{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:49:10Z","timestamp":1792622950302,"version":"4.5.0"},"reference-count":270,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100007548","name":"Northwest A and F University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007548","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2016.01419","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T03:58:48Z","timestamp":1473220728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":87,"title":["Molecular Biology and Infection of Hepatitis E Virus"],"prefix":"10.3389","volume":"7","author":[{"given":"Yuchen","family":"Nan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.jconrel.2006.09.011","article-title":"Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents.","volume":"116","author":"Abes","year":"2006","journal-title":"J. Control. Release"},{"key":"B2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1365-2893.2006.00796.x","article-title":"T-cell epitope mapping of ORF2 and ORF3 proteins of human hepatitis E virus.","volume":"14","author":"Aggarwal","year":"2007","journal-title":"J. Viral Hepat."},{"key":"B3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1006\/viro.2000.0819","article-title":"The 3\u2032 end of hepatitis E virus (HEV) genome binds specifically to the viral RNA-dependent RNA polymerase (RdRp).","volume":"282","author":"Agrawal","year":"2001","journal-title":"Virology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"33756","DOI":"10.1074\/jbc.M505408200","article-title":"B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.","volume":"280","author":"Aguiar","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.virusres.2011.02.011","article-title":"Molecular virology of hepatitis E virus.","volume":"161","author":"Ahmad","year":"2011","journal-title":"Virus Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0022-2836(03)00473-X","article-title":"The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A.","volume":"330","author":"Allen","year":"2003","journal-title":"J. Mol. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1021\/bc070060v","article-title":"Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.","volume":"18","author":"Amantana","year":"2007","journal-title":"Bioconjug. Chem."},{"issue":"25133","key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/srep25133","article-title":"Identification of critical residues in hepatitis E virus macro domain involved in its interaction with viral methyltransferase and ORF3 proteins.","volume":"6","author":"Anang","year":"2016","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S1097-2765(03)00100-X","article-title":"The histone variant macroH2A interferes with transcription factor binding and SWI\/SNF nucleosome remodeling.","volume":"11","author":"Angelov","year":"2003","journal-title":"Mol. Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/(SICI)1096-9071(200003)60:3%3C275::AID-JMV5%3E3.0.CO;2-9","article-title":"Cloning, sequencing, and expression of the hepatitis E virus (HEV) nonstructural open reading frame 1 (ORF1).","volume":"60","author":"Ansari","year":"2000","journal-title":"J. Med. Virol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1089\/hgtb.2012.117","article-title":"Exon skipping quantification by quantitative reverse-transcription polymerase chain reaction in Duchenne muscular dystrophy patients treated with the antisense oligomer eteplirsen.","volume":"23","author":"Anthony","year":"2012","journal-title":"Hum. Gene. Ther. Methods"},{"key":"B12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1159\/000149370","article-title":"Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route.","volume":"20","author":"Balayan","year":"1983","journal-title":"Intervirology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.virusres.2011.03.019","article-title":"A novel member of the family Hepeviridae from cutthroat trout (Oncorhynchus clarkii).","volume":"158","author":"Batts","year":"2011","journal-title":"Virus Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0022-1759(98)00168-9","article-title":"Indirect immobilization of recombinant proteins to a solid phase using the albumin binding domain of streptococcal protein G and immobilized albumin.","volume":"221","author":"Baumann","year":"1998","journal-title":"J. Immunol. Methods"},{"key":"B15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.meegid.2015.06.026","article-title":"Antigenic composition and immunoreactivity differences between HEV recombinant capsid proteins generated from different genotypes.","volume":"34","author":"Behloul","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s007050070099","article-title":"Reclassification of the Caliciviridae into distinct genera and exclusion of hepatitis E virus from the family on the basis of comparative phylogenetic analysis.","volume":"145","author":"Berke","year":"2000","journal-title":"Arch. Virol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1099\/vir.0.063602-0","article-title":"Evidence of extrahepatic replication of hepatitis E virus in human placenta.","volume":"95","author":"Bose","year":"2014","journal-title":"J. Gen. Virol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.1128\/JVI.02360-06","article-title":"Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models.","volume":"81","author":"Burrer","year":"2007","journal-title":"J. Virol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"13040","DOI":"10.1128\/JVI.01475-10","article-title":"The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication.","volume":"84","author":"Cao","year":"2010","journal-title":"J. Virol."},{"issue":"e17","key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2012.7","article-title":"Molecular biology and replication of hepatitis E virus.","volume":"1","author":"Cao","year":"2012","journal-title":"Emerg. Microbes Infect."},{"key":"B21","author":"CDC","year":"2016","journal-title":"HEV Laboratory Testing Requests [Online]."},{"issue":"e22412","key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022412","article-title":"The hepatitis E virus ORF3 protein regulates the expression of liver-specific genes by modulating localization of hepatocyte nuclear factor 4.","volume":"6","author":"Chandra","year":"2011","journal-title":"PLoS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1128\/JVI.01994-09","article-title":"The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex.","volume":"84","author":"Chandra","year":"2010","journal-title":"J. Virol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"7100","DOI":"10.1128\/JVI.00403-08","article-title":"The hepatitis E virus ORF3 protein modulates epidermal growth factor receptor trafficking, STAT3 translocation, and the acute-phase response.","volume":"82","author":"Chandra","year":"2008","journal-title":"J. Virol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000478","article-title":"HEV-1 harbouring HEV-4 nonstructural protein (ORF1) replicates in transfected porcine kidney cells.","author":"Chatterjee","year":"2016","journal-title":"J. Gen. Virol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/hep.22933","article-title":"Chromodomain helicase\/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival.","volume":"50","author":"Chen","year":"2009","journal-title":"Hepatology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1086\/591970","article-title":"Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark.","volume":"47","author":"Christensen","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"13124","DOI":"10.1128\/JVI.02414-12","article-title":"Complete genome sequence of hepatitis E virus from rabbits in the United States.","volume":"86","author":"Cossaboom","year":"2012","journal-title":"J. Virol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/31275","article-title":"Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals.","volume":"393","author":"Costanzi","year":"1998","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/S1473-3099(08)70255-X","article-title":"Hepatitis E: an emerging infection in developed countries.","volume":"8","author":"Dalton","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrneurol.2015.234","article-title":"Hepatitis E virus and neurological injury.","volume":"12","author":"Dalton","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1128\/AAC.01795-13","article-title":"Ribavirin inhibits in vitro hepatitis E virus replication through depletion of cellular GTP pools and is moderately synergistic with alpha interferon.","volume":"58","author":"Debing","year":"2014a","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1008","key":"B33","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1053\/j.gastro.2014.08.040","article-title":"A mutation in the hepatitis E virus RNA polymerase promotes its replication and associates with ribavirin treatment failure in organ transplant recipients.","volume":"147","author":"Debing","year":"2014b","journal-title":"Gastroenterology"},{"key":"B34","first-page":"102","article-title":"[Analysis of the organization of immunodominant epitopes of hepatitis virus E orf2 and orf3 proteins using synthetic peptides].","volume":"42","author":"Dement\u2019eva","year":"1997","journal-title":"Vopr. Virusol."