{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:06:12Z","timestamp":1774940772079,"version":"3.50.1"},"reference-count":127,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med. Technol."],"abstract":"<jats:p>Osteomyelitis is a severe bone infection caused by bacterial invasion, posing significant therapeutic challenges due to biofilm formation and antibiotic resistance. In recent years, nanozymes\u2014a class of functional nanomaterials with enzyme-like catalytic activities\u2014have shown considerable potential in antimicrobial applications owing to their high stability, tunable catalytic activity, and low tendency to induce resistance, positioning them as promising alternatives to conventional antibiotics. This review systematically examines the therapeutic prospects of nanozyme-based delivery systems for treating osteomyelitis. We detail the antibacterial mechanisms of nanozymes exhibiting various enzyme-mimicking activities\u2014primarily peroxidase-, oxidase-, haloperoxidase-, and hydrolase-like functionalities\u2014such as generating reactive oxygen species (ROS) by catalyzing endogenous hydrogen peroxide and physically degrading biofilm components. This review aims to provide a theoretical foundation and novel insights for developing efficient and safe nanozyme-based antimicrobial agents against osteomyelitis.<\/jats:p>","DOI":"10.3389\/fmedt.2026.1779701","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:34:12Z","timestamp":1774935252000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the treatment of osteomyelitis based on nanozyme-based antibacterial strategies"],"prefix":"10.3389","volume":"8","author":[{"given":"Junzhen","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Xinmin Orthopedic, China-Japan Union Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Xinmin Orthopedic, China-Japan Union Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Xinmin Orthopedic, China-Japan Union Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yisi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Xinmin Orthopedic, China-Japan Union Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Xinmin Orthopedic, China-Japan Union Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2106\/jbjs.N.01350","article-title":"Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009","volume":"97","author":"Kremers","year":"2015","journal-title":"J Bone Joint Surg Am"},{"key":"B2","doi-asserted-by":"publisher","first-page":"254.e1","DOI":"10.1016\/j.cmi.2014.09.007","article-title":"The changing epidemiology of bacteraemic osteoarticular infections in the early 21st century","volume":"21","author":"Murillo","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"B3","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s12879-021-06274-6","article-title":"What is the burden of osteomyelitis in Germany? 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