{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:58Z","timestamp":1789448578576,"version":"build-2803163510"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ischemic central retinal vein occlusion (ischemic CRVO) is a severe, vision-threatening vascular event. While most cases stem from conventional cardiovascular or local anatomical etiologies, its presentation in association with relapsed mantle cell lymphoma (MCL) and suspected cancer-associated hypercoagulability is rare. This report highlights that retinal vascular occlusion in a patient with relapsed MCL represents a rare ocular manifestation of severe systemic prothrombotic activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>An 89-year-old male with established stage IV MCL (CD20+, cyclin D1+, SOX-11+, Ki-67\u223c10%), whose systemic relapse had been documented 6 months prior, developed sudden, painless vision loss in his right eye (best-corrected visual acuity, BCVA 0.01) while hospitalized for disease management. Multimodal ophthalmic examination and optical coherence tomography (OCT) supported the diagnosis of ischemic CRVO with prominent macular edema. Laboratory workup revealed marked coagulation abnormalities (D-dimer 4.34\u2005mg\/L FEU, Fibrinogen Equivalent Units; antithrombin activity 78%). Cranial MRI (magnetic resonance imaging) revealed multifocal chronic\/non-acute ischemic cerebral changes and periventricular leukoaraiosis without acute diffusion restriction. Following a localized peribulbar injection of triamcinolone acetonide (20\u2005mg), right eye BCVA improved to 0.1, with anatomical reduction of retinal edema. Prophylactic panretinal photocoagulation (PRP) was unfeasible due to posterior capsular opacification and severe systemic frailty. Four months later, the patient developed neovascular glaucoma requiring cyclocryotherapy for palliative pain management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with active relapsed MCL, ischemic CRVO may occur as a focal manifestation of a generalized prothrombotic state. When severe retinal vascular occlusion presents in patients with advanced hematological malignancies, systemic coagulation assessment and neuroimaging evaluation should be considered to identify underlying prothrombotic risks and subclinical cerebrovascular disease, even in the absence of overt focal neurological deficits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1926148","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:27:11Z","timestamp":1789446431000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Ischemic central retinal vein occlusion in a patient with relapsed mantle cell lymphoma as a manifestation of suspected cancer-associated hypercoagulability"],"prefix":"10.3389","volume":"13","author":[{"given":"Chaoxiong","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shandong Second Medical University Affilliated Qingdao Eighth People's Hospital - East Campus","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital)","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.preteyeres.2004.12.001","article-title":"Prevalent misconceptions about acute retinal vascular occlusive disorders","volume":"24","author":"Hayreh","year":"2005","journal-title":"Prog Retinal Eye Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.ophtha.2010.01.060","article-title":"Natural history of central retinal vein occlusion: an evidence-based systematic review","volume":"117","author":"McIntosh","year":"2010","journal-title":"Ophthalmology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.medcli.2009.05.043","article-title":"Vascular risk factors and retinal occlusive disease","volume":"134","author":"Rodr\u00edguez Gaspar","year":"2010","journal-title":"Med Clin"},{"key":"B4","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0002-9394(99)80192-5","article-title":"Ocular manifestations of giant cell arteritis","volume":"125","author":"Hayreh","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/jth.12075","article-title":"Coagulation and cancer: biological and clinical aspects","volume":"11","author":"Falanga","year":"2013","journal-title":"J Thromb Haemost"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1200\/JCO.2015.63.5904","article-title":"Mantle cell lymphoma","volume":"34","author":"Cheah","year":"2016","journal-title":"J Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1161\/STROKEAHA.114.005784","article-title":"Cryptogenic subtype predicts reduced survival among cancer patients with ischemic stroke","volume":"45","author":"Navi","year":"2014","journal-title":"Stroke"},{"key":"B8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000492832","article-title":"Blastic transformation of a mantle cell lymphoma presenting as an enlarging unilateral orbital mass","volume":"5","author":"De Niear","year":"2019","journal-title":"Ocular Oncol Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"iv62","DOI":"10.1093\/annonc\/mdx223","article-title":"Newly diagnosed and relapsed mantle cell lymphoma: eSMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Dreyling","year":"2017","journal-title":"Ann Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41572-022-00336-y","article-title":"Cancer-associated venous thromboembolism","volume":"8","author":"Khorana","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.1016\/S1470-2045(22)00160-7","article-title":"2022 International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19","volume":"23","author":"Farge","year":"2022","journal-title":"Lancet Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1182\/blood.2020006844","article-title":"A randomized phase 3 trial of zanubrutinib vs ibrutinib in symptomatic waldenstr\u00f6m macroglobulinemia: the ASPEN study","volume":"136","author":"Tam","year":"2020","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2147\/OPTH.S170562","article-title":"Comparison between intravitreal bevacizumab and posterior sub-tenon injection of triamcinolone acetonide in macular edema secondary to retinal vein occlusion","volume":"12","author":"Tsai","year":"2018","journal-title":"Clin Ophthalmol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9394(14)70001-7","article-title":"Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics","volume":"117","author":"Hayreh","year":"1994","journal-title":"Am J Ophthalmol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1926148\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:27:12Z","timestamp":1789446432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1926148\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":14,"alternative-id":["10.3389\/fmed.2026.1926148"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1926148","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"article-number":"1926148"}}