},{"issue":"26827","key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/srep26827","article-title":"Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies.","volume":"6","author":"Devhare","year":"2016","journal-title":"Sci. Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1002\/hep.25530","article-title":"Suppression of interferon-alpha signaling by hepatitis E virus.","volume":"55","author":"Dong","year":"2012","journal-title":"Hepatology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1021\/pr060171o","article-title":"Disorder and sequence repeats in hub proteins and their implications for network evolution.","volume":"5","author":"Dosztanyi","year":"2006","journal-title":"J. Proteome Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/jvh.12515","article-title":"Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells.","volume":"23","author":"Drave","year":"2016","journal-title":"J. Viral. Hepat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"9134","DOI":"10.1128\/JVI.00800-12","article-title":"Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae.","volume":"86","author":"Drexler","year":"2012","journal-title":"J. Virol."},{"issue":"e24","key":"B40","doi-asserted-by":"publisher","DOI":"10.1086\/654801","article-title":"Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances.","volume":"51","author":"Drobeniuc","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"S1","key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-S2-S1","article-title":"The unfoldomics decade: an update on intrinsically disordered proteins.","volume":"9(Suppl. 2)","author":"Dunker","year":"2008","journal-title":"BMC Genomics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"8493","DOI":"10.1128\/JVI.00713-06","article-title":"Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.","volume":"80","author":"Egloff","year":"2006","journal-title":"J. Virol."},{"issue":"4838","key":"B43","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.9.4838-4846.2004","article-title":"In vitro replication of hepatitis E virus (HEV) genomes and of an HEV replicon expressing green fluorescent protein.","volume":"78","author":"Emerson","year":"2004","journal-title":"J. Virol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"10457","DOI":"10.1128\/JVI.00892-06","article-title":"ORF3 protein of hepatitis E virus is not required for replication, virion assembly, or infection of hepatoma cells in vitro.","volume":"80","author":"Emerson","year":"2006","journal-title":"J. Virol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"9059","DOI":"10.1128\/JVI.00593-10","article-title":"Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif.","volume":"84","author":"Emerson","year":"2010","journal-title":"J. Virol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/rmv.384","article-title":"Hepatitis E virus.","volume":"13","author":"Emerson","year":"2003","journal-title":"Rev. Med. Virol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"15270","DOI":"10.1073\/pnas.251555098","article-title":"Recombinant hepatitis E virus genomes infectious for primates: importance of capping and discovery of a cis-reactive element.","volume":"98","author":"Emerson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B48","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1099\/0022-1317-80-3-681","article-title":"A hepatitis E virus variant from the United States: molecular characterization and transmission in cynomolgus macaques.","volume":"80 (Pt. 3)","author":"Erker","year":"1999","journal-title":"J. Gen. Virol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1146\/annurev-virology-031413-085359","article-title":"Naked viruses that aren\u2019t always naked: quasi-enveloped agents of acute hepatitis.","volume":"1","author":"Feng","year":"2014","journal-title":"Annu. Rev. Virol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jhep.2015.08.034","article-title":"Detection and assessment of infectivity of hepatitis E virus in urine.","volume":"64","author":"Geng","year":"2016","journal-title":"J. Hepatol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.meegid.2010.12.012","article-title":"The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China.","volume":"11","author":"Geng","year":"2011","journal-title":"Infect. Genet. Evol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jcv.2011.06.004","article-title":"Treatment of severe acute hepatitis E by ribavirin.","volume":"52","author":"Gerolami","year":"2011","journal-title":"J. Clin. Virol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0014-5793(91)81034-6","article-title":"Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses.","volume":"288","author":"Gorbalenya","year":"1991","journal-title":"FEBS Lett."},{"key":"B54","doi-asserted-by":"publisher","first-page":"6680","DOI":"10.1128\/JVI.79.11.6680-6689.2005","article-title":"The open reading frame 3 gene of hepatitis E virus contains a cis-reactive element and encodes a protein required for infection of macaques.","volume":"79","author":"Graff","year":"2005","journal-title":"J. Virol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"5919","DOI":"10.1128\/JVI.00046-06","article-title":"A bicistronic subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus.","volume":"80","author":"Graff","year":"2006","journal-title":"J. Virol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1128\/JVI.01219-07","article-title":"Mutations within potential glycosylation sites in the capsid protein of hepatitis E virus prevent the formation of infectious virus particles.","volume":"82","author":"Graff","year":"2008","journal-title":"J. Virol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/hep.26636","article-title":"Chronic hepatitis E in an immunocompetent patient: a case report.","volume":"59","author":"Grewal","year":"2014","journal-title":"Hepatology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/cr.2015.34","article-title":"Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody.","volume":"25","author":"Gu","year":"2015","journal-title":"Cell Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"12992","DOI":"10.1073\/pnas.0904848106","article-title":"Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding.","volume":"106","author":"Guu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1099\/0022-1317-83-9-2201","article-title":"The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and chicken big liver and spleen disease virus.","volume":"83","author":"Haqshenas","year":"2002","journal-title":"J. Gen. Virol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1099\/0022-1317-82-10-2449","article-title":"Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States.","volume":"82","author":"Haqshenas","year":"2001","journal-title":"J. Gen. Virol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1099\/vir.0.83308-0","article-title":"Putative receptor-binding sites of hepatitis E virus.","volume":"89","author":"He","year":"2008","journal-title":"J. Gen. Virol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jhep.2015.11.013","article-title":"Stem cell-derived hepatocytes: a novel model for hepatitis E virus replication.","volume":"64","author":"Helsen","year":"2016","journal-title":"J. Hepatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1128\/CVI.00231-06","article-title":"Use of serological assays for diagnosis of hepatitis E virus genotype 1 and 3 infections in a setting of low endemicity.","volume":"14","author":"Herremans","year":"2007","journal-title":"Clin. Vaccine Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/tra.12260","article-title":"Hepatitis E virus enters liver cells through a dynamin-2, clathrin and membrane cholesterol-dependent pathway.","volume":"16","author":"Holla","year":"2015","journal-title":"Traffic"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1055\/s-0033-1338110","article-title":"Molecular virology of hepatitis E virus.","volume":"33","author":"Holla","year":"2013","journal-title":"Semin. Liver Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1056\/NEJMra1204512","article-title":"Hepatitis E.","volume":"367","author":"Hoofnagle","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.antiviral.2009.06.008","article-title":"Effective