{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:04:56Z","timestamp":1790057096195,"version":"4.0.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate the association between estimated pulse wave velocity (ePWV) and new-onset heart failure (HF) in ICU patients with acute myocardial infarction (AMI), and to evaluate its incremental predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ICU patients with AMI were identified from the eICU-CRD cohort, and an independent real-world ICU cohort was used for external validation. New-onset HF was the primary outcome. Multivariable regression models were used to assess the association between ePWV and new-onset HF across different time periods. Restricted cubic spline analysis was performed to evaluate the dose-response relationship, and incremental value analysis was conducted to determine the added predictive value of ePWV beyond traditional risk models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the eICU-CRD cohort, the incidence of new-onset HF was 10.2%. After full adjustment, each 1-unit increase in ePWV was associated with a 13% higher risk of in-hospital heart failure (HR\u2009=\u20091.13, 95% CI: 1.09\u20131.18,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), and the high-ePWV group had a significantly increased risk (HR\u2009=\u20091.84, 95% CI: 1.50\u20132.24,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). In the validation cohort, the incidence of heart failure was 12.9%; each 1-unit increase in ePWV was associated with a 16% higher risk (OR\u2009=\u20091.16, 95% CI: 1.01\u20131.35,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.046), and the high-ePWV group also showed increased risk (OR\u2009=\u20092.21, 95% CI: 1.02\u20134.78,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.044). ePWV showed a nonlinear positive association with heart failure risk, and significantly improved model discrimination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher ePWV was independently and nonlinearly associated with in-hospital new-onset HF among ICU patients with AMI and improved risk discrimination beyond conventional clinical models. Its association with 1-year post-discharge HF in this high-risk population showed a consistent direction but requires further validation in larger prospective cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1930499","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:40:27Z","timestamp":1790055627000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimated pulse wave velocity and risk of new-onset heart failure in ICU patients with acute myocardial infarction: a multicenter cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Huijian","family":"Wang","sequence":"first","affiliation":[{"name":"JiuJiang City Key Laboratory of Cell Therapy, Department of Cardiovascular Medicine, Jiujiang No. 1 People's Hospital","place":["Jiujiang, Jiangxi, China"]},{"name":"Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyuan","family":"Li","sequence":"additional","affiliation":[{"name":"JiuJiang City Key Laboratory of Cell Therapy, Department of Cardiovascular Medicine, Jiujiang No. 1 People's Hospital","place":["Jiujiang, Jiangxi, China"]},{"name":"Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, Jiangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"He","sequence":"additional","affiliation":[{"name":"JiuJiang City Key Laboratory of Cell Therapy, Department of Cardiovascular Medicine, Jiujiang No. 1 People's Hospital","place":["Jiujiang, Jiangxi, 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