{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:08:28Z","timestamp":1789380508017,"version":"build-2803163510"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Structural healing after rotator cuff repair is clinically important, yet individual healing trajectories remain difficult to predict, monitor, and translate into individualized care. Evidence spans routine clinical predictors, systemic metabolic biomarkers, quantitative imaging, tissue phenotypes, genetic variation, transcriptomic signatures, and artificial intelligence\u2013based prediction models. However, prior reviews rarely distinguish these evidence objects or evaluate them according to intended clinical use and stage of validation. This focused Mini Review assesses readiness for precision care across five linked dimensions: measurement validity, context-specific clinical validity, added value beyond routine predictors, independent validation, and action or impact evidence. Current literature is dominated by prognostic associations and model-development studies, whereas routine clinical predictors remain the most mature benchmarks. Promising signals have emerged across modalities, but heterogeneous structural endpoints, inconsistent measurement procedures, limited external validation, and the absence of decision-linked impact studies continue to impede individualized care. The principal challenge is therefore not candidate scarcity, but conversion of associations into reproducible, transportable, and actionable evidence. By mapping each evidence class to prognosis, monitoring, diagnosis, or treatment-effect prediction, this review proposes a translational roadmap for biomarker-informed risk stratification, postoperative surveillance, and prospective evaluation of individualized management pathways.<\/jats:p>","DOI":"10.3389\/fmed.2026.1955208","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:01:22Z","timestamp":1789380082000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural healing after rotator cuff repair: clinical predictors, biomarkers, prediction models, and readiness for precision care"],"prefix":"10.3389","volume":"13","author":[{"given":"Qin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/1758573217731548","article-title":"Does structural integrity following rotator cuff repair affect functional outcomes and pain scores? 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