{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:40:08Z","timestamp":1781620808723,"version":"3.54.5"},"reference-count":20,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2015.01490","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T09:45:45Z","timestamp":1452246345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Prophylactic Use of Ganoderma lucidum Extract May Inhibit Mycobacterium tuberculosis Replication in a New Mouse Model of Spontaneous Latent Tuberculosis Infection"],"prefix":"10.3389","volume":"6","author":[{"given":"Lingjun","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5603","DOI":"10.1016\/j.bmc.2004.08.004","article-title":"Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood","volume":"12","author":"Chien","year":"2004","journal-title":"Bioorg. Med. Chem"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9966","DOI":"10.3390\/molecules18089966","article-title":"Anti-lung cancer activity through enhancement of immunomodulation and induction of cell apoptosis of total triterpenes extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst","volume":"18","author":"Feng","year":"2013","journal-title":"Molecules"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1038\/sj.gt.3302057","article-title":"Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infection model after aerosol infection of mice with Mycobacterium tuberculosis","volume":"10","author":"Ha","year":"2003","journal-title":"Gene Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.micinf.2008.08.010","article-title":"Guinea pig model of Mycobacterium tuberculosis latent\/dormant infection","volume":"10","author":"Kashino","year":"2008","journal-title":"Microbes Infect."},{"key":"B5","doi-asserted-by":"publisher","first-page":"4945","DOI":"10.1016\/j.vaccine.2010.05.037","article-title":"Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro","volume":"28","author":"Lai","year":"2010","journal-title":"Vaccine"},{"key":"B6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.tube.2004.03.002","article-title":"Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates","volume":"84","author":"Lenaerts","year":"2004","journal-title":"Tuberculosis (Edinb.)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4631","DOI":"10.1128\/IAI.00592-09","article-title":"Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model","volume":"77","author":"Lin","year":"2009a","journal-title":"Infect. Immun"},{"key":"B8","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1189\/jlb.0708441","article-title":"An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways","volume":"86","author":"Lin","year":"2009b","journal-title":"J. Leukoc. Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3881\/j.issn.1000-503X.2011.03.021","article-title":"Effective of Gondeema lucidium preparation in treating simian aquire immune deficiency syndrome","volume":"33","author":"Lu","year":"2011","journal-title":"Acta Acad. Med. Sin"},{"key":"B10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.tube.2007.10.006","article-title":"The aerosol rabbit model of TB latency, reactivation and immune reconstitution inflammatory syndrome","volume":"88","author":"Manabe","year":"2008","journal-title":"Tuberculosis (Edinb.)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.ijbiomac.2011.06.029","article-title":"Analysis of maturation of murine dendritic cells (DCs) induced by purified Ganoderma lucidum polysaccharides (GLPs)","volume":"49","author":"Meng","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e68332","DOI":"10.1371\/journal.pone.0068332","article-title":"Antidiabetic, antihyperlipidemic and antioxidant activities of a novel proteoglycan from Ganoderma lucidum fruiting bodies on db\/db mice and the possible mechanism","volume":"8","author":"Pan","year":"2013","journal-title":"PLoS ONE"},{"key":"B13","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1128\/IAI.67.9.4531-4538.1999","article-title":"Reactivation of latent tuberculosis: variations on the cornell murine model","volume":"67","author":"Scanga","year":"1999","journal-title":"Infect. Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e28082","DOI":"10.1371\/journal.pone.0028082","article-title":"BCG Induces Protection against Mycobacterium tuberculosis Infection in the Wistar rat model","volume":"6","author":"Singhal","year":"2011","journal-title":"PLoS ONE"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1007\/s10529-011-0697-2","article-title":"Polysaccharides purified from the submerged culture of Ganoderma formosanum stimulate macrophage activation and protect mice against Listeria monocytogenes infection","volume":"33","author":"Wang","year":"2011","journal-title":"Biotechnol. Lett"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1128\/IAI.00918-06","article-title":"In vivo adaptation of the Wayne model of latent tuberculosis","volume":"75","author":"Woolhiser","year":"2007","journal-title":"Infect. Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"8535","DOI":"10.1021\/jf100914m","article-title":"Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes","volume":"58","author":"Yeh","year":"2010","journal-title":"J. Agric. Food Chem"},{"key":"B18","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.bbrc.2012.04.135","article-title":"Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi)","volume":"422","author":"Yoshida","year":"2012","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B19","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1164\/rccm.201103-0397OC","article-title":"Short-course chemotherapy with TMC207 and Rifapentine in a murine model of latent tuberculosis infection","volume":"184","author":"Zhang","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/aje\/153.4.381","article-title":"Early therapy for latent tuberculosis infection","volume":"153","author":"Ziv","year":"2001","journal-title":"Am. J. Epidemiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T18:57:21Z","timestamp":1600023441000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fmicb.2015.01490\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,8]]},"references-count":20,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2015.01490","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,8]]}}}