Mil Med Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1560737","DOI":"10.3389\/fmed.2025.1560737","article-title":"Sepsis and post-sepsis 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