{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:06:00Z","timestamp":1790172360319,"version":"4.1.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Fournier's gangrene is typically polymicrobial necrotizing fasciitis of the perineal\/genital regions.\n                      <jats:italic>Gleimia hominis<\/jats:italic>\n                      (Actinomycetaceae) is a rare anaerobic Gram-positive rod whose clinical role remains poorly defined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 71-year-old man with Parkinson disease, dementia, and chronic obstructive pulmonary disease was transferred for worsening fever and perineal swelling despite 6 days of piperacillin-tazobactam. Computed tomography showed a rim-enhancing fluid collection extending from the left lower abdominal wall to the left hemiscrotum with gas formation. Fournier's gangrene was diagnosed, and empiric meropenem was started together with surgical incision and drainage.\n                      <jats:italic>G. hominis<\/jats:italic>\n                      was isolated from the abscess culture and identified by matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry. Antimicrobial therapy was de-escalated to ampicillin-sulbactam, followed by oral amoxicillin-clavulanate, with clinical improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case highlights the pathogenic potential of\n                      <jats:italic>G. hominis<\/jats:italic>\n                      in necrotizing soft tissue infection and the value of precise microbiologic identification for antimicrobial de-escalation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1933680","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:28:01Z","timestamp":1790170081000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Fournier's gangrene caused by Gleimia hominis"],"prefix":"10.3389","volume":"13","author":[{"given":"Jin Woong","family":"Suh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Kyung Hee University School of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Seong","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kyung Hee University School of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-youn","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kyung Hee University School of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11934-025-01275-3","article-title":"Modern management of Fournier's gangrene","volume":"26","author":"Kopechek","year":"2025","journal-title":"Curr Urol Rep"},{"key":"B2","article-title":"Fournier gangrene","volume-title":"StatPearls","author":"Leslie","year":"2026"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1016\/j.juro.2009.01.034","article-title":"Fournier's gangrene: population based epidemiology and outcomes","volume":"181","author":"Sorensen","year":"2009","journal-title":"J Urol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4081\/aiua.2016.3.157","article-title":"Fournier's gangrene. A clinical review","volume":"88","author":"Singh","year":"2016","journal-title":"Arch Ital Urol Androl"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s40121-023-00781-6","article-title":"Fournier's gangrene with growth of Actinomyces europaeus: a case report","volume":"12","author":"Zhang","year":"2023","journal-title":"Infect Dis Ther"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e946","DOI":"10.1093\/ajhp\/zxaf190","article-title":"Treatment of Actinomyces europaeus and Clostridium innocuum necrotizing fasciitis: case report and literature review","volume":"82","author":"Avery","year":"2025","journal-title":"Am J Health Syst Pharm"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2354148","DOI":"10.1080\/20002297.2024.2354148","article-title":"Polymicrobial infections with specific Actinomyces and related organisms, using the current taxonomy","volume":"16","author":"Kononen","year":"2024","journal-title":"J Oral Microbiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.3390\/antibiotics9080524","article-title":"The pathogenic role of Actinomyces spp. and related organisms in genitourinary infections: discoveries in the new, modern diagnostic era","volume":"9","author":"Gajdacs","year":"2020","journal-title":"Antibiotics (Basel)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e77128","DOI":"10.7759\/cureus.77128","article-title":"Actinomyces species as emerging pathogens: an observational study of clinical infections and microbiological implications","volume":"17","author":"Ayantunde","year":"2025","journal-title":"Cureus"},{"key":"B10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2147\/IDR.S39601","article-title":"Actinomycosis: etiology, clinical features, diagnosis, treatment, and management","volume":"7","author":"Valour","year":"2014","journal-title":"Infect Drug Resist"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1099\/ijs.0.015818-0","article-title":"Actinomyces hominis sp. nov., isolated from a wound swab","volume":"60","author":"Funke","year":"2010","journal-title":"Int J Syst Evol Microbiol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1933680\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:28:04Z","timestamp":1790170084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1933680\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":11,"alternative-id":["10.3389\/fmed.2026.1933680"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1933680","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"article-number":"1933680"}}