{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:17:59Z","timestamp":1787026679603,"version":"build-2736575974"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T00:00:00Z","timestamp":1443052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Muramidase-released protein (MRP) is as an important virulence marker of\n                    <jats:italic>Streptococcus suis (S. suis)<\/jats:italic>\n                    serotype 2. Our previous works have shown that MRP can bind human fibrinogen (hFg); however, the function of this interaction in\n                    <jats:italic>S. suis<\/jats:italic>\n                    meningitis is not known. In this study, we found that the deletion of\n                    <jats:italic>mrp<\/jats:italic>\n                    significantly impairs the hFg-mediated adherence and traversal ability of\n                    <jats:italic>S. suis<\/jats:italic>\n                    across human cerebral microvascular endothelial cells (hCMEC\/D3). Measurement of the permeability to Lucifer yellow\n                    <jats:italic>in vitro<\/jats:italic>\n                    and Evans blue extravasation\n                    <jats:italic>in vivo<\/jats:italic>\n                    show that the MRP-hFg interaction significantly increases the permeability of the blood\u2013brain barrier (BBB). In the mouse meningitis model, wild type\n                    <jats:italic>S. suis<\/jats:italic>\n                    caused higher bacterial loads in the brain and more severe histopathological signs of meningitis than the\n                    <jats:italic>mrp<\/jats:italic>\n                    mutant at day 3 post-infection. Western blot analysis and immunofluorescence observations reveal that the MRP-hFg interaction can destroy the cell adherens junction protein p120-catenin of hCMEC\/D3. These results indicate that the MRP-hFg interaction is important in the development of\n                    <jats:italic>S. suis<\/jats:italic>\n                    meningitis.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2015.01001","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T05:18:44Z","timestamp":1443417524000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["RETRACTED: Interaction of fibrinogen and muramidase-released protein promotes the development of Streptococcus suis meningitis"],"prefix":"10.3389","volume":"6","author":[{"given":"Junping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaijie","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1749-6632.2001.tb03521.x","article-title":"Platelet-fibrinogen interactions","volume":"936","author":"Bennett","year":"2001","journal-title":"Ann. 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