{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:04:29Z","timestamp":1789362269829,"version":"build-2803163510"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between risk-weighted apolipoprotein B (RW-apoB) levels and prevalent kidney stones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective case-control study included 761 subjects, comprising a non-stone group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009522) and an incident kidney stone group confirmed strictly by non-contrast computed tomography (NCCT) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009239). Multivariable logistic regression models were utilized to evaluate the association between RW-apoB and prevalent kidney stones. To address unmeasured confounding from potential lipid-lowering therapies, a sensitivity analysis was conducted by excluding individuals with comorbid hypertension and diabetes. Additionally, subgroup analyses were performed to assess the stability of this association across different clinical characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline analysis revealed that RW-apoB levels in the kidney stone group were significantly higher than those in the non-stone group (95.89\u2009\u00b1\u200928.80 vs. 88.52\u2009\u00b1\u200924.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Multivariable logistic regression analysis indicated that continuously elevated RW-apoB levels were significantly associated with prevalent kidney stones (OR\u2009=\u20091.01, 95% CI: 1.00\u20131.02). In the strict sensitivity analysis excluding hypertensive and diabetic patients, this positive association remained consistent (OR\u2009=\u20091.01, 95% CI: 1.00\u20131.03). Furthermore, stratified analysis demonstrated that this positive association between RW-apoB and kidney stones remained relatively consistent across subgroups defined by age, gender, and metabolic comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher RW-apoB was associated with prevalent kidney-stone status after adjustment for measured clinical covariates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1927930","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:33:08Z","timestamp":1789360388000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between risk-weighted apolipoprotein B and prevalent kidney stones: a retrospective case-control study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaogang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, Anhui, China"]},{"name":"Department of Urology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University","place":["Huangshi, Hubei, China"]},{"name":"Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention","place":["Huangshi, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shen","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention","place":["Huangshi, Hubei, China"]},{"name":"Department of Hepatobiliary, Urologic, and Gynecologic Oncology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University","place":["Huangshi, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University","place":["Huangshi, Hubei, China"]},{"name":"Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention","place":["Huangshi, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Huangshi Central Hospital Graduate Joint Training Base, School of Medicine, Wuhan University of Science and Technology","place":["Huangshi, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiankun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Huangshi Central Hospital Graduate Joint Training Base, School of Medicine, Wuhan University of Science and Technology","place":["Huangshi, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University","place":["Huangshi, Hubei, China"]},{"name":"Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention","place":["Huangshi, Hubei, China"]},{"name":"Department of Urology, Huangshi Central Hospital Graduate Joint Training Base, School of Medicine, Wuhan University of Science and Technology","place":["Huangshi, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiansheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, Anhui, 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