{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:29Z","timestamp":1787721689262,"version":"build-2784847793"},"reference-count":6,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2026.1959510","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:45:39Z","timestamp":1787719539000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Editorial: Organoids and 3D culture: bridging tissue complexity in biomedical research"],"prefix":"10.3389","volume":"13","author":[{"given":"Bianca","family":"Vezzani","sequence":"first","affiliation":[{"name":"Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis","place":["MN, United States"]},{"name":"Department of Medicine and Surgery, University of Parma","place":["Parma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Genovese","sequence":"additional","affiliation":[{"name":"Departmental Faculty of Medicine UniCamillus-Saint Camillus International University of Health Sciences","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrm3873","article-title":"Three-dimensional organotypic culture: experimental models of mammalian biology and disease","volume":"15","author":"Shamir","year":"2014","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1038\/nprot.2014.158","article-title":"Generation of cerebral organoids from human pluripotent stem cells","volume":"9","author":"Lancaster","year":"2014","journal-title":"Nat Protoc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature."},{"key":"B4","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1158\/2159-8290.CD-16-1154","article-title":"Personalized in vitro and in vivo cancer models to guide precision medicine","volume":"7","author":"Pauli","year":"2017","journal-title":"Cancer Discov."},{"key":"B5","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1126\/science.aao2774","article-title":"Patient-derived organoids model treatment response of metastatic gastrointestinal cancers","volume":"359","author":"Vlachogiannis","year":"2018","journal-title":"Science."},{"key":"B6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41578-021-00279-y","article-title":"Engineering organoids","volume":"6","author":"Hofer","year":"2021","journal-title":"Nat Rev Mater."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1959510\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:46:01Z","timestamp":1787719561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1959510\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":6,"alternative-id":["10.3389\/fmed.2026.1959510"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1959510","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"article-number":"1959510"}}