inhibition of hepatitis E virus replication in A549 cells and piglets by RNA interference (RNAi) targeting RNA-dependent RNA polymerase.","volume":"83","author":"Huang","year":"2009","journal-title":"Antiviral Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1099\/vir.0.79841-0","article-title":"Determination and analysis of the complete genomic sequence of avian hepatitis E virus (avian HEV) and attempts to infect rhesus monkeys with avian HEV.","volume":"85","author":"Huang","year":"2004","journal-title":"J. Gen. Virol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/jmv.1890470402","article-title":"Hepatitis E virus (87A strain) propagated in A549 cells.","volume":"47","author":"Huang","year":"1995","journal-title":"J. Med. Virol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1128\/JVI.02259-06","article-title":"Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo.","volume":"81","author":"Huang","year":"2007","journal-title":"J. Virol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3109\/10409238.2010.502516","article-title":"The ESCRT complexes.","volume":"45","author":"Hurley","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/jmv.23827","article-title":"Serological cross reactivity to CMV and EBV causes problems in the diagnosis of acute hepatitis E virus infection.","volume":"86","author":"Hyams","year":"2014","journal-title":"J. Med. Virol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s00705-009-0538-y","article-title":"Determination of the 5\u2032-terminal sequence of subgenomic RNA of hepatitis E virus strains in cultured cells.","volume":"154","author":"Ichiyama","year":"2009","journal-title":"Arch. Virol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/s1462399499001271","article-title":"Molecular biology and pathogenesis of hepatitis E virus.","volume":"1999","author":"Jameel","year":"1999","journal-title":"Expert Rev. Mol. Med."},{"key":"B76","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/jvi.70.1.207-216.1996","article-title":"Expression in animal cells and characterization of the hepatitis E virus structural proteins.","volume":"70","author":"Jameel","year":"1996","journal-title":"J. Virol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.virusres.2012.09.015","article-title":"Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC\/PRF\/5 cells.","volume":"170","author":"Jirintai","year":"2012","journal-title":"Virus Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.virusres.2014.03.002","article-title":"Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines.","volume":"185","author":"Jirintai","year":"2014","journal-title":"Virus Res."},{"issue":"e25378","key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025378","article-title":"Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins.","volume":"6","author":"John","year":"2011","journal-title":"PLoS ONE"},{"key":"B80","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1099\/vir.0.016584-0","article-title":"Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR.","volume":"91","author":"Johne","year":"2010","journal-title":"J. Gen. Virol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1099\/0022-1317-82-7-1687","article-title":"Acute hepatitis caused by a novel strain of hepatitis E virus most closely related to United States strains.","volume":"82","author":"Kabrane-Lazizi","year":"2001","journal-title":"J. Gen. Virol."},{"key":"B82","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1128\/jvi.71.4.2583-2590.1997","article-title":"Virus-encoded RNA helicases.","volume":"71","author":"Kadare","year":"1997","journal-title":"J. Virol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"12714","DOI":"10.1128\/JVI.00717-09","article-title":"Heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection.","volume":"83","author":"Kalia","year":"2009","journal-title":"J. Virol."},{"issue":"20","key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2014.07.005","article-title":"Hepatitis E virus: chronic infection, extra-hepatic manifestations, and treatment.","volume":"39","author":"Kamar","year":"2014","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1016\/S0140-6736(11)61849-7","article-title":"Hepatitis E.","volume":"379","author":"Kamar","year":"2012a","journal-title":"Lancet"},{"key":"B86","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3201\/eid1702.100856","article-title":"Hepatitis E virus and neurologic disorders.","volume":"17","author":"Kamar","year":"2011","journal-title":"Emerg. Infect. Dis."},{"issue":"60","key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26927","article-title":"Does chronic hepatitis E virus infection exist in immunocompetent patients? Hepatology","author":"Kamar","year":"2014"},{"key":"B88","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1053\/j.ajkd.2004.09.006","article-title":"Acute hepatitis and renal function impairment related to infection by hepatitis E virus in a renal allograft recipient.","volume":"45","author":"Kamar","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1053\/j.gastro.2010.08.002","article-title":"Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection.","volume":"139","author":"Kamar","year":"2010","journal-title":"Gastroenterology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1097\/TP.0b013e318245f14c","article-title":"Hepatitis E virus and the kidney in solid-organ transplant patients.","volume":"93","author":"Kamar","year":"2012b","journal-title":"Transplantation"},{"key":"B91","doi-asserted-by":"publisher","first-page":"6375","DOI":"10.1128\/JVI.02571-08","article-title":"The hepatitis E virus open reading frame 3 product interacts with microtubules and interferes with their dynamics.","volume":"83","author":"Kannan","year":"2009","journal-title":"J. Virol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/j.1365-2893.2011.01559.x","article-title":"Hepatitis E virus enters liver cells through receptor-dependent clathrin-mediated endocytosis.","volume":"19","author":"Kapur","year":"2012","journal-title":"J. Viral. Hepat."},{"key":"B93","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1128\/JVI.02130-09","article-title":"NTPase and 5\u2032 to 3\u2032 RNA duplex-unwinding activities of the hepatitis E virus helicase domain.","volume":"84","author":"Karpe","year":"2010a","journal-title":"J. Virol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"9637","DOI":"10.1128\/JVI.00492-10","article-title":"RNA 5\u2032-triphosphatase activity of the hepatitis E virus helicase domain.","volume":"84","author":"Karpe","year":"2010b","journal-title":"J. Virol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1099\/vir.0.033738-0","article-title":"Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease.","volume":"92","author":"Karpe","year":"2011","journal-title":"J. Gen. Virol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"28345","DOI":"10.1074\/jbc.M400457200","article-title":"The hepatitis E virus open reading frame 3 protein activates ERK through binding and inhibition of the MAPK phosphatase.","volume":"279","author":"Kar-Roy","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"e0124396","key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124396","article-title":"Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17.","volume":"10","author":"Kenney","year":"2015a","journal-title":"PLoS ONE"},{"key":"B98","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1128\/JVI.03582-14","article-title":"The lysine residues within the human ribosomal protein S17 sequence naturally inserted into the viral nonstructural protein of a unique strain of hepatitis E virus are important for enhanced virus replication.","volume":"89","author":"Kenney","year":"2015b","journal-title":"J. Virol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.1128\/JVI.06711-11","article-title":"The PSAP motif within the ORF3 protein of an avian strain of the hepatitis E virus is not critical for viral infectivity in vivo but plays a role in virus release.","volume":"86","author":"Kenney","year":"2012","journal-title":"J. Virol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.virol.2015.09.012","article-title":"Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101.","volume":"486","author":"Kenney","year":"2015","journal-title":"Virology"},{"key":"B101","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.1128\/JCM.42.8.3883-3885.2004","article-title":"Infection of a Japanese patient by genotype 4 hepatitis e virus while traveling in Vietnam.","volume":"42","author":"Koizumi","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1099\/0022-1317-72-9-2197","article-title":"The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses.","volume":"72 (Pt. 9)","author":"Koonin","year":"1991","journal-title":"J. Gen. Virol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3109\/10409239309078440","article-title":"Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences.","volume":"28","author":"Koonin","year":"1993","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"8259","DOI":"10.1073\/pnas.89.17.8259","article-title":"Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.","volume":"89","author":"Koonin","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B105","doi-asserted-by":"publisher","first-page":"42389","DOI":"10.1074\/jbc.M101546200","article-title":"The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.","volume":"276","author":"Korkaya","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"365","DOI":"10.4269\/ajtmh.13-0265","article-title":"Fetal and neonatal health consequences of vertically transmitted hepatitis E virus infection.","volume":"90","author":"Krain","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.3201\/eid1912.130614","article-title":"Hepatitis E virus variant in farmed mink, Denmark.","volume":"19","author":"Krog","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"B108","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cyto.2013.09.022","article-title":"Association of cytokines in hepatitis E with pregnancy outcome.","volume":"65","author":"Kumar","year":"2014","journal-title":"Cytokine"},{"key":"B109","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.antiviral.2010.01.005","article-title":"Inhibition of Hepatitis E virus replication using short hairpin RNA (shRNA).","volume":"85","author":"Kumar","year":"2010","journal-title":"Antiviral Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.4065\/72.12.1133","article-title":"Acute hepatitis E by a new isolate acquired in the United States.","volume":"72","author":"Kwo","year":"1997","journal-title":"Mayo Clin. Proc."},{"key":"B111","doi-asserted-by":"publisher","first-page":"25711","DOI":"10.3390\/ijms161025711","article-title":"Epidemiology of Hepatitis E virus in European Countries.","volume":"16","author":"Lapa","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/infdis\/jit438","article-title":"Influence of polyproline region and macro domain genetic heterogeneity on HEV persistence in immunocompromised patients.","volume":"209","author":"Lhomme","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1128\/AAC.02496-15","article-title":"Mutation in the Hepatitis E virus polymerase and outcome of ribavirin therapy.","volume":"60","author":"Lhomme","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00705-16","article-title":"Viral macro domains reverse protein ADP-ribosylation.","volume":"[Epub ahead of print]","author":"Li","year":"2016","journal-title":"J. Virol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1099\/vir.0.025205-0","article-title":"The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation.","volume":"91","author":"Li","year":"2010","journal-title":"J. Gen. Virol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.1074\/jbc.M410361200","article-title":"Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid.","volume":"280","author":"Li","year":"2005a","journal-title":"J. Biol. Chem."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1016\/j.vaccine.2004.11.064","article-title":"A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates.","volume":"23","author":"Li","year":"2005b","journal-title":"Vaccine"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.3201\/eid1112.051041","article-title":"Hepatitis E virus transmission from wild boar meat.","volume":"11","author":"Li","year":"2005c","journal-title":"Emerg. Infect. Dis."},{"key":"B119","doi-asserted-by":"publisher","first-page":"12999","DOI":"10.1128\/JVI.79.20.12999-13006.2005","article-title":"Essential elements of the capsid protein for self-assembly into empty virus-like particles of hepatitis E virus.","volume":"79","author":"Li","year":"2005d","journal-title":"J. Virol."},{"key":"B120","doi-asserted-by":"crossref","first-page":"7207","DOI":"10.1128\/jvi.71.10.7207-7213.1997","article-title":"Expression and self-assembly of empty virus-like particles of hepatitis E virus.","volume":"71","author":"Li","year":"1997","journal-title":"J. Virol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"5412","DOI":"10.1128\/JVI.74.12.5412-5423.2000","article-title":"Rubella virus nonstructural protein protease domains involved in trans- and cis-cleavage activities.","volume":"74","author":"Liang","year":"2000","journal-title":"J. Virol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1099\/vir.0.059238-0","article-title":"Novel hepatitis E like virus found in Swedish moose.","volume":"95","author":"Lin","year":"2014","journal-title":"J. Gen. Virol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1128\/JVI.01897-08","article-title":"A novel mycovirus that is related to the human pathogen hepatitis E virus and rubi-like viruses.","volume":"83","author":"Liu","year":"2009","journal-title":"J. Virol."},{"issue":"e87600","key":"B124","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087600","article-title":"Management of hepatitis E virus (HEV) zoonotic transmission: protection of rabbits against HEV challenge following immunization with HEV 239 vaccine.","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS ONE"},{"key":"B125","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.cytogfr.2013.07.002","article-title":"Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins.","volume":"24","author":"Liu","year":"2013","journal-title":"Cytokine Growth Factor Rev."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1002\/jmv.20905","article-title":"Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia.","volume":"79","author":"Lorenzo","year":"2007","journal-title":"J. Med. Virol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/rmv.482","article-title":"Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis.","volume":"16","author":"Lu","year":"2006","journal-title":"Rev. Med. Virol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.1128\/JVI.75.14.6249-6255.2001","article-title":"Virus-specific mRNA capping enzyme encoded by hepatitis E virus.","volume":"75","author":"Magden","year":"2001","journal-title":"J. Virol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jcv.2015.09.011","article-title":"Role of TLR gene expression and cytokine profiling in the immunopathogenesis of viral hepatitis E.","volume":"73","author":"Majumdar","year":"2015","journal-title":"J. Clin. Virol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"85","DOI":"10.7326\/0003-4819-153-2-201007200-00257","article-title":"Brief communication: case reports of ribavirin treatment for chronic hepatitis E.","volume":"153","author":"Mallet","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"B131","doi-asserted-by":"publisher","first-page":"9470","DOI":"10.1074\/jbc.M109.071043","article-title":"Virus-triggered ubiquitination of TRAF3\/6 by cIAP1\/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.","volume":"285","author":"Mao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B132","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1006\/viro.1994.1070","article-title":"Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing.","volume":"198","author":"Marr","year":"1994","journal-title":"Virology"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1126\/science.286.5442.1153","article-title":"A biochemical genomics approach for identifying genes by the activity of their products.","volume":"286","author":"Martzen","year":"1999","journal-title":"Science"},{"key":"B134","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/hep.510270331","article-title":"Evaluation of assays for antibody to hepatitis E virus by a serum panel. Hepatitis E virus antibody serum panel evaluation group.","volume":"27","author":"Mast","year":"1998","journal-title":"Hepatology"},{"key":"B135","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1006\/prep.1996.0099","article-title":"Purification of a soluble hepatitis E open reading frame 2-derived protein with unique antigenic properties.","volume":"8","author":"McAtee","year":"1996","journal-title":"Protein Expr. Purif."},{"key":"B136","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/ana.23982","article-title":"Eteplirsen for the treatment of Duchenne muscular dystrophy.","volume":"74","author":"Mendell","year":"2013","journal-title":"Ann. Neurol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1006\/viro.2001.1093","article-title":"Identification and characterization of the neutralization epitope(s) of the hepatitis E virus.","volume":"288","author":"Meng","year":"2001","journal-title":"Virology"},{"key":"B138","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1365-2893.2009.01257.x","article-title":"Recent advances in Hepatitis E virus.","volume":"17","author":"Meng","year":"2010","journal-title":"J. Viral. Hepat."