{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T01:30:01Z","timestamp":1772933401686,"version":"3.50.1"},"reference-count":127,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2011 0623"],"award-info":[{"award-number":["PICT 2011 0623"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2013 1049"],"award-info":[{"award-number":["PICT 2013 1049"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2016.00627","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T03:05:36Z","timestamp":1462244736000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii"],"prefix":"10.3389","volume":"7","author":[{"given":"Ignacio M.","family":"Fenoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvina S.","family":"Bogado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana M.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Gottifredi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio O.","family":"Angel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,5,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e41925","DOI":"10.1371\/journal.pone.0041925","article-title":"Characterization of Rad51 from apicomplexan parasite Toxoplasma gondii: an implication for inefficient gene targeting","volume":"7","author":"Achanta","year":"2012","journal-title":"PLoS ONE"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9169","DOI":"10.1073\/pnas.1403565111","article-title":"DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin","volume":"111","author":"Ayrapetov","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1080\/09273940600659740","article-title":"Reactivation of toxoplasma retinochoroiditis under atovaquone therapy in an immunocompetent patient","volume":"14","author":"Baatz","year":"2006","journal-title":"Ocul. Immunol. Inflamm."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e0125358","DOI":"10.1371\/journal.pone.0125358","article-title":"Identification of Plasmodium falciparum DNA repair protein Mre11 with an evolutionarily conserved nuclease function","volume":"10","author":"Badugu","year":"2015","journal-title":"PLoS ONE"},{"key":"B5","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nature03482","article-title":"DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis","volume":"434","author":"Bartkova","year":"2005","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1158\/1535-7163.MCT-12-0707","article-title":"Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer","volume":"12","author":"Batey","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1006\/jmbi.1999.2954","article-title":"Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52","volume":"291","author":"Baumann","year":"1999","journal-title":"J. Mol. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1004086","DOI":"10.1371\/journal.pgen.1004086","article-title":"Is non-homologous end-joining really an inherently error-prone process?","volume":"10","author":"Betermier","year":"2014","journal-title":"PLoS Genet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1128\/EC.5.1.62-76.2006","article-title":"Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii","volume":"5","author":"Bhatti","year":"2006","journal-title":"Eukaryotic Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1042\/BST20120307","article-title":"End-resection at DNA double-strand breaks in the three domains of life","volume":"41","author":"Blackwood","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"B11","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1242\/jcs.00907","article-title":"A domain of Rad9 specifically required for activation of Chk1 in budding yeast","volume":"117","author":"Blankley","year":"2004","journal-title":"J. Cell Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nsmb.2775","article-title":"Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIalpha and RMI1","volume":"21","author":"Bocquet","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0092-8674(01)00536-0","article-title":"Mus81-Eme1 are essential components of a Holliday junction resolvase","volume":"107","author":"Boddy","year":"2001","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1096\/fasebj.11.1.9034168","article-title":"A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins","volume":"11","author":"Bork","year":"1997","journal-title":"FASEB J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1084\/jem.20100244","article-title":"53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination","volume":"207","author":"Bothmer","year":"2010","journal-title":"J. Exp. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/nsmb.1915","article-title":"Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination","volume":"17","author":"Buisson","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.celrep.2014.01.009","article-title":"Breast cancer proteins PALB2 and BRCA2 stimulate polymerase eta in recombination-associated DNA synthesis at blocked replication forks","volume":"6","author":"Buisson","year":"2014","journal-title":"Cell Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2010.03.012","article-title":"53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks","volume":"141","author":"Bunting","year":"2010","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4733","DOI":"10.1016\/j.jmb.2013.04.023","article-title":"Replication stress-induced genome instability: the dark side of replication maintenance by homologous recombination","volume":"425","author":"Carr","year":"2013","journal-title":"J. Mol. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bbagrm.2011.06.006","article-title":"Functions of the Snf2\/Swi2 family Rad54 motor protein in homologous recombination","volume":"1809","author":"Ceballos","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"B21","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.tcb.2015.07.009","article-title":"Repair pathway choices and consequences at the double-strand break","volume":"26","author":"Ceccaldi","year":"2016","journal-title":"Trends Cell Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"22931","DOI":"10.1074\/jbc.R115.675942","article-title":"DNA End Resection: nucleases team up with the right partners to initiate homologous recombination","volume":"290","author":"Cejka","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.molcel.2012.07.029","article-title":"Playing the end game: DNA double-strand break repair pathway choice","volume":"47","author":"Chapman","year":"2012","journal-title":"Mol. Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nrg2193","article-title":"Gene conversion: mechanisms, evolution and human disease","volume":"8","author":"Chen","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"B25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/S0123-9392(12)70018-8","article-title":"Gu\u00eda de atenci\u00f3n integral para la prevenci\u00f3n, detecci\u00f3n temprana y tratamiento de las complicaciones del embarazo, parto y puerperio: secci\u00f3n toxoplasmosis en el embarazo","volume":"16","author":"Cort\u00e9s","year":"2012","journal-title":"Infectio"},{"key":"B26","first-page":"453","article-title":"Investigations of homologous recombination pathways and their regulation","volume":"86","author":"Daley","year":"2013","journal-title":"Yale J. Biol. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1128\/MCB.01639-13","article-title":"53BP1, BRCA1, and the choice between recombination and end joining at DNA double-strand breaks","volume":"34","author":"Daley","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jmb.2009.07.017","article-title":"Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family","volume":"392","author":"Dalmasso","year":"2009","journal-title":"J. Mol. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S1097-2765(01)00175-7","article-title":"Role of BRCA2 in control of the RAD51 recombination and DNA repair protein","volume":"7","author":"Davies","year":"2001","journal-title":"Mol. Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.4161\/cc.6.19.4758","article-title":"The NBS1-ATM connection revisited","volume":"6","author":"Difilippantonio","year":"2007","journal-title":"Cell Cycle"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/nsmb.1916","article-title":"Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2","volume":"17","author":"Dray","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0020-7519(98)00023-X","article-title":"Advances in the life cycle of Toxoplasma gondii","volume":"28","author":"Dubey","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature03445","article-title":"Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy","volume":"434","author":"Farmer","year":"2005","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1073\/pnas.1010959107","article-title":"Rad52 inactivation is synthetically lethal with BRCA2 deficiency","volume":"108","author":"Feng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"99","key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00099","article-title":"Controlling DNA-end resection: a new task for CDKs","volume":"4","author":"Ferretti","year":"2013","journal-title":"Front. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3109\/10409238.2010.488216","article-title":"Oligonucleotide\/Oligosaccharide-Binding (OB) fold proteins: a growing family of genome guardians","volume":"45","author":"Flynn","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1128\/EC.00357-08","article-title":"Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining","volume":"8","author":"Fox","year":"2009","journal-title":"Eukaryotic Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrmicro3184","article-title":"Cell division in apicomplexan parasites","volume":"12","author":"Francia","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1534\/genetics.106.057521","article-title":"A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast","volume":"173","author":"Gabrielse","year":"2006","journal-title":"Genetics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jmb.2011.01.040","article-title":"Operating on chromatin, a colorful language where context matters","volume":"409","author":"Gardner","year":"2011","journal-title":"J. Mol. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.celrep.2013.08.041","article-title":"Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions","volume":"5","author":"Garner","year":"2013","journal-title":"Cell Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S1097-2765(01)00267-2","article-title":"Budding yeast Rad9 is an ATP-dependent Rad53 activating machine","volume":"8","author":"Gilbert","year":"2001","journal-title":"Mol. Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.dnarep.2013.07.006","article-title":"Chromatin structure in double strand break repair","volume":"12","author":"Gospodinov","year":"2013","journal-title":"DNA Repair (Amst)."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.ijpara.2008.06.004","article-title":"The cell cycle and Toxoplasma gondii cell division: tightly knit or loosely stitched?","volume":"38","author":"Gubbels","year":"2008","journal-title":"Int. J. Parasitol."},{"issue":"175","key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00175","article-title":"Is homologous recombination really an error-free process?","volume":"5","author":"Guirouilh-Barbat","year":"2014","journal-title":"Front. Genet."},{"key":"B46","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1098\/rstb.2003.1367","article-title":"Repairing a double-strand chromosome break by homologous recombination: revisiting Robin Holliday's model","volume":"359","author":"Haber","year":"2004","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/jmcb\/mjs066","article-title":"Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair","volume":"5","author":"Hsiao","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nature07215","article-title":"CDK targets Sae2 to control DNA-end resection and homologous recombination","volume":"455","author":"Huertas","year":"2008","journal-title":"Nature"},{"key":"B49","doi-asserted-by":"publisher","first-page":"9558","DOI":"10.1074\/jbc.M808906200","article-title":"Human CtIP mediates cell cycle control of DNA end resection and double strand break repair","volume":"284","author":"Huertas","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1128\/EC.00358-08","article-title":"Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80","volume":"8","author":"Huynh","year":"2009","journal-title":"Eukaryotic Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0022-2836(02)00541-7","article-title":"Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA","volume":"321","author":"Jackson","year":"2002","journal-title":"J. Mol. