{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:40:22Z","timestamp":1791560422221,"version":"4.3.4"},"reference-count":153,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00025","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T03:41:54Z","timestamp":1484883714000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":124,"title":["A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006\u20132016)"],"prefix":"10.3389","volume":"8","author":[{"given":"Mahbobeh","family":"Montazeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahabeddin","family":"Sarvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Mehrzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Ahmadpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Daryani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"B1","first-page":"1","article-title":"Synergistic activity of azithromycin combined with metronidazole against toxoplasmosis in experimental mice","volume":"10","author":"Al-jader","year":"2010","journal-title":"Irq. J. Pharm."},{"key":"B2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jmau.2014.12.001","article-title":"The immunomodulatory effects of rolipram abolish drug-resistant latent phase of Toxoplasma gondii infection in a murine model","volume":"3","author":"Afifi","year":"2015","journal-title":"J. Microsc. Ultrastruct."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.3855\/jidc.4796","article-title":"Toxoplasmosis in immunocompromised patients in Iran: a systematic review and meta-analysis","volume":"8","author":"Ahmadpour","year":"2014","journal-title":"J. Infect. Dev. Ctries."},{"key":"B5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/1756-0500-6-193","article-title":"In vitro evaluation of \u03b2-carboline alkaloids as potential anti-Toxoplasma agents","volume":"6","author":"Alomar","year":"2013","journal-title":"BMC Res. Notes"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e2973","DOI":"10.1371\/journal.pntd.0002973","article-title":"Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis","volume":"8","author":"Andrade","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/1872208311307010002","article-title":"A review of recent patents on the protozoan parasite HSP90 as a drug target","volume":"7","author":"Angel","year":"2013","journal-title":"Recent Pat. Biotechnol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.bmc.2007.09.025","article-title":"Synthesis, anti-Toxoplasma gondii and antimicrobial activities of 2-hydrazolyl-3-phenyl-5-(4-nitrobenzylidene)-4-thiazolidinone substituted derivatives","volume":"30","author":"Aquino","year":"2011","journal-title":"Lat. Am. J. Pharm."},{"key":"B9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0924-8579(92)90002-9","article-title":"Recent advances in the search for new drugs for treatment of toxoplasmosis","volume":"1","author":"Araujo","year":"1992","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B10","doi-asserted-by":"publisher","first-page":"716976","DOI":"10.1155\/2013\/716976","article-title":"Direct effect of two naphthalene-sulfonyl-indole compounds on Toxoplasma gondii tachyzoite","volume":"2013","author":"Asgari","year":"2013","journal-title":"J. Parasitol. Res."},{"key":"B11","first-page":"171","article-title":"Anti-toxoplasma activity of 2-(naphthalene-2-\u03b3lthiol)-1H indole","volume":"10","author":"Asgari","year":"2015","journal-title":"Iran. J. Parasitol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.vetpar.2009.11.017","article-title":"Histomorphometry and macroscopic intestinal lesions in broilers infected with Eimeriaacervulina","volume":"168","author":"Assis","year":"2010","journal-title":"Vet. Parasitol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1128\/AAC.01001-09","article-title":"In vitro and in vivo activities of 1-hydroxy-2-alkyl-4 (1H) quinolone derivatives against Toxoplasma gondii","volume":"54","author":"Bajohr","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.bmc.2005.09.054","article-title":"Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum","volume":"14","author":"Baramee","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.vetpar.2011.12.039","article-title":"Enrofloxacin is able to control Toxoplasma gondii infection in both in vitro and in vivo experimental models","volume":"187","author":"Barbosa","year":"2012","journal-title":"Vet. Parasitol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1128\/AAC.02446-12","article-title":"In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites","volume":"57","author":"Barna","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B17","doi-asserted-by":"publisher","first-page":"6939","DOI":"10.1128\/AAC.01683-15","article-title":"Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis","volume":"59","author":"Benmerzouga","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1590\/S0074-02762009000200038","article-title":"Diagnosis of congenital toxoplasmosis: prenatal and neonatal evaluation of methods used in Toulouse University Hospital and incidence of congenital toxoplasmosis","volume":"104","author":"Bessi\u00e8res","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B20","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0002-9394(02)01537-4","article-title":"A prospective, randomized trial of pyrimethamine and azithromycin vs pyrimethamine and sulfadiazine for the treatment of ocular toxoplasmosis","volume":"134","author":"Bosch-Driessen","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.micpath.2016.04.002","article-title":"Synergistic effects of resveratrol (free and inclusion complex) and sulfamethoxazole-trimetropim treatment on pathology, oxidant\/antioxidant status and behavior of mice infected with Toxoplasma gondii","volume":"95","author":"Bottari","year":"2016","journal-title":"Microb. Pathog."