{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:15:07Z","timestamp":1779376507026,"version":"3.53.1"},"reference-count":49,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2015.00973","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T09:03:30Z","timestamp":1443431010000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Oleylphosphocholine (OlPC) arrests Cryptosporidium parvum growth in vitro and prevents lethal infection in interferon gamma receptor knock-out mice"],"prefix":"10.3389","volume":"6","author":[{"given":"Karine","family":"Sonzogni-Desautels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel E.","family":"Renteria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio V.","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Z.","family":"Di Lenardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mikhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Arrowood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anny","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momar","family":"Ndao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"19686","DOI":"10.1074\/jbc.274.28.19686","article-title":"Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells.","volume":"274","author":"Anthony","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1574-6968.1999.tb08681.x","article-title":"Assessment of drugs against Cryptosporidium parvum using a simple in vitro screening method.","volume":"178","author":"Armson","year":"1999","journal-title":"FEMS Microbiol. Lett."},{"key":"B3","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/S0140-6736(02)07744-9","article-title":"Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study.","volume":"359","author":"Berkman","year":"2002","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1128\/AAC.35.7.1520","article-title":"Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.","volume":"35","author":"Blagburn","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/CMR.00076-12","article-title":"Cryptosporidium pathogenicity and virulence.","volume":"26","author":"Bouzid","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/QCO.0b013e32833de052","article-title":"Treatment of cryptosporidiosis: do we know what we think we know?","volume":"23","author":"Cabada","year":"2010","journal-title":"Curr. Opin. Infect. Dis."},{"key":"B7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-3-7091-1562-6_2","article-title":"\u201cEpidemiology of human cryptosporidiosis,\u201d in","author":"Cacci\u00f2","year":"2014","journal-title":"Cryptosporidium: Parasite and Disease"},{"key":"B8","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.pt.2005.06.013","article-title":"Unravelling Cryptosporidium and Giardia epidemiology.","volume":"21","author":"Cacci\u00f2","year":"2005","journal-title":"Trends Parasitol."},{"issue":"666","key":"B9","article-title":"Investigational drug available directly from CDC for the treatment of infections with free-living amebae.","volume":"62","author":"CDC","year":"2013","journal-title":"MMWR"},{"key":"B10","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.exppara.2009.02.003","article-title":"Minireview: clinical cryptosporidiosis.","volume":"124","author":"Chalmers","year":"2010","journal-title":"Exp. Parasitol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1056\/NEJMra013170","article-title":"Cryptosporidiosis.","volume":"346","author":"Chen","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s10096-010-0960-9","article-title":"Cryptosporidiosis: environmental, therapeutic, and preventive challenges.","volume":"29","author":"Collinet-Adler","year":"2010","journal-title":"Euro. J. Clin. Microbiol. Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1093\/infdis\/jis216","article-title":"Novel in vitro and in vivo models and potential new therapeutics to break the vicious cycle of Cryptosporidium infection and malnutrition.","volume":"205","author":"Costa","year":"2012","journal-title":"J. Infect. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1093\/jac\/dks275","article-title":"Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis.","volume":"67","author":"Dorlo","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1128\/AAC.00207-08","article-title":"Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.","volume":"52","author":"Downey","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/S0020-7519(00)00135-1","article-title":"Epidemiology of Cryptosporidium: transmission, detection and identification.","volume":"30","author":"Fayer","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"B17","author":"Fayer","year":"2008","journal-title":"Cryptosporidium and Cryptosporidiosis."},{"key":"B18","author":"FDA","year":"2014","journal-title":"Fda Approves Impavido to Treat Tropical Disease Leishmaniasis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00430-002-0122-5","article-title":"Emerging and re-emerging infectious diseases.","volume":"191","author":"Feldmann","year":"2002","journal-title":"Med. Microbiol. Immunol."},{"issue":"e3144","key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003144","article-title":"Direct comparison of the efficacy and safety of oral treatments with oleylphosphocholine (OlPC) and miltefosine in a mouse model of L. major cutaneous leishmaniasis.","volume":"8","author":"Fortin","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1093\/jac\/dks273","article-title":"Efficacy and tolerability of oleylphosphocholine (OlPC) in a laboratory model of visceral leishmaniasis.","volume":"67","author":"Fortin","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"B22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3201\/eid0301.970106","article-title":"Cryptosporidiosis: an emerging, highly infectious threat.","volume":"3","author":"Guerrant","year":"1997","journal-title":"Emerg. Infect. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"114","DOI":"10.2307\/3284020","article-title":"Therapeutic efficacy of paromomycin in immunosuppressed adult mice infected with Cryptosporidium parvum.","volume":"81","author":"Healey","year":"1995","journal-title":"J. Parasitol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00436-013-3638-2","article-title":"First study on efficacy and tolerability of a new alkylphosphocholine molecule (oleylphosphocholine-OlPC) in the treatment of canine leishmaniosis due to Leishmania infantum.","volume":"113","author":"Hernandez","year":"2014","journal-title":"Parasitol. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1086\/318155","article-title":"Paromomycin: no more effective than placebo for treatment of cryptosporidiosis in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trial Group.","volume":"31","author":"Hewitt","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1128\/AEM.71.7.3848-3857.2005","article-title":"Environmental temperature controls Cryptosporidium oocyst metabolic rate and associated retention of infectivity.","volume":"71","author":"King","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study.","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"B28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/978-3-7091-1562-6_11","article-title":"\u201cTreatment of cryptosporidiosis,\u201d in","author":"Mead","year":"2014","journal-title":"Cryptosporidium: Parasite and Disease"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.2307\/3284643","article-title":"Susceptibility differences to Cryptosporidium parvum infection in two strains of gamma interferon knockout mice.","volume":"84","author":"Mead","year":"1998","journal-title":"J. Parasitol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1128\/AAC.39.4.854","article-title":"Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis.","volume":"39","author":"Mead","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"B31","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2307\/3283888","article-title":"Simplified methods for obtaining purified oocysts from mice and for growing Cryptosporidium parvum in vitro.","volume":"82","author":"Meloni","year":"1996","journal-title":"J. Parasitol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"6063","DOI":"10.1128\/AAC.00734-13","article-title":"A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection.","volume":"57","author":"Ndao","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"issue":"753512","key":"B33","article-title":"Global distribution, public health and clinical impact of the protozoan pathogen Cryptosporidium.","volume":"2010","author":"Putignani","year":"2010","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3945\/jn.113.187161","article-title":"Catch-up growth occurs after diarrhea in early childhood.","volume":"144","author":"Richard","year":"2014","journal-title":"J. Nutr."},{"key":"B35","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1128\/AEM.58.11.3494-3500.1992","article-title":"Survival of Cryptosporidium parvum oocysts under various environmental pressures.","volume":"58","author":"Robertson","year":"1992","journal-title":"Appl. Environ. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0022-1759(91)90114-U","article-title":"An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT.","volume":"142","author":"Roehm","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"B37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.exppara.2009.07.005","article-title":"Cryptosporidium and Giardia: treatment options and prospects for new drugs.","volume":"124","author":"Rossignol","year":"2010","journal-title":"Exp. Parasitol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3201\/eid0802.010164","article-title":"Public health assessment of potential biological terrorism agents.","volume":"8","author":"Rotz","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"B39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-7091-1562-6_1","article-title":"\u201cTaxonomy and molecular taxonomy,\u201d in","author":"Ryan","year":"2014","journal-title":"Cryptosporidium: Parasite and Disease"},{"key":"B40","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.vetpar.2009.03.009","article-title":"Combination of cell culture and quantitative PCR for screening of drugs against Cryptosporidium parvum.","volume":"162","author":"Shahiduzzaman","year":"2009","journal-title":"Vet. Parasitol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-3-7091-1562-6_9","article-title":"\u201cHuman cryptosporidiosis: a clinical perspective,\u201d in","author":"Shikani","year":"2014","journal-title":"Cryptosporidium: Parasite and Disease"},{"key":"B42","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0140-6736(04)15599-2","article-title":"Diarrhoea in children: an interface between developing and developed countries.","volume":"363","author":"Thapar","year":"2004","journal-title":"Lancet"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1093\/infdis\/172.4.1160","article-title":"Evaluation of a two-phase scid mouse model preconditioned with anti-interferon-gamma monoclonal antibody for drug testing against Cryptosporidium parvum.","volume":"172","author":"Tzipori","year":"1995","journal-title":"J. Infect. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.2174\/138161208785294636","article-title":"Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects.","volume":"14","author":"van Blitterswijk","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1017\/S0031182008004757","article-title":"High-yield amplification of Cryptosporidium parvum in interferon \u03b3 receptor knockout mice.","volume":"135","author":"von Oettingen","year":"2008","journal-title":"Parasitology"},{"key":"B46","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1645\/0022-3395(2000)086[0922:HCAICP]2.0.CO;2","article-title":"Host cell apoptosis impairs Cryptosporidium parvum development in vitro.","volume":"86","author":"Widmer","year":"2000","journal-title":"J. Parasitol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"884","DOI":"10.2307\/3284990","article-title":"Infection of immunosuppressed C57BL\/6N adult mice with a single oocyst of Cryptosporidium parvum.","volume":"86","author":"Yang","year":"2000","journal-title":"J. Parasitol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"626","DOI":"10.2307\/3283395","article-title":"The immunosuppressive effects of dexamethasone administered in drinking water to C57BL\/6N mice infected with Cryptosporidium parvum.","volume":"79","author":"Yang","year":"1993","journal-title":"J. Parasitol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1017\/S0031182098003424","article-title":"Characterization of experimental Cryptosporidium parvum infection in IFN-gamma knockout mice.","volume":"117(Pt 6)","author":"You","year":"1998","journal-title":"Parasitology"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T22:24:23Z","timestamp":1599603863000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fmicb.2015.00973\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,23]]},"references-count":49,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2015.00973","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,23]]}}}