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"a012740","DOI":"10.1101\/cshperspect.a012740","article-title":"Repair of strand breaks by homologous recombination","volume":"5","author":"Jasin","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nature09399","article-title":"Purified human BRCA2 stimulates RAD51-mediated recombination","volume":"467","author":"Jensen","year":"2010","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3398","DOI":"10.1093\/emboj\/19.13.3398","article-title":"Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells","volume":"19","author":"Johnson","year":"2000","journal-title":"EMBO J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"20130685","DOI":"10.1259\/bjr.20130685","article-title":"DNA DSB repair pathway choice: an orchestrated handover mechanism","volume":"87","author":"Kakarougkas","year":"2014","journal-title":"Br. J. Radiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1016\/j.febslet.2010.07.057","article-title":"Collaboration and competition between DNA double-strand break repair pathways","volume":"584","author":"Kass","year":"2010","journal-title":"FEBS Lett."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1186\/1471-2164-15-1168","article-title":"NextGen sequencing reveals short double crossovers contribute disproportionately to genetic diversity in Toxoplasma gondii","volume":"15","author":"Khan","year":"2014","journal-title":"BMC Genomics"},{"issue":"96","key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2015.00096","article-title":"Regulators of homologous recombination repair as novel targets for cancer treatment","volume":"6","author":"Krajewska","year":"2015","journal-title":"Front. Genet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1126\/science.1103455","article-title":"Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions","volume":"306","author":"Kusch","year":"2004","journal-title":"Science"},{"key":"B60","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.pbiomolbio.2014.12.004","article-title":"Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair","volume":"117","author":"Lafrance-Vanasse","year":"2015","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1038\/emboj.2008.81","article-title":"Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres","volume":"27","author":"Lazzaro","year":"2008","journal-title":"EMBO J."},{"key":"B62","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1128\/MMBR.00059-13","article-title":"DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum","volume":"78","author":"Lee","year":"2014","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B63","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.yexcr.2014.10.008","article-title":"Cycling with BRCA2 from DNA repair to mitosis","volume":"329","author":"Lee","year":"2014","journal-title":"Exp. Cell Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1073\/pnas.1016614108","article-title":"Who's who in human recombination: BRCA2 and RAD52","volume":"108","author":"Liu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B65","doi-asserted-by":"publisher","first-page":"6400","DOI":"10.1158\/1078-0432.CCR-11-3150","article-title":"Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement","volume":"18","author":"Lok","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.meegid.2009.06.024","article-title":"DNA repair mechanisms in eukaryotes: special focus in Entamoeba histolytica and related protozoan parasites","volume":"9","author":"Lopez-Camarillo","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.gde.2013.05.007","article-title":"Break-induced replication: functions and molecular mechanism","volume":"23","author":"Malkova","year":"2013","journal-title":"Curr. Opin. Genet. Dev."},{"key":"B68","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.dnarep.2014.03.013","article-title":"Holliday junction resolution: regulation in space and time","volume":"19","author":"Matos","year":"2014","journal-title":"DNA Repair (Amst)."},{"key":"B69","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.dnarep.2009.12.006","article-title":"Rad54, the motor of homologous recombination","volume":"9","author":"Mazin","year":"2010","journal-title":"DNA Repair (Amst)."},{"key":"B70","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.molcel.2005.10.001","article-title":"Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination","volume":"20","author":"McIlwraith","year":"2005","journal-title":"Mol. Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"a016428","DOI":"10.1101\/cshperspect.a016428","article-title":"Sources of DNA double-strand breaks and models of recombinational DNA repair","volume":"6","author":"Mehta","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1083\/jcb.200708210","article-title":"Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin","volume":"181","author":"Melander","year":"2008","journal-title":"J. Cell Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mrfmmm.2013.07.004","article-title":"Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks","volume":"750","author":"Mermershtain","year":"2013","journal-title":"Mutat. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.tcb.2013.05.006","article-title":"DNA in motion during double-strand break repair","volume":"23","author":"Mine-Hattab","year":"2013","journal-title":"Trends Cell Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1586\/eri.12.58","article-title":"Toxoplasmosis in the fetus and newborn: an update on prevalence, diagnosis and treatment","volume":"10","author":"Moncada","year":"2012","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e1003237","DOI":"10.1371\/journal.pgen.1003237","article-title":"Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid","volume":"9","author":"Munoz-Galvan","year":"2013","journal-title":"PLoS Genet."