},{"key":"B22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.micpath.2015.01.001","article-title":"Sulfamethoxazole-trimethoprim associated with resveratrol for the treatment of toxoplasmosis in mice: influence on the activity of enzymes involved in brain neurotransmission","volume":"79","author":"Bottari","year":"2015","journal-title":"Microb. Pathog."},{"key":"B23","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.1128\/AAC.02541-14","article-title":"Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica","volume":"58","author":"Boyom","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"B24","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.ijbiomac.2014.11.035","article-title":"Insights into anti-parasitism induced by a C-type lectin from Bothrops pauloensis venom on Toxoplasma gondii","volume":"74","author":"Castanheira","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/1479-5876-12-132","article-title":"Azithromycin is able to control Toxoplasma gondii infection in human villous explants","volume":"12","author":"Castro-Filice","year":"2014","journal-title":"J. Transl. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1002\/cmdc.201600505","article-title":"Activity of fluorine-containing analogues of WC\u22129 and structurally related analogues against two intracellular parasites: Trypanosoma cruzi and Toxoplasma gondii","volume":"11","author":"Chao","year":"2016","journal-title":"ChemMedChem"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1002\/cmdc.201500100","article-title":"Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii","volume":"10","author":"Chao","year":"2015","journal-title":"ChemMedChem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1128\/AAC.05183-11","article-title":"Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis","volume":"56","author":"Chew","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"B29","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1007\/s12272-014-0400-y","article-title":"Evaluation of anti-coccidial effects of 1-[4-(4-nitrophenoxy) phenyl] propane-1-one and identification of its potential target proteins in Toxoplasma gondii","volume":"38","author":"Choi","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exppara.2014.05.002","article-title":"6-trifluoromethyl-2-thiouracil possesses anti-Toxoplasma gondii effect in vitro and in vivo with low hepatotoxicity","volume":"143","author":"Choi","year":"2014","journal-title":"Exp. Parasitol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00253-011-3557-z","article-title":"Exploiting bacterial DNA gyrase as a drug target: current state and perspectives","volume":"92","author":"Collin","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.placenta.2009.08.002","article-title":"Azithromycin inhibits vertical transmission of Toxoplasma gondii in Calomys callosus (Rodentia: Cricetidae)","volume":"30","author":"Costa","year":"2009","journal-title":"Placenta"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1590\/S0103-50532010001000002","article-title":"New approaches to the development of anti-protozoan drug candidates: a review of patents","volume":"21","author":"da Cunha","year":"2010","journal-title":"J. Braz. Chem. Soc."},{"key":"B34","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.parint.2015.08.010","article-title":"Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro","volume":"64","author":"da Silva","year":"2015","journal-title":"Parasitol. Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ejmech.2014.08.046","article-title":"Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii","volume":"86","author":"D'Ascenzio","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1128\/AAC.00337-15","article-title":"Effect of 3-bromopyruvate and atovaquone on infection during in vitro interaction of Toxoplasma gondii and LLC-MK2 cells","volume":"59","author":"de Lima","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0001-706X(03)00194-3","article-title":"Efficacy of azithromycin in a murine toxoplasmosis model, employing a Toxoplasma gondii strain from Turkey","volume":"88","author":"Degerli","year":"2003","journal-title":"Acta Trop."},{"key":"B38","volume-title":"Systematic Search and Analysis of Preclinical Published Data on In vitro and In vivo Activities of Antitoxoplasma Drugs (Panel 2: Treatment Issues)","author":"Derouin","year":"2005"},{"key":"B39","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S0169-4758(00)01667-7","article-title":"Cotrimoxazole for prenatal treatment of congenital toxoplasmosis?","volume":"16","author":"Derouin","year":"2000","journal-title":"Parasitol. Today"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e00042","DOI":"10.1128\/mSphere.00042-15","article-title":"Drug repurposing screening identifies novel compounds that effectively inhibit Toxoplasma gondii