{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:47:07Z","timestamp":1762004827860},"reference-count":65,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2016.01605","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T08:06:36Z","timestamp":1476432396000},"update-policy":"http:\/\/dx.doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Virulence and Genomic Feature of Multidrug Resistant Campylobacter jejuni Isolated from Broiler Chicken"],"prefix":"10.3389","volume":"7","author":[{"given":"Haihong","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L.","family":"Foley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahid","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guyue","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuhua","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1128\/aac.00304-10","article-title":"Two novel antibiotic resistance genes, tet(44) and ant(6)-Ib, are located within a transferable pathogenicity island in Campylobacter fetus subsp. fetus","volume":"54","author":"Abril","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1099\/00221287-148-4-1203","article-title":"Identification of genetic differences between two Campylobacter jejuni strains with different colonization potentials","volume":"148","author":"Ahmed","year":"2002","journal-title":"Microbiology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1086\/319760","article-title":"Campylobacter jejuni infections: update on emerging issues and trends","volume":"32","author":"Allos","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.micpath.2011.02.009","article-title":"Impact of erythromycin resistance on the virulence properties and fitness of Campylobacter jejuni","volume":"50","author":"Almofti","year":"2011a","journal-title":"Microb. Pathog."},{"key":"B5","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ijfoodmicro.2011.08.002","article-title":"The physiologic and phenotypic alterations due to macrolide exposure in Campylobacter jejuni","volume":"151","author":"Almofti","year":"2011b","journal-title":"Int. J. Food Microbiol."},{"key":"B6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0168-6445(03)00055-X","article-title":"Bacterial iron homeostasis","volume":"27","author":"Andrews","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1574-6968.2007.00893.x","article-title":"Deletion of peb4 gene impairs cell adhesion and biofilm formation in Campylobacter jejuni","volume":"275","author":"Asakura","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"B8","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1099\/00222615-32-4-255","article-title":"A method for detecting Shiga toxin and Shiga-like toxin-I in pure and mixed culture","volume":"32","author":"Ashkenazi","year":"1990","journal-title":"J. Med. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1365-2672.2004.02306.x","article-title":"Evidence for natural horizontal transfer of tetO gene between Campylobacter jejuni strains in chickens","volume":"97","author":"Avrain","year":"2004","journal-title":"J. Appl. Microbiol."},{"key":"B10","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1128\/IAI.70.11.6242-6250.2002","article-title":"DNA sequence and mutational analyses of the pVir plasmid of Campylobacter jejuni 81\u2013176","volume":"70","author":"Bacon","year":"2002","journal-title":"Infect. Immun."},{"key":"B11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1046\/j.1365-2958.2001.02431.x","article-title":"A phase-variable capsule is involved in virulence of Campylobacter jejuni 81\u2013176","volume":"40","author":"Bacon","year":"2001","journal-title":"Mol. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1080\/00365540701242400","article-title":"Association between antimicrobial resistance and virulence genes in Escherichia coli obtained from blood and faeces","volume":"39","author":"Bagger-Skj\u00f8t","year":"2007","journal-title":"Scand. J. Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1126\/science.1138140","article-title":"CRISPR provides acquired resistance against viruses in prokaryotes","volume":"315","author":"Barrangou","year":"2007","journal-title":"Science"},{"key":"B14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/infdis\/157.3.472","article-title":"Experimental Campylobacter jejuni infection in humans","volume":"157","author":"Black","year":"1988","journal-title":"J. Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.vetmic.2009.12.035","article-title":"Prevalence and antimicrobial resistance of Campylobacter isolates in broilers from China","volume":"144","author":"Chen","year":"2010","journal-title":"Vet. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5398","DOI":"10.1128\/AAC.00669-13","article-title":"Whole-genome sequencing of gentamicin-resistant Campylobacter coli isolated from U.S. retail meats reveals novel plasmid-mediated aminoglycoside resistance genes","volume":"57","author":"Chen","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B17","volume-title":"Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals; Approved Standard\u2014Third Edition","author":"CLSI","year":"2008"},{"key":"B18","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/pmic.200700561","article-title":"Identification of membrane-associated proteins from Campylobacter jejuni strains using complementary proteomics technologies","volume":"8","author":"Cordwell","year":"2008","journal-title":"Proteomics"},{"key":"B19","volume-title":"DANMAP 2014 - Use of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Bacteria from Food Animals, Food and Humans in Denmark","author":"DANMAP","year":"2014"},{"key":"B20","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/jac\/dkp179","article-title":"Risk factors for ciprofloxacin-resistant Campylobacter infection in Wales","volume":"64","author":"Evans","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mSphere.00028-15","article-title":"Novel immunomodulatory flagellin-like protein FlaC in Campylobacter jejuni and other campylobacterales","volume":"2","author":"Faber","year":"2015","journal-title":"mSphere"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1128\/JB.01928-07","article-title":"Campylobacter jejuni CsrA mediates oxidative stress responses, biofilm formation, and host cell invasion","volume":"190","author":"Fields","year":"2008","journal-title":"J. Bacteriol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1371\/journal.pbio.0030015","article-title":"Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter species","volume":"3","author":"Fouts","year":"2005","journal-title":"PLoS Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1089\/1076629041310127","article-title":"Characterization of plasmid-mediated aphA-3 kanamycin resistance in Campylobacter jejuni","volume":"10","author":"Gibreel","year":"2004","journal-title":"Microb. Drug Resist."