},{"key":"B139","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1055\/s-0033-1338113","article-title":"Zoonotic and foodborne transmission of hepatitis E virus.","volume":"33","author":"Meng","year":"2013","journal-title":"Semin. Liver Dis."},{"key":"B140","doi-asserted-by":"publisher","first-page":"9860","DOI":"10.1073\/pnas.94.18.9860","article-title":"A novel virus in swine is closely related to the human hepatitis E virus.","volume":"94","author":"Meng","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B141","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.virusres.2013.11.022","article-title":"Mutagenesis of hepatitis E virus helicase motifs: effects on enzyme activity.","volume":"179","author":"Mhaindarkar","year":"2014","journal-title":"Virus Res."},{"key":"B142","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3201\/eid2001.130600","article-title":"Hepatitis E virus genotype 4, Denmark, 2012.","volume":"20","author":"Midgley","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"B143","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1128\/JCM.40.9.3209-3218.2002","article-title":"Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan.","volume":"40","author":"Mizuo","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1111\/j.1462-5822.2009.01340.x","article-title":"The hepatitis E virus ORF3 protein stabilizes HIF-1alpha and enhances HIF-1-mediated transcriptional activity through p300\/CBP.","volume":"11","author":"Moin","year":"2009","journal-title":"Cell Microbiol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"21124","DOI":"10.1074\/jbc.M701696200","article-title":"The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death.","volume":"282","author":"Moin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B146","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.virusres.2011.03.015","article-title":"Structure of hepatitis E viral particle.","volume":"161","author":"Mori","year":"2011","journal-title":"Virus Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.2174\/1381612811319160010","article-title":"In vivo delivery of morpholino oligos by cell-penetrating peptides.","volume":"19","author":"Moulton","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"B148","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s00705-013-1912-3","article-title":"The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.","volume":"159","author":"Nagashima","year":"2014","journal-title":"Arch. Virol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1099\/vir.0.035378-0","article-title":"Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions.","volume":"92(Pt. 12)","author":"Nagashima","year":"2011a","journal-title":"J. Gen. Virol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1099\/vir.0.025791-0","article-title":"A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells.","volume":"92","author":"Nagashima","year":"2011b","journal-title":"J. Gen. Virol."},{"issue":"e1005521","key":"B151","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005521","article-title":"Endoplasmic reticulum stress induced synthesis of a novel viral factor mediates efficient replication of genotype-1 hepatitis E virus.","volume":"12","author":"Nair","year":"2016","journal-title":"PLoS Pathog."},{"key":"B152","author":"Nan","year":"2014","journal-title":"Interferense of Host Innate Immune Response by Hepatitis E Virus."},{"key":"B153","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.antiviral.2015.06.006","article-title":"Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers.","volume":"120","author":"Nan","year":"2015","journal-title":"Antiviral Res."},{"key":"B154","doi-asserted-by":"publisher","first-page":"8696","DOI":"10.1128\/JVI.01228-14","article-title":"Enhancement of interferon induction by ORF3 product of hepatitis E virus.","volume":"88","author":"Nan","year":"2014a","journal-title":"J. Virol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"11924","DOI":"10.1128\/JVI.01935-14","article-title":"Hepatitis E virus inhibits type I interferon induction by ORF1 products.","volume":"88","author":"Nan","year":"2014b","journal-title":"J. Virol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jmb.2008.10.045","article-title":"Differential activities of cellular and viral macro domain proteins in binding of ADP-ribose metabolites.","volume":"385","author":"Neuvonen","year":"2009","journal-title":"J. Mol. Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11010-016-2715-0","article-title":"Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion.","volume":"417","author":"Ojha","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"B158","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.virusres.2007.02.002","article-title":"Genetic variability and evolution of hepatitis E virus.","volume":"127","author":"Okamoto","year":"2007","journal-title":"Virus Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/rmv.678","article-title":"Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood.","volume":"21","author":"Okamoto","year":"2011","journal-title":"Rev. Med. Virol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00535-012-0682-0","article-title":"Culture systems for hepatitis E virus.","volume":"48","author":"Okamoto","year":"2013","journal-title":"J. Gastroenterol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1006\/viro.1998.9463","article-title":"Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.","volume":"252","author":"O\u2019Reilly","year":"1998","journal-title":"Virology"},{"issue":"13872","key":"B162","doi-asserted-by":"publisher","DOI":"10.1038\/srep13872","article-title":"The hepatitis E virus intraviral interactome.","volume":"5","author":"Osterman","year":"2015","journal-title":"Sci. Rep."},{"key":"B163","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.virol.2008.03.032","article-title":"Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers.","volume":"376","author":"Paessler","year":"2008","journal-title":"Virology"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1099\/vir.0.066142-0","article-title":"Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein.","volume":"95(Pt. 8)","author":"Paliwal","year":"2014","journal-title":"J. Gen. Virol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1128\/JVI.74.5.2430-2437.2000","article-title":"The in vitro-synthesized RNA from a cDNA clone of hepatitis E virus is infectious.","volume":"74","author":"Panda","year":"2000","journal-title":"J. Virol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.virusres.2013.07.020","article-title":"Molecular characterization of hepatitis E virus ORF1 gene supports a papain-like cysteine protease (PCP)-domain activity.","volume":"178","author":"Parvez","year":"2013","journal-title":"Virus Res."},{"key":"B167","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.gene.2015.04.026","article-title":"The hepatitis E virus ORF1 \u2018X-domain\u2019 residues form a putative macrodomain protein\/Appr-1-pase catalytic-site, critical for viral RNA replication.","volume":"566","author":"Parvez","year":"2015a","journal-title":"Gene"},{"key":"B168","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.gene.2015.01.033","article-title":"The intergenic-junction variant (genotype 2 isolate) of hepatitis E virus restores the CREX \u2018stem-loop\u2019 structural integrity, essential for viral life cycle.","volume":"559","author":"Parvez","year":"2015b","journal-title":"Gene"},{"key":"B169","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s10616-014-9785-1","article-title":"Evidence of MAPK-JNK1\/2 activation by hepatitis E virus ORF3 protein in cultured hepatoma cells.","volume":"67","author":"Parvez","year":"2015","journal-title":"Cytotechnology"},{"key":"B170","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3201\/eid1805.111712","article-title":"Hepatitis E virus infection among solid organ transplant recipients, the Netherlands.","volume":"18","author":"Pas","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"B171","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1128\/JVI.02676-12","article-title":"Herpesvirus tegument protein pUL37 interacts with dystonin\/BPAG1 to promote capsid transport on microtubules during egress.","volume":"87","author":"Pasdeloup","year":"2013","journal-title":"J. Virol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.coviro.2014.12.006","article-title":"Zoonotic origin of hepatitis