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Some leukemia cases may become resistant to existing treatments over time making them less susceptible to chemotherapy or other standard therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Developing new treatment strategies to overcome resistance is an ongoing challenge particularly in Low and Middle Income Countries (LMICs). Computational studies using COMSOL software could provide an economical, fast and resourceful approach to the treatment of complicated cancers like leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using COMSOL Multiphysics software, a continuous flow microfluidic device capable of delivering anti-leukemia drugs to early-stage leukemia cells has been computationally modeled using dielectrophoresis (DEP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cell size difference enabled the micro-particle drug attachment to the leukemia cells using hydrodynamic focusing from the dielectrophoretic force. This point of care application produced a low voltage from numerically calculated electrical field and flow speed simulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, such a dielectrophoretic low voltage application model can be used as a computational treatment reference for early-stage leukemia cells with an approximate size of 5\u2005\u03bcm.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmedt.2023.1250964","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T17:00:54Z","timestamp":1697130054000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A di-electrophoretic simulation procedure of iron-oxide micro-particle drug attachment system for leukemia treatment using COMSOL software: a potential treatment reference for LMICs"],"prefix":"10.3389","volume":"5","author":[{"given":"Henry Fenekansi","family":"Kiwumulo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Muwonge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Ibingira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lubwama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Baptist","family":"Kirabira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Tamale","family":"Ssekitoleko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/jgo.17.00193","article-title":"Implementing a childhood cancer outcomes surveillance system within a population-based cancer registry","volume":"4","author":"Ramirez","year":"2018","journal-title":"J Glob Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.drudis.2015.05.009","article-title":"Metal nanoparticles: a theranostic nanotool against cancer","volume":"20","author":"Sharma","year":"2015","journal-title":"Drug Discov Today"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/jgo.17.00095","article-title":"Establishing a pediatric hematology-oncology program in Botswana","volume":"4","author":"Slone","year":"2018","journal-title":"J Glob Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules27041310","article-title":"Targeted drug delivery for the treatment of blood cancers","volume":"27","author":"Jiang","year":"2022","journal-title":"Molecules"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102678","article-title":"Epigenetic activation of O-linked \u03b2-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia","volume":"54","author":"Kampa-Schittenhelm","year":"2020","journal-title":"EBioMedicine"},{"key":"B6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1177\/1078155217710553","article-title":"BCR-ABL1 tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia","volume":"24","author":"Cuellar","year":"2018","journal-title":"J Oncol Pharm Pract"},{"key":"B7","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s11136-019-02351-1","article-title":"Is quality of life after mastectomy comparable to that after breast conservation surgery? 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