growth","volume":"1","author":"Dittmar","year":"2016","journal-title":"mSphere"},{"key":"B41","doi-asserted-by":"publisher","first-page":"15936","DOI":"10.1073\/pnas.1208069109","article-title":"Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis","volume":"109","author":"Doggett","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1128\/AAC.01823-13","article-title":"Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection","volume":"58","author":"Doggett","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"B43","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1039\/c1md00022e","article-title":"Ester prodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies","volume":"2","author":"Dubar","year":"2011","journal-title":"Medchemcomm"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.ijpara.2008.03.007","article-title":"Toxoplasma gondii infection in humans and animals in the United States","volume":"38","author":"Dubey","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"9926","DOI":"10.3390\/molecules19079926","article-title":"1, 4-disubstituted thiosemicarbazide derivatives are potent inhibitors of Toxoplasma gondii proliferation","volume":"19","author":"Dzitko","year":"2014a","journal-title":"Molecules"},{"key":"B46","doi-asserted-by":"publisher","first-page":"7583","DOI":"10.1128\/AAC.03832-14","article-title":"Triazole-based compound as a candidate to develop novel medicines to treat toxoplasmosis","volume":"58","author":"Dzitko","year":"2014b","journal-title":"Antimicrob. Agents Chemother."},{"key":"B47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.exppara.2015.06.005","article-title":"Could miltefosine be used as a therapy for toxoplasmosis?","volume":"157","author":"Eissa","year":"2015","journal-title":"Exp. Parasitol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.actatropica.2014.09.020","article-title":"Preventive prospective of triclosan and triclosan-liposomal nanoparticles against experimental infection with a cystogenic ME49 strain of Toxoplasma gondii","volume":"141","author":"El-Zawawy","year":"2015a","journal-title":"Acta Trop."},{"key":"B49","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.exppara.2014.12.007","article-title":"Triclosan and triclosan-loaded liposomal nanoparticles in the treatment of acute experimental toxoplasmosis","volume":"149","author":"El-Zawawy","year":"2015b","journal-title":"Exp. Parasitol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.1016\/j.bmcl.2010.07.003","article-title":"Synthesis and evaluation of oryzalin analogs against Toxoplasma gondii","volume":"20","author":"Endeshaw","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B51","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.exppara.2012.09.003","article-title":"New naphthoquinones and an alkaloid with in vitro activity against Toxoplasma gondii RH and EGS strains","volume":"132","author":"Ferreira","year":"2012","journal-title":"Exp. Parasitol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.exppara.2005.12.006","article-title":"Toxoplasma gondii: in vitro and in vivo activities of the hydroxynaphthoquinone 2-hydroxy-3-(1\u2032-propen-3-phenyl)-1, 4-naphthoquinone alone or combined with sulfadiazine","volume":"113","author":"Ferreira","year":"2006","journal-title":"Exp. Parasitol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e90203","DOI":"10.1371\/journal.pone.0090203","article-title":"Toxoplasmosis\u2013a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries","volume":"9","author":"Flegr","year":"2014","journal-title":"PLoS ONE"},{"key":"B54","doi-asserted-by":"publisher","first-page":"8375","DOI":"10.1021\/jm3007596","article-title":"Salicylanilide inhibitors of Toxoplasma gondii","volume":"55","author":"Fomovska","year":"2012","journal-title":"J. Med. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00406-013-0413-4","article-title":"Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate","volume":"264","author":"Fond","year":"2014","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.placenta.2011.08.012","article-title":"Azithromycin and spiramycin induce anti-inflammatory response in human trophoblastic (BeWo) cells infected by Toxoplasma gondii but are able to control infection","volume":"32","author":"Franco","year":"2011","journal-title":"Placenta"},{"key":"B57","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.exppara.2014.05.005","article-title":"Chitosan and silver nanoparticles: promising anti-toxoplasma agents","volume":"143","author":"Gaafar","year":"2014","journal-title":"Exp. Parasitol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.arcmed.2013.07.002","article-title":"Effect of nitaxozanide and pyrimethamine on astrocytes infected by Toxoplasma gondii in vitro","volume":"44","author":"Galv\u00e1n-Ram\u00edrez Mde","year":"2013","journal-title":"Arch. Med. Res."},{"key":"B59","first-page":"75","article-title":"The effect of betamethasone and IFN-\u03b3 on replication of Toxoplasma gondii (RH Strain) and nitric oxide production in HeLa cell culture","volume":"5","author":"Ghaffarifar","year":"2006","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1007\/s00044-012-0347-9","article-title":"Evaluating anti-Toxoplasma gondii activity of new serie of phenylsemicarbazone and phenylthiosemicarbazones in vitro","volume":"22","author":"Gomes","year":"2013","journal-title":"Med. Chem. Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1645\/G.E.2536.1","article-title":"Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures","volume":"97","author":"Goodwin","year":"2011","journal-title":"J. Parasitol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1080\/01443610802344332","article-title":"Post-treatment assessment of acute Toxoplasma infection during pregnancy","volume":"28","author":"Habib","year":"2008","journal-title":"J. Obstet. Gynaecol. (Lahore)."},{"key":"B63","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1046\/j.1469-0691.2002.00485.x","article-title":"Toxoplasma gondii: transmission, diagnosis and prevention","volume":"8","author":"Hill","year":"2002","journal-title":"Clin. Microbiol. Infect."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.4315\/0362-028X.JFP-11-417","article-title":"Annual cost of illness and quality-adjusted life year losses in the United States due to 14 foodborne pathogens","volume":"75","author":"Hoffmann","year":"2012","journal-title":"J. Food Protect."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1093\/infdis\/172.6.1561","article-title":"Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease","volume":"172","author":"Howe","year":"1995","journal-title":"J. Infect. Dis."},{"key":"B66","first-page":"1","article-title":"Synthetic retinoid Am80 controls growth of intracellular Toxoplasma by inhibiting acquisition and synthesis of cholesterol in macrophages","volume":"24","author":"Ihara","year":"2014","journal-title":"J. Protozool. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1586\/erv.10.113","article-title":"Vaccination against Toxoplasma gondii: an increasing priority for collaborative research?","volume":"9","author":"Innes","year":"2010","journal-title":"Expert Rev. Vaccines"},{"key":"B68","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.str.2015.02.011","article-title":"Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis","volume":"23","author":"Jain","year":"2015","journal-title":"Structure"},{"key":"B69","doi-asserted-by":"publisher","first-page":"794","DOI":"10.4269\/ajtmh.13-0722","article-title":"Neglected parasitic infections in the United States: toxoplasmosis","volume":"90","author":"Jones","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B70","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ijoa.2010.03.002","article-title":"Side effects of spiramycin masquerading as local anesthetic toxicity during labor epidural analgesia","volume":"19","author":"Julliac","year":"2010","journal-title":"Int. J. Obstet. Anesth."},{"key":"B71","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.exppara.2014.08.008","article-title":"The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection","volume":"145","author":"Kadri","year":"2014","journal-title":"Exp. Parasitol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"5581","DOI":"10.1128\/AAC.00868-12","article-title":"A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii","volume":"56","author":"Kamau","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"B73","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s13071-016-1421-9","article-title":"Dextran sulfate inhibits acute Toxoplama gondii infection in pigs","volume":"9","author":"Kato","year":"2016","journal-title":"Parasit. Vectors"},{"key":"B74","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0166-6851(01)00212-2","article-title":"Optimized expression of green fluorescent protein in Toxoplasma gondii using thermostable green fluorescent protein mutants","volume":"113","author":"Kim","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.bcp.2007.01.026","article-title":"Synthesis, biological evaluation and molecular modeling studies of N 6-benzyladenosine analogues as potential anti-toxoplasma agents","volume":"73","author":"Kim","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"113","DOI":"10.7883\/yoken.JJID.2015.023","volume":"69","author":"K\u00f6ksal","year":"2016","journal-title":"In vivo"},{"key":"B77","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1017\/S0031182011001776","article-title":"The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures","volume":"139","author":"Kropf","year":"2012","journal-title":"Parasitology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.rvsc.2012.08.001","article-title":"In-vivo efficacy of toltrazuril on experimentally induced Toxoplasma gondii tissue cysts in lambs: a novel strategy for prevention of human exposure to meat-borne toxoplasmosis","volume":"94","author":"Kul","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"14182","DOI":"10.1073\/pnas.1208775109","article-title":"Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections","volume":"109","author":"Lai","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1128\/AAC.01236-07","article-title":"Host cells participate in the in vitro effects of novel diamidine analogues against tachyzoites of the intracellular apicomplexan parasites Neospora caninum and Toxoplasma gondii","volume":"52","author":"Leepin","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"B81","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1515\/epoly.2012.12.1.647","article-title":"Effects of nanoparticles in cells infected by Toxoplasma gondii","volume":"12","author":"Leyke","year":"2012","journal-title":"e-Polymers"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e1003665","DOI":"10.1371\/journal.ppat.1003665","article-title":"Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Pathog."