E.","volume":"10","author":"Pavio","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1126\/science.1529340","article-title":"MacroH2A, a core histone containing a large nonhistone region.","volume":"257","author":"Pehrson","year":"1992","journal-title":"Science"},{"key":"B174","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1093\/nar\/26.12.2837","article-title":"Evolutionary conservation of histone macroH2A subtypes and domains.","volume":"26","author":"Pehrson","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0960-9822(00)00832-0","article-title":"Higher concentrations of histone macroH2A in the Barr body are correlated with higher nucleosome density.","volume":"10","author":"Perche","year":"2000","journal-title":"Curr. Biol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1099\/vir.0.049577-0","article-title":"Early secretory pathway localization and lack of processing for hepatitis E virus replication protein pORF1.","volume":"94","author":"Perttila","year":"2013","journal-title":"J. Gen. Virol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1128\/JVI.01854-08","article-title":"Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo.","volume":"83","author":"Pudupakam","year":"2009","journal-title":"J. Virol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"10031","DOI":"10.1128\/JVI.00763-11","article-title":"Mutational analysis of the hypervariable region of hepatitis e virus reveals its involvement in the efficiency of viral RNA replication.","volume":"85","author":"Pudupakam","year":"2011","journal-title":"J. Virol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.jhep.2007.12.008","article-title":"Hepatitis E: an emerging awareness of an old disease.","volume":"48","author":"Purcell","year":"2008","journal-title":"J. Hepatol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"10186","DOI":"10.1128\/JVI.01374-12","article-title":"Evolution of the hepatitis E virus polyproline region: order from disorder.","volume":"86","author":"Purdy","year":"2012","journal-title":"J. Virol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.virusres.2011.04.030","article-title":"The molecular epidemiology of hepatitis E virus infection.","volume":"161","author":"Purdy","year":"2011","journal-title":"Virus Res."},{"issue":"e35974","key":"B182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035974","article-title":"The hepatitis E virus polyproline region is involved in viral adaptation.","volume":"7","author":"Purdy","year":"2012","journal-title":"PLoS ONE"},{"key":"B183","doi-asserted-by":"publisher","first-page":"12721","DOI":"10.1128\/JVI.79.20.12721-12731.2005","article-title":"ADP-ribose-1\u201d-monophosphatase: a conserved coronavirus enzyme that is dispensable for viral replication in tissue culture.","volume":"79","author":"Putics","year":"2005","journal-title":"J. Virol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1099\/vir.0.81596-0","article-title":"Identification of protease and ADP-ribose 1\u201d-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3.","volume":"87","author":"Putics","year":"2006","journal-title":"J. Gen. Virol."},{"issue":"e0132503","key":"B185","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132503","article-title":"Hepatitis E virus produced from cell culture has a lipid envelope.","volume":"10","author":"Qi","year":"2015","journal-title":"PLoS ONE"},{"key":"B186","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S0923-2508(99)80001-1","article-title":"A secreted streptococcal cysteine protease can cleave a surface-expressed M1 protein and alter the immunoglobulin binding properties.","volume":"149","author":"Raeder","year":"1998","journal-title":"Res. Microbiol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.3201\/eid1808.111659","article-title":"Novel hepatitis E virus in ferrets, the Netherlands.","volume":"18","author":"Raj","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"B188","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1021\/bi7016552","article-title":"The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II.","volume":"47","author":"Ratra","year":"2008","journal-title":"Biochemistry"},{"key":"B189","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1099\/vir.0.009274-0","article-title":"ORF3 protein of hepatitis E virus interacts with the Bbeta chain of fibrinogen resulting in decreased fibrinogen secretion from HuH-7 cells.","volume":"90","author":"Ratra","year":"2009","journal-title":"J. Gen. Virol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.virol.2007.07.036","article-title":"Subcellular localization of hepatitis E virus (HEV) replicase.","volume":"370","author":"Rehman","year":"2008","journal-title":"Virology"},{"key":"B191","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-7091-9300-6_2","article-title":"Molecular organization and replication of hepatitis E virus (HEV).","volume":"7","author":"Reyes","year":"1993","journal-title":"Arch. Virol. Suppl."},{"key":"B192","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1126\/science.2107574","article-title":"Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis.","volume":"247","author":"Reyes","year":"1990","journal-title":"Science"},{"key":"B193","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1006\/prep.1997.0817","article-title":"Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells.","volume":"12","author":"Robinson","year":"1998","journal-title":"Protein Expr. Purif."},{"key":"B194","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1099\/vir.0.049858-0","article-title":"New models of hepatitis E virus replication in human and porcine hepatocyte cell lines.","volume":"94","author":"Rogee","year":"2013","journal-title":"J. Gen. Virol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1007\/s007050070093","article-title":"Expression of the hepatitis E virus ORF1.","volume":"145","author":"Ropp","year":"2000","journal-title":"Arch. Virol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1099\/0022-1317-73-8-2129","article-title":"Conservation of the putative methyltransferase domain: a hallmark of the \u2018Sindbis-like\u2019 supergroup of positive-strand RNA viruses.","volume":"73 (Pt 8)","author":"Rozanov","year":"1992","journal-title":"J. Gen. Virol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/jmv.20564","article-title":"UK acquired hepatitis E\u2013An emerging problem?","volume":"78","author":"Sadler","year":"2006","journal-title":"J. Med. Virol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/j.str.2005.07.022","article-title":"Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1\u201d-phosphate dephosphorylation by a conserved domain of nsP3.","volume":"13","author":"Saikatendu","year":"2005","journal-title":"Structure"},{"key":"B199","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.1016\/j.vaccine.2012.08.013","article-title":"Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs.","volume":"30","author":"Sanford","year":"2012","journal-title":"Vaccine"},{"key":"B200","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/hep.27990","article-title":"Is hepatitis E virus an emerging problem in industrialized countries?","volume":"62","author":"Sayed","year":"2015","journal-title":"Hepatology"},{"key":"B201","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/(SICI)1096-9071(199903)57:3243::AID-JMV63.0.CO;2-R","article-title":"Novel hepatitis E virus (HEV) isolates from Europe: evidence for additional genotypes of HEV.","volume":"57","author":"Schlauder","year":"1999","journal-title":"J. Med. Virol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"5548","DOI":"10.1128\/JVI.74.12.5548-5555.2000","article-title":"Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein.","volume":"74","author":"Schofield","year":"2000","journal-title":"J. Virol."},{"issue":"38","key":"B203","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-3-38","article-title":"Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein.","volume":"3","author":"Sehgal","year":"2006","journal-title":"Virol. J."},{"key":"B204","first-page":"156","article-title":"Synthesis and antigenic activity of peptides from the Orf3 protein-sequence of hepatitis-E virus.","volume":"21","author":"Semiletov","year":"1995","journal-title":"Bioorg. Khim."