{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:53:57Z","timestamp":1782881637412,"version":"3.54.5"},"reference-count":17,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2015.01193","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T09:38:23Z","timestamp":1446111503000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Immunization with individual proteins of the Lrp\/AsnC family induces protection against Brucella melitensis 16M challenges in mice"],"prefix":"10.3389","volume":"6","author":[{"given":"Xinhui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuxuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhoujia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1046\/j.1365-2958.2003.03442.x","article-title":"The Lrp family of transcriptional regulators","volume":"48","author":"Brinkman","year":"2003","journal-title":"Mol. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.resmic.2005.10.002","article-title":"Surviving inside a macrophage: the many ways of Brucella","volume":"157","author":"Celli","year":"2006","journal-title":"Res. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/cid\/cit251","article-title":"High-risk regions of human brucellosis in china: implications for prevention and early diagnosis of travel-related infections","volume":"57","author":"Chen","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"19462","DOI":"10.1073\/pnas.0807227105","article-title":"Genome-scale reconstruction of the Lrp regulatory network in Escherichia coli","volume":"105","author":"Cho","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B5","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1128\/jb.177.17.4872-4880.1995","article-title":"A consensus sequence for binding of Lrp to DNA","volume":"177","author":"Cui","year":"1995","journal-title":"J. Bacteriol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.jmb.2006.12.032","article-title":"Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly","volume":"366","author":"de los Rios","year":"2007","journal-title":"J. Mol. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1073\/pnas.221575398","article-title":"The genome sequence of the facultative intracellular pathogen Brucella melitensis","volume":"99","author":"DelVecchio","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e29552","DOI":"10.1371\/journal.pone.0029552","article-title":"Immunization of mice with recombinant protein CobB or AsnC confers protection against Brucella abortus infection","volume":"7","author":"Fu","year":"2012","journal-title":"PLoS ONE"},{"key":"B9","doi-asserted-by":"publisher","first-page":"218590","DOI":"10.1155\/2010\/218590","article-title":"Emerging vaccine informatics","volume":"2010","author":"He","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.vetmic.2012.07.016","article-title":"Vaccination with recombinant flagellar proteins FlgJ and FliN induce protection against Brucella abortus 544 infection in BALB\/c mice","volume":"161","author":"Li","year":"2012","journal-title":"Vet. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1128\/IAI.01151-08","article-title":"Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection","volume":"77","author":"Pasquevich","year":"2009","journal-title":"Infect. Immun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"750457","DOI":"10.1155\/2010\/750457","article-title":"The Lrp family of transcription regulators in archaea","volume":"2010","author":"Peeters","year":"2010","journal-title":"Archaea"},{"key":"B14","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1574-6976.2010.00211.x","article-title":"Towards a Brucella vaccine for humans","volume":"34","author":"Perkins","year":"2010","journal-title":"FEMS Microbiol. Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0378-1135(02)00255-9","article-title":"Brucellosis vaccines: past, present and future","volume":"90","author":"Schurig","year":"2002","journal-title":"Vet. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1107\/S0907444901005261","article-title":"Crystallization and quaternary structure analysis of an Lrp-like regulatory protein from the hyperthermophile Pyrococcus furiosus","volume":"57","author":"Sedelnikova","year":"2001","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"B17","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.vetmic.2009.06.021","article-title":"Brucellosis: a re-emerging zoonosis","volume":"140","author":"Seleem","year":"2010","journal-title":"Vet. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T18:28:46Z","timestamp":1498242526000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fmicb.2015.01193\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,29]]},"references-count":17,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2015.01193","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,29]]}}}