},{"key":"B26","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1128\/IAI.55.10.2526-2530.1987","article-title":"Production of a unique cytotoxin by Campylobacter jejuni","volume":"55","author":"Guerrant","year":"1987","journal-title":"Infect. Immun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.tim.2008.07.002","article-title":"Campylobacter sugars sticking out","volume":"16","author":"Guerry","year":"2008","journal-title":"Trends Microbiol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1128\/IAI.70.2.787-793.2002","article-title":"Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro","volume":"70","author":"Guerry","year":"2002","journal-title":"Infect. Immun."},{"issue":"21","key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00021","article-title":"A fluoroquinolone resistance associated mutation in gyrA Affects DNA supercoiling in Campylobacter jejuni","volume":"2","author":"Han","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1089\/fpd.2009.0339","article-title":"Quantification of mutated alleles of 23S rRNA in macrolide-resistant Campylobacter by TaqMan real-time polymerase chain reaction","volume":"7","author":"Hao","year":"2010","journal-title":"Foodborne Pathog. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1089\/mdr.2009.0008","article-title":"23S rRNA mutation A2074C conferring high-level macrolide resistance and fitness cost in Campylobacter jejuni","volume":"15","author":"Hao","year":"2009","journal-title":"Microb. Drug Resist."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1111\/jam.12793","article-title":"Identification of Campylobacter jejuni and determination of point mutations associated with macrolide resistance using a multiplex TaqMan MGB real-time PCR","volume":"118","author":"Hao","year":"2015","journal-title":"J. Appl. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1128\/AAC.01927-12","article-title":"Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni","volume":"57","author":"Hao","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1086\/428453","article-title":"Adverse health events associated with antimicrobial drug resistance in Campylobacter species: a registry-based cohort study","volume":"191","author":"Helms","year":"2005","journal-title":"J. Infect. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4694","DOI":"10.1128\/IAI.00210-06","article-title":"Unique features of a highly pathogenic Campylobacter jejuni strain","volume":"74","author":"Hofreuter","year":"2006","journal-title":"Infect. Immun."},{"key":"B36","doi-asserted-by":"publisher","first-page":"230","DOI":"10.4161\/viru.23753","article-title":"Resistance mechanisms in Campylobacter jejuni","volume":"4","author":"Iovine","year":"2013","journal-title":"Virulence"},{"key":"B37","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1128\/IAI.01063-07","article-title":"Reactive nitrogen species contribute to innate host defense against Campylobacter jejuni","volume":"76","author":"Iovine","year":"2008","journal-title":"Infect. Immun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e00006","DOI":"10.1128\/genomeA.00006-14","article-title":"Genome sequences of Campylobacter jejuni 81-176 variants with enhanced fitness relative to the parental strain in the chicken gastrointestinal tract","volume":"2","author":"Johnson","year":"2014","journal-title":"Genome Announc"},{"key":"B39","doi-asserted-by":"publisher","first-page":"5549","DOI":"10.1128\/JCM.42.12.5549-5557.2004","article-title":"Differentiation of Campylobacter coli, Campylobacter jejuni, Campylobacter lari, and Campylobacter upsaliensis by a multiplex PCR developed from the nucleotide sequence of the lipid A gene lpxA","volume":"42","author":"Klena","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"B40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1046\/j.1365-2958.1997.4031771.x","article-title":"Identification and molecular cloning of a gene encoding a fibronectin-binding protein (CadF) from Campylobacter jejuni","volume":"24","author":"Konkel","year":"1997","journal-title":"Mol. Microbiol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/infdis\/152.3.592","article-title":"A point-source outbreak of campylobacteriosis associated with consumption of raw milk","volume":"152","author":"Korlath","year":"1985","journal-title":"J. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1139\/o10-141","article-title":"TonB or not TonB: is that the question?","volume":"89","author":"Krewulak","year":"2011","journal-title":"Biochem. Cell Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1089\/mdr.2015.0055","article-title":"Characterization of antimicrobial susceptibility and its association with virulence genes related to adherence, invasion, and cytotoxicity in Campylobacter jejuni and Campylobacter coli isolates from animals, meat, and humans","volume":"22","author":"Lapierre","year":"2016","journal-title":"Microb. Drug Resist."