},{"key":"B205","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1056\/NEJMoa061847","article-title":"Safety and efficacy of a recombinant hepatitis E vaccine.","volume":"356","author":"Shrestha","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B206","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1073\/pnas.1018878108","article-title":"Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant.","volume":"108","author":"Shukla","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B207","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev.biochem.76.052305.115300","article-title":"Structure and mechanism of helicases and nucleic acid translocases.","volume":"76","author":"Singleton","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"B208","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1128\/JVI.02762-12","article-title":"Genetic variability and the classification of hepatitis E virus.","volume":"87","author":"Smith","year":"2013","journal-title":"J. Virol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1099\/jgv.0.000393","article-title":"Proposed reference sequences for hepatitis E virus subtypes.","volume":"97","author":"Smith","year":"2016","journal-title":"J. Gen. Virol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1099\/vir.0.068429-0","article-title":"Consensus proposals for classification of the family Hepeviridae.","volume":"95","author":"Smith","year":"2014","journal-title":"J. Gen. Virol."},{"issue":"ofw006","key":"B211","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw006","article-title":"Hepatitis E virus infection among solid organ transplant recipients at a North American transplant center.","volume":"3","author":"Sue","year":"2016","journal-title":"Open Forum Infect. Dis."},{"key":"B212","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0167-4781(99)00150-5","article-title":"Morpholino antisense oligomers: the case for an RNase H-independent structural type.","volume":"1489","author":"Summerton","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"B213","doi-asserted-by":"publisher","first-page":"7832","DOI":"10.1128\/JVI.00217-10","article-title":"The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions.","volume":"84","author":"Sun","year":"2010","journal-title":"J. Virol."},{"issue":"245","key":"B214","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-245","article-title":"Lack of processing of the expressed ORF1 gene product of hepatitis E virus.","volume":"8","author":"Suppiah","year":"2011","journal-title":"Virol. J."},{"key":"B215","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1128\/JVI.78.1.320-328.2004","article-title":"The ORF2 protein of hepatitis E virus binds the 5\u2032 region of viral RNA.","volume":"78","author":"Surjit","year":"2004","journal-title":"J. Virol."},{"issue":"7","key":"B216","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-13-7","article-title":"The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells.","volume":"13","author":"Surjit","year":"2012","journal-title":"BMC Biochem."},{"key":"B217","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00705-011-1153-2","article-title":"A549 and PLC\/PRF\/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food.","volume":"157","author":"Takahashi","year":"2012","journal-title":"Arch. Virol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.virol.2004.10.006","article-title":"Complete or near-complete nucleotide sequences of hepatitis E virus genome recovered from a wild boar, a deer, and four patients who ate the deer.","volume":"330","author":"Takahashi","year":"2004","journal-title":"Virology"},{"key":"B219","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1099\/vir.0.029470-0","article-title":"Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype.","volume":"92","author":"Takahashi","year":"2011","journal-title":"J. Gen. Virol."},{"key":"B220","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1128\/JCM.02002-09","article-title":"Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation.","volume":"48","author":"Takahashi","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"B221","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1007\/s00705-008-0179-6","article-title":"Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.","volume":"153","author":"Takahashi","year":"2008","journal-title":"Arch. Virol."},{"key":"B222","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/0042-6822(91)90760-9","article-title":"Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome.","volume":"185","author":"Tam","year":"1991","journal-title":"Virology"},{"key":"B223","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/viro.1996.0001","article-title":"In vitro propagation and production of hepatitis E virus from in vivo-infected primary macaque hepatocytes. Virology","volume":"215","author":"Tam","year":"1996"},{"key":"B224","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1099\/vir.0.82535-0","article-title":"Development and evaluation of an efficient cell-culture system for hepatitis E virus.","volume":"88","author":"Tanaka","year":"2007","journal-title":"J. Gen. Virol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1128\/JCM.00629-09","article-title":"Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5\/15F strain recovered from a fulminant hepatitis patient.","volume":"47","author":"Tanaka","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"B226","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1016\/j.vaccine.2015.05.065","article-title":"A novel linear neutralizing epitope of hepatitis E virus.","volume":"33","author":"Tang","year":"2015","journal-title":"Vaccine"},{"key":"B227","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0140-6736(03)14025-1","article-title":"Zoonotic transmission of hepatitis E virus from deer to human beings.","volume":"362","author":"Tei","year":"2003","journal-title":"Lancet"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311000","article-title":"In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome.","author":"Todt","year":"2016","journal-title":"Gut"},{"key":"B229","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/prot.1107","article-title":"Structured disorder and conformational selection.","volume":"44","author":"Tsai","year":"2001","journal-title":"Proteins"},{"key":"B230","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1073\/pnas.89.2.559","article-title":"Characterization of a prototype strain of hepatitis E virus.","volume":"89","author":"Tsarev","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B231","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1093\/infdis\/168.2.369","article-title":"ELISA for antibody to hepatitis E virus (HEV) based on complete open-reading frame-2 protein expressed in insect cells: identification of HEV infection in primates.","volume":"168","author":"Tsarev","year":"1993","journal-title":"J. Infect. Dis."},{"key":"B232","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1006\/bbrc.2001.5256","article-title":"The full-length and N-terminal deletion of ORF2 protein of hepatitis E virus can dimerize.","volume":"286","author":"Tyagi","year":"2001a","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B233","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1128\/JVI.75.5.2493-2498.2001","article-title":"Self-association and mapping of the interaction domain of hepatitis E virus ORF3 protein.","volume":"75","author":"Tyagi","year":"2001b","journal-title":"J. Virol."},{"key":"B234","doi-asserted-by":"publisher","first-page":"22759","DOI":"10.1074\/jbc.M200185200","article-title":"The phosphorylated form of the ORF3 protein of hepatitis E virus interacts with its non-glycosylated form of the major capsid protein, ORF2.","volume":"277","author":"Tyagi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B235","doi-asserted-by":"publisher","first-page":"12081","DOI":"10.1128\/JVI.79.18.12081-12087.2005","article-title":"The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a kunitz-type serine protease inhibitor.","volume":"79","author":"Tyagi","year":"2005","journal-title":"J. Virol."