},{"key":"B77","doi-asserted-by":"publisher","first-page":"e1001232","DOI":"10.1371\/journal.ppat.1001232","article-title":"Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes","volume":"6","author":"Naguleswaran","year":"2010","journal-title":"PLoS Pathog."},{"key":"B78","doi-asserted-by":"publisher","first-page":"e00922","DOI":"10.1128\/mBio.00922-13","article-title":"The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications","volume":"4","author":"Nardelli","year":"2013","journal-title":"MBio"},{"key":"B79","doi-asserted-by":"publisher","first-page":"5017","DOI":"10.1093\/nar\/gkv409","article-title":"The 9-1-1 checkpoint clamp coordinates resection at DNA double strand breaks","volume":"43","author":"Ngo","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1038\/ncomms5091","article-title":"A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice","volume":"5","author":"Pai","year":"2014","journal-title":"Nat. Commun."},{"key":"B81","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1128\/MMBR.63.2.349-404.1999","article-title":"Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae","volume":"63","author":"Paques","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B82","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.bbcan.2014.06.003","article-title":"PALB2: the hub of a network of tumor suppressors involved in DNA damage responses","volume":"1846","author":"Park","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B83","doi-asserted-by":"publisher","first-page":"840768","DOI":"10.4061\/2010\/840768","article-title":"Overview of DNA repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major","volume":"2010","author":"Passos-Silva","year":"2010","journal-title":"J. Nucleic Acids"},{"key":"B84","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)80211-1","article-title":"What's up and down with histone deacetylation and transcription?","volume":"89","author":"Pazin","year":"1997","journal-title":"Cell"},{"key":"B85","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jmb.2006.06.020","article-title":"CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing","volume":"361","author":"Petalcorin","year":"2006","journal-title":"J. Mol. Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijpara.2013.09.007","article-title":"New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis","volume":"44","author":"Pfaff","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"a016600","DOI":"10.1101\/cshperspect.a016600","article-title":"Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins","volume":"7","author":"Prakash","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0166-6851(01)00284-5","article-title":"Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii","volume":"115","author":"Radke","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.4161\/cc.11.6.19446","article-title":"p97\/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response","volume":"11","author":"Ramadan","year":"2012","journal-title":"Cell Cycle"},{"key":"B90","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0959-437X(02)00282-4","article-title":"Histone H2A variants H2AX and H2AZ","volume":"12","author":"Redon","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.4161\/cc.25836","article-title":"gammaH2AX spreading linked to homology search","volume":"12","author":"Renkawitz","year":"2013","journal-title":"Cell Cycle"},{"key":"B92","doi-asserted-by":"publisher","first-page":"6423","DOI":"10.1128\/MCB.18.11.6423","article-title":"Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation","volume":"18","author":"Rijkers","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"B94","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.tibs.2014.07.003","article-title":"Holliday junction processing enzymes as guardians of genome stability","volume":"39","author":"Sarbajna","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.cell.2011.03.041","article-title":"Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11","volume":"145","author":"Schlacher","year":"2011","journal-title":"Cell"},{"key":"B96","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.mrfmmm.2013.07.007","article-title":"Double strand break repair functions of histone H2AX","volume":"750","author":"Scully","year":"2013","journal-title":"Mutat. Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.clon.2014.02.004","article-title":"DNA double-strand break repair in a cellular context","volume":"26","author":"Shibata","year":"2014","journal-title":"Clin. Oncol. (R. Coll. Radiol)."},{"key":"B98","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.chom.2015.10.014","article-title":"The ubiquitin proteome of Toxoplasma gondii reveals roles for protein ubiquitination in cell-cycle transitions","volume":"18","author":"Silmon de Monerri","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B99","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1128\/MMBR.05026-11","article-title":"How RecBCD enzyme and Chi promote DNA break repair and recombination: a molecular biologist's view","volume":"76","author":"Smith","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00203-013-0944-0","article-title":"DNA repair mechanisms and Toxoplasma gondii infection","volume":"196","author":"Smolarz","year":"2014","journal-title":"Arch. Microbiol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1083\/jcb.200709008","article-title":"Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin","volume":"181","author":"Spycher","year":"2008","journal-title":"J. Cell Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/nature01446","article-title":"MDC1 is a mediator of the mammalian DNA damage checkpoint","volume":"421","author":"Stewart","year":"2003","journal-title":"Nature"},{"key":"B103","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.molbiopara.2006.03.010","article-title":"Histone mediated gene activation in Toxoplasma gondii","volume":"148","author":"Sullivan","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"930","DOI":"10.4161\/cc.9.5.10931","article-title":"Tip60: connecting chromatin to DNA damage signaling","volume":"9","author":"Sun","year":"2010","journal-title":"Cell Cycle"},{"key":"B105","doi-asserted-by":"publisher","first-page":"8502","DOI":"10.1128\/MCB.01382-07","article-title":"DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity","volume":"27","author":"Sun","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.cub.2005.06.063","article-title":"Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation","volume":"15","author":"Sweeney","year":"2005","journal-title":"Curr. Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nsmb.2499","article-title":"Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination","volume":"20","author":"Tang","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1083\/jcb.201406100","article-title":"DNA2 drives processing and restart of reversed replication forks in human cells","volume":"208","author":"Thangavel","year":"2015","journal-title":"J. Cell Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbcan.2012.09.002","article-title":"Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors","volume":"1835","author":"Tomicic","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B111","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2471\/BLT.12.111732","article-title":"The global burden of congenital toxoplasmosis: a systematic review","volume":"91","author":"Torgerson","year":"2013","journal-title":"Bull. World Health Organ."},{"key":"B112","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1093\/nar\/gks1192","article-title":"Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics","volume":"41","author":"Trenaman","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1016\/j.febslet.2013.08.028","article-title":"\u03b3H2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs\/CHK2 pathway","volume":"587","author":"Tu","year":"2013","journal-title":"FEBS Lett."},{"key":"B114","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1093\/nar\/gkv061","article-title":"Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions","volume":"43","author":"Turinetto","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.tcb.2009.03.001","article-title":"Crosstalk between histone modifications during the DNA damage response","volume":"19","author":"van Attikum","year":"2009","journal-title":"Trends Cell Biol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"9074","DOI":"10.1093\/nar\/gku605","article-title":"The mammalian INO80 chromatin remodeling complex is required for replication stress recovery","volume":"42","author":"Vassileva","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B117","doi-asserted-by":"publisher","first-page":"11154","DOI":"10.1074\/jbc.M109.066134","article-title":"MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii","volume":"285","author":"Vonlaufen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B118","doi-asserted-by":"publisher","first-page":"e1003830","DOI":"10.1371\/journal.ppat.1003830","article-title":"Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation","volume":"10","author":"Wang","year":"2014","journal-title":"PLoS Pathog."},{"key":"B119","doi-asserted-by":"publisher","first-page":"e01155","DOI":"10.1128\/mBio.01155-15","article-title":"Novel approaches reveal that Toxoplasma gondii bradyzoites within tissue cysts are dynamic and replicating entities in vivo","volume":"6","author":"Watts","year":"2015","journal-title":"MBio"},{"key":"B120","doi-asserted-by":"publisher","first-page":"D391","DOI":"10.2741\/Weiss","article-title":"The development and biology of bradyzoites of Toxoplasma gondii","volume":"5","author":"Weiss","year":"2000","journal-title":"Front. Biosci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cell.2009.07.033","article-title":"Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair","volume":"139","author":"Williams","year":"2009","journal-title":"Cell"},{"key":"B122","doi-asserted-by":"publisher","first-page":"11200","DOI":"10.1073\/pnas.0802885105","article-title":"MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks","volume":"105","author":"Wu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B123","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.molcel.2012.09.026","article-title":"Histone H2A. Z controls a critical chromatin remodeling step required for DNA double-strand break repair","volume":"48","author":"Xu","year":"2012","journal-title":"Mol. Cell"},{"key":"B124","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.actatropica.2013.05.006","article-title":"Meta-analysis of prevention and treatment of toxoplasmic encephalitis in HIV-infected patients","volume":"127","author":"Yan","year":"2013","journal-title":"Acta Trop."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.3390\/biology2041338","article-title":"DNA damage response in plants: conserved and variable response compared to animals","volume":"2","author":"Yoshiyama","year":"2013","journal-title":"Biology (Basel)"},{"key":"B126","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.1128\/MCB.25.13.5363-5379.2005","article-title":"ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1","volume":"25","author":"You","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1158\/1541-7786.MCR-09-0123","article-title":"PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2","volume":"7","author":"Zhang","year":"2009","journal-title":"Mol. Cancer Res."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T10:25:57Z","timestamp":1600511157000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fmicb.2016.00627\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,3]]},"references-count":127,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2016.00627","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,3]]}}}