{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:57Z","timestamp":1789448577493,"version":"build-2803163510"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) increases the risk of sarcopenia, which independently contributes to bone fragility, especially among the elderly. Bone mineral content (BMC) is a parameter that helps in the assessment and monitoring of bone mass. This study aims to identify the correlation between BMC and sarcopenia in hospitalized patients with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A total of 1,135 inpatients admitted with T2DM in this study and classified into two groups (sarcopenia and non-sarcopenia group). A comparative analysis of clinical data and body composition was performed between the two groups. A multivariable logistic regression model was used to assess the independent association of BMC with sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sarcopenia group showed a lower BMC level than the non-sarcopenia group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). The BMC level was correlated with a history of sarcopenia (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). The receiver operator characteristic (ROC) curve analysis showed a medium ability of BMC in predicting sarcopenia (area under the ROC curve=0.760). The optimal cut-off level for BMC to predict sarcopenia was found to be\u2009&amp;lt;\u20092.86\u2005kg. Finally, in the multivariable logistic regression model, a BMC level &amp;lt; 2.86\u2005kg was significantly associated with sarcopenia [odds ratio (OR)\u2009=\u20094.994, 95% confidence interval [CI] 3.130\u20137.967,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001]. Additional analyses revealed that lower BMC level was associated with an increased risk of sarcopenia irrespective of the subgroup of age (including elderly group and non-elderly group).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results confirmed that in hospitalized patients with T2DM, BMC levels are inversely associated with sarcopenia and may therefore serve as a biomarker for sarcopenia discrimination. But additional studies are needed to confirm and further elucidate our results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1956269","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:26:47Z","timestamp":1789446407000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between bone mineral content and sarcopenia in hospitalized patients with type 2 diabetes mellitus: a cross-sectional study"],"prefix":"10.3389","volume":"13","author":[{"given":"Wei","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, the First Affiliated Hospital of Soochow University","place":["Suzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Xia","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the First Affiliated Hospital of Soochow University","place":["Suzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Hospital of Soochow University","place":["Suzhou, Jiangsu, China"]},{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University","place":["Suzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Qiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Abdominal and Pelvic Tumor Treatment, The Second Affiliated Hospital of Soochow University","place":["Suzhou, Jiangsu, China"]},{"name":"Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University","place":["Suzhou, Jiangsu, China"]},{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University","place":["Suzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41574-022-00690-7","article-title":"The burden and risks of emerging complications of diabetes mellitus","volume":"18","author":"Tomic","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1093\/gerona\/glx245","article-title":"Associations of sarcopenia definitions, and their components, with the incidence of recurrent falling and fractures: the longitudinal aging study Amsterdam","volume":"73","author":"Schaap","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.14283\/jfa.2017.30","article-title":"Implications of ICD-10 for sarcopenia clinical practice and clinical trials: report by the international conference on frailty and sarcopenia research task force","volume":"7","author":"Vellas","year":"2018","journal-title":"J Frailty Aging"},{"key":"B4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/nu13010183","article-title":"A narrative review on sarcopenia in type 2 diabetes Mellitus: prevalence and associated factors","volume":"13","author":"Izzo","year":"2021","journal-title":"Nutrients"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0257955","DOI":"10.1371\/journal.pone.0257955","article-title":"Can fngernail quality predict bone damage in type 2 diabetes mellitus? 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