},{"key":"B236","doi-asserted-by":"publisher","first-page":"29308","DOI":"10.1074\/jbc.M402017200","article-title":"The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin\/bikunin precursor (AMBP) and expedites their export from the hepatocyte.","volume":"279","author":"Tyagi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B237","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1006\/viro.2001.1088","article-title":"Rubella virus DI RNAs and replicons: requirement for nonstructural proteins acting in cis for amplification by helper virus.","volume":"289","author":"Tzeng","year":"2001","journal-title":"Virology"},{"key":"B238","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1212\/WNL.0000000000000111","article-title":"Guillain-Barre syndrome associated with preceding hepatitis E virus infection.","volume":"82","author":"van den Berg","year":"2014","journal-title":"Neurology"},{"key":"B239","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3201\/eid0706.010608","article-title":"Hepatitis E virus sequences in swine related to sequences in humans, The Netherlands.","volume":"7","author":"van der Poel","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"B240","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1212\/WNL.0000000000000112","article-title":"Neuralgic amyotrophy and hepatitis E virus infection.","volume":"82","author":"van Eijk","year":"2014","journal-title":"Neurology"},{"key":"B241","doi-asserted-by":"publisher","first-page":"E838","DOI":"10.1073\/pnas.1218464110","article-title":"Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.","volume":"110","author":"van Kasteren","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"e0133282","key":"B242","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133282","article-title":"A proline-rich domain in the genotype 4 hepatitis E virus ORF3 C-terminus is crucial for downstream V105DLP108 immunoactivity.","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS ONE"},{"key":"B243","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.vaccine.2013.11.064","article-title":"A dual vaccine candidate against norovirus and hepatitis E virus.","volume":"32","author":"Wang","year":"2014a","journal-title":"Vaccine"},{"key":"B244","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.1099\/vir.0.069021-0","article-title":"Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs.","volume":"95","author":"Wang","year":"2014b","journal-title":"J. Gen. Virol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s00705-015-2429-8","article-title":"Analysis of complete genome sequences and a V239A substitution in the helicase domain of swine hepatitis E virus strains isolated in Canada.","volume":"160","author":"Ward","year":"2015","journal-title":"Arch. Virol."},{"key":"B246","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1053\/j.gastro.2012.02.014","article-title":"Pathogenesis and treatment of hepatitis e virus infection.","volume":"142","author":"Wedemeyer","year":"2012","journal-title":"Gastroenterology"},{"key":"B247","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/1096-9071(200007)61:3311::AID-JMV53.0.CO;2-H","article-title":"93G, a novel sporadic strain of hepatitis E virus in South China isolated by cell culture.","volume":"61","author":"Wei","year":"2000","journal-title":"J. Med. Virol."},{"key":"B248","author":"WHO","year":"2015","journal-title":"Hepatitis E [Online]."},{"key":"B249","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3201\/eid2006.140140","article-title":"New hepatitis E virus genotype in camels, the Middle East.","volume":"20","author":"Woo","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"B250","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1099\/0022-1317-81-12-2885","article-title":"Identification of a novel variant of hepatitis E virus in Austria: sequence, phylogenetic and serological analysis.","volume":"81","author":"Worm","year":"2000","journal-title":"J. Gen. Virol."},{"issue":"25735","key":"B251","doi-asserted-by":"publisher","DOI":"10.1038\/srep25735","article-title":"Development and evaluation of two subunit vaccine candidates containing antigens of hepatitis E virus, rotavirus, and astrovirus.","volume":"6","author":"Xia","year":"2016","journal-title":"Sci. Rep."},{"key":"B252","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1155\/S1110724301000262","article-title":"A C-terminal hydrophobic region is required for homo-oligomerization of the hepatitis E virus capsid (ORF2) protein.","volume":"1","author":"Xiaofang","year":"2001","journal-title":"J. Biomed. Biotechnol."},{"key":"B253","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1128\/JVI.00657-10","article-title":"Spatial configuration of hepatitis E virus antigenic domain.","volume":"85","author":"Xing","year":"2011","journal-title":"J. Virol."},{"key":"B254","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1099\/vir.0.010561-0","article-title":"ORF3 protein of hepatitis E virus is essential for virion release from infected cells.","volume":"90","author":"Yamada","year":"2009","journal-title":"J. Gen. Virol."},{"key":"B255","doi-asserted-by":"publisher","first-page":"12986","DOI":"10.1073\/pnas.0903699106","article-title":"Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure.","volume":"106","author":"Yamashita","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B256","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1099\/vir.0.19242-0","article-title":"Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food.","volume":"84","author":"Yazaki","year":"2003","journal-title":"J. Gen. Virol."},{"key":"B257","doi-asserted-by":"publisher","first-page":"4232","DOI":"10.1128\/JVI.02804-15","article-title":"Distinct entry mechanisms for nonenveloped and quasi-enveloped hepatitis E viruses.","volume":"90","author":"Yin","year":"2016","journal-title":"J. Virol."},{"key":"B258","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00894-010-0794-5","article-title":"Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78.","volume":"17","author":"Yu","year":"2011","journal-title":"J. Mol. Model."},{"key":"B259","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1128\/JVI.73.5.4074-4082.1999","article-title":"Mutational analysis of glycosylation, membrane translocation, and cell surface expression of the hepatitis E virus ORF2 protein.","volume":"73","author":"Zafrullah","year":"1999","journal-title":"J. Virol."},{"key":"B260","doi-asserted-by":"crossref","first-page":"9045","DOI":"10.1128\/jvi.71.12.9045-9053.1997","article-title":"The ORF3 protein of hepatitis E virus is a phosphoprotein that associates with the cytoskeleton.","volume":"71","author":"Zafrullah","year":"1997","journal-title":"J. Virol."},{"issue":"RE8","key":"B261","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2003.179.re8","article-title":"The structure and function of proline recognition domains.","volume":"2003","author":"Zarrinpar","year":"2003","journal-title":"Sci. STKE"},{"key":"B262","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.molcel.2009.09.037","article-title":"Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.","volume":"36","author":"Zeng","year":"2009","journal-title":"Mol. Cell"},{"issue":"293","key":"B263","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2032","article-title":"Identification of the 5\u2032 terminal sequence of the SAR-55 and MEX-14 strains of hepatitis E virus and confirmation that the genome is capped.","volume":"65","author":"Zhang","year":"2001","journal-title":"J. Med. Virol."},{"issue":"482","key":"B264","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-482","article-title":"Identification of genotype 4 hepatitis E virus binding proteins on swine liver cells.","volume":"8","author":"Zhang","year":"2011","journal-title":"Virol. J."},{"key":"B265","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1128\/cdli.4.4.423-428.1997","article-title":"Expression, characterization, and immunoreactivities of a soluble hepatitis E virus putative capsid protein species expressed in insect cells.","volume":"4","author":"Zhang","year":"1997","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"B266","doi-asserted-by":"publisher","first-page":"4922","DOI":"10.1016\/j.vaccine.2015.07.040","article-title":"Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission.","volume":"33","author":"Zhang","year":"2015","journal-title":"Vaccine"},{"key":"B267","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1002\/jmv.21536","article-title":"A novel genotype of hepatitis E virus prevalent among farmed rabbits in China.","volume":"81","author":"Zhao","year":"2009","journal-title":"J. Med. Virol."},{"key":"B268","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1099\/vir.0.019323-0","article-title":"Role of heat-shock protein 90 in hepatitis E virus capsid trafficking.","volume":"91","author":"Zheng","year":"2010","journal-title":"J. Gen. Virol."},{"key":"B269","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1016\/j.vaccine.2003.12.017","article-title":"An ELISA for putative neutralizing antibodies to hepatitis E virus detects antibodies to genotypes 1, 2, 3, and 4.","volume":"22","author":"Zhou","year":"2004","journal-title":"Vaccine"},{"key":"B270","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0140-6736(10)61030-6","article-title":"Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial.","volume":"376","author":"Zhu","year":"2010","journal-title":"Lancet"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T17:17:21Z","timestamp":1657214241000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fmicb.2016.01419\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,7]]},"references-count":270,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2016.01419","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,7]]}}}