{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:04:04Z","timestamp":1790661844293,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007365","name":"Fondazione IRCCS Policlinico San Matteo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lymphomatoid papulosis (LyP) is a rare CD30-positive cutaneous T-cell lymphoproliferative disorder, extremely uncommon in children and adolescents. Despite its indolent course, LyP may mimic malignant lymphomas clinically and histopathologically, making diagnosis challenging in pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the clinical, histopathologic, immunophenotypic and molecular features of pediatric LyP and to describe treatment approaches and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective observational study of pediatric patients with clinicopathologically confirmed LyP evaluated at our tertiary referral center between 2004 and 2025. Demographic, clinical, histopathologic, immunophenotypic, molecular, treatment and follow-up data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine patients were included (8 males, 1 female), with a median age at diagnosis of 11 years (range 2\u201318). Lesions predominantly involved the limbs (9\/9, 100%), followed by the trunk (5\/9, 56%) and hands (4\/9, 44%). Ulceration or necrotic evolution occurred in 6\/9 patients (67%). Type A was the most common histologic subtype (5\/9, 56%), followed by single cases of types B, D, E and one overlap A\u2013C case. CD30 expression was observed in all patients. T-cell receptor clonality was identified in 4\/5 tested cases. Management was mainly conservative, consisting of topical corticosteroids and phototherapy (nbUVB or PUVA). Methotrexate was used in one patient. At the last follow-up, all patients were free of active LyP lesions, and no associated hematologic malignancy was documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pediatric LyP shows heterogeneous clinicopathologic features with overall favorable outcomes. However, long-term follow-up remains warranted due to the lifelong risk of associated lymphoproliferative disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1948975","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:46:11Z","timestamp":1790660771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric lymphomatoid papulosis: a broad clinicopathologic spectrum including rare variants in a single-center case series"],"prefix":"10.3389","volume":"13","author":[{"given":"Margherita","family":"Pelucchi","sequence":"first","affiliation":[{"name":"Dermatology Unit, Fondazione IRCCS Policlinico San Matteo","place":["Pavia, Italy"]},{"name":"Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia","place":["Pavia, 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Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Brazzelli","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Fondazione IRCCS Policlinico San Matteo","place":["Pavia, Italy"]},{"name":"Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia","place":["Pavia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"B2","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/bjd\/ljae150","article-title":"Paediatric-onset lymphomatoid papulosis: results of a multicentre retrospective cohort study on 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