},{"key":"B44","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10096-012-1733-4","article-title":"A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barre syndrome","volume":"32","author":"Louwen","year":"2013","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1042\/BST20130127","article-title":"Are bacteriophage defence and virulence two sides of the same coin in Campylobacter jejuni?","volume":"41","author":"Louwen","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"B46","doi-asserted-by":"publisher","first-page":"189","DOI":"10.2217\/17460913.4.2.189","article-title":"Antibiotic resistance in Campylobacter: emergence, transmission and persistence","volume":"4","author":"Luangtongkum","year":"2009","journal-title":"Future Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1073\/pnas.0408966102","article-title":"Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure","volume":"102","author":"Luo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1003765","DOI":"10.1371\/journal.ppat.1003765","article-title":"CRISPR-Cas immunity against phages: its effects on the evolution and survival of bacterial pathogens","volume":"9","author":"Marraffini","year":"2013","journal-title":"PLoS Pathog."},{"key":"B49","doi-asserted-by":"crossref","first-page":"760","DOI":"10.4315\/0362-028X-71.4.760","article-title":"Antimicrobial resistance and virulence of Enterococcus faecalis isolated from retail food","volume":"71","author":"McGowan-Spicer","year":"2008","journal-title":"J. Food Prot."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1128\/JB.00516-07","article-title":"Campylobacter jejuni biofilms up-regulated in the absence of the stringent response utilize a calcofluor white-reactive polysaccharide","volume":"190","author":"McLennan","year":"2008","journal-title":"J. Bacteriol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s00239-004-0046-3","article-title":"Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements","volume":"60","author":"Mojica","year":"2005","journal-title":"J. Mol. Evol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1099\/mic.0.25820-0","article-title":"Maximal adherence and invasion of INT 407 cells by Campylobacter jejuni requires the CadF outer-membrane protein and microfilament reorganization","volume":"149","author":"Monteville","year":"2003","journal-title":"Microbiology"},{"key":"B53","author":"NARMS","year":"2015","journal-title":"National Antimicrobial Resistance Mornitoring System Integrated Report: 2012-2013"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1086\/423282","article-title":"Prolonged diarrhea due to ciprofloxacin-resistant campylobacter infection","volume":"190","author":"Nelson","year":"2004","journal-title":"J. Infect. Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.micinf.2015.11.007","article-title":"Expression of Mycobacterium tuberculosis NLPC\/p60 family protein Rv0024 induce biofilm formation and resistance against cell wall acting anti-tuberculosis drugs in Mycobacterium smegmatis","volume":"18","author":"Padhi","year":"2016","journal-title":"Microbes Infect."},{"key":"B56","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/35001088","article-title":"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences","volume":"403","author":"Parkhill","year":"2000","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1128\/JB.186.14.4781-4795.2004","article-title":"Identification of Campylobacter jejuni ATCC 43431-specific genes by whole microbial genome comparisons","volume":"186","author":"Poly","year":"2004","journal-title":"J. Bacteriol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1128\/AEM.01878-09","article-title":"Biofilm formation by Campylobacter jejuni is increased under aerobic conditions","volume":"76","author":"Reuter","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"B59","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4615-4143-1_23","article-title":"Secretion of Campylobacter jejuni Cia proteins is contact dependent","volume":"473","author":"Rivera-Amill","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"issue":"37","key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00037","article-title":"CRISPR-Cas systems: new players in gene regulation and bacterial physiology","volume":"4","author":"Sampson","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2164-12-17","article-title":"Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS)","volume":"12","author":"Shimomura","year":"2011","journal-title":"BMC Genomics"},{"key":"B62","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/JCM.33.4.855-859.1995","article-title":"Identification of Campylobacter jejuni on the basis of a species-specific gene that encodes a membrane protein","volume":"33","author":"Stucki","year":"1995","journal-title":"J. Clin. Microbiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1128\/JB.183.8.2553-2559.2001","article-title":"Allelic diversity and recombination in Campylobacter jejuni","volume":"183","author":"Suerbaum","year":"2001","journal-title":"J. Bacteriol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1128\/JB.05753-11","article-title":"Genome sequences of two stress-tolerant Campylobacter jejuni poultry strains, 305 and DFVF1099","volume":"193","author":"Takamiya","year":"2011","journal-title":"J. Bacteriol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1128\/IAI.01021-09","article-title":"Assessment of the duration of protection in Campylobacter jejuni experimental infection in humans","volume":"78","author":"Tribble","year":"2010","journal-title":"Infect. Immun."},{"key":"B66","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1093\/jac\/dkv382","article-title":"Species shift and multidrug resistance of Campylobacter from chicken and swine, China, 2008-14","volume":"71","author":"Wang","year":"2016","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2016.01605\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T17:07:44Z","timestamp":1601140064000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2016.01605\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":65,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2016.01605","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,14]]}}}