},{"key":"B83","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1016\/j.bmcl.2007.07.012","article-title":"Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation","volume":"17","author":"Li\u00f1ares","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1016\/j.ejmech.2010.05.017","article-title":"Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1, 3, 4-thiadiazoles","volume":"45","author":"Liesen","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"B85","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3347\/kjp.2014.52.6.581","article-title":"Recent advances in Toxoplasma gondii immunotherapeutics","volume":"52","author":"Lim","year":"2014","journal-title":"Korean J. Parasitol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.molbiopara.2007.10.012","article-title":"N-linked glycosylation of proteins in the protozoan parasite Toxoplasma gondii","volume":"157","author":"Luk","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/j.1574-6968.2008.01130.x","article-title":"Itraconazole affects Toxoplasma gondii endodyogeny","volume":"282","author":"Martins-Duarte Edos","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"key":"B88","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.exppara.2012.12.011","article-title":"Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model","volume":"133","author":"Martins-Duarte","year":"2013","journal-title":"Exp. Parasitol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e0125705","DOI":"10.1371\/journal.pone.0125705","article-title":"Ciprofloxacin derivatives affect parasite cell division and increase the survival of mice infected with Toxoplasma gondii","volume":"10","author":"Martins-Duarte","year":"2015","journal-title":"PLoS ONE"},{"key":"B90","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.parint.2009.08.004","article-title":"Thiolactomycin analogues as potential anti-Toxoplasma gondii agents","volume":"58","author":"Martins-Duarte","year":"2009","journal-title":"Parasitol. Int."},{"key":"B91","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.exppara.2009.12.011","article-title":"Toxoplasma gondii: fluconazole and itraconazole activity against toxoplasmosis in a murine model","volume":"124","author":"Martins-Duarte","year":"2010","journal-title":"Exp. Parasitol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.vetpar.2010.11.034","article-title":"Evaluation of three novel azasterols against Toxoplasma gondii","volume":"177","author":"Martins-Duarte","year":"2011","journal-title":"Vet. Parasitol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/jac\/dkl180","article-title":"Antiproliferative activities of two novel quinuclidine inhibitors against Toxoplasma gondii tachyzoites in vitro","volume":"58","author":"Martins-Duarte","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"B94","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1128\/AAC.00462-10","article-title":"Activity of the histone deacetylase inhibitor FR235222 on Toxoplasma gondii: inhibition of stage conversion of the parasite cyst form and study of new derivative compounds","volume":"54","author":"Maubon","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B95","doi-asserted-by":"publisher","first-page":"7017","DOI":"10.1128\/AAC.01176-16","article-title":"Review of experimental compounds demonstrating anti-toxoplasma activity","volume":"60","author":"McFarland","year":"2016","journal-title":"Antimicrob. Agents Chemother"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1128\/AAC.01203-07","article-title":"In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone","volume":"52","author":"Meneceur","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"B97","first-page":"2","article-title":"In vitro and in vivo potential effect of the N-acylsulfonamide Bis-oxazolidi-2-ones on Toxoplasma gondii","author":"Meriem","year":"2015","journal-title":"Biomed. Biol. Eng"},{"key":"B98","doi-asserted-by":"publisher","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"B99","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.ejmech.2014.10.057","article-title":"A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity","volume":"89","author":"Moine","year":"2015a","journal-title":"Eur. J. Med. Chem."},{"key":"B100","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ejmech.2015.10.004","article-title":"Development of new highly potent imidazo [1, 2-b] pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1","volume":"105","author":"Moine","year":"2015b","journal-title":"Eur. J. Med. Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"e22572","DOI":"10.5812\/jjm.22572","article-title":"Effect of propranolol alone and in combination with pyrimethamine on acute murine toxoplasmosis","volume":"8","author":"Montazeri","year":"2015","journal-title":"Jundishapur J. Microbiol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"7128","DOI":"10.1128\/AAC.01323-16","article-title":"Evaluation of propranolol effect on experimental acute and chronic toxoplasmosis using quantitative PCR","volume":"60","author":"Montazeri","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"B104","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1590\/S0036-46652013000100012","article-title":"Antiretroviral activity of protease inhibitors against Toxoplasma gondii","volume":"55","author":"Monzote","year":"2013","journal-title":"Rev. Inst. Med. Trop. S. Paulo"},{"key":"B105","doi-asserted-by":"publisher","first-page":"e190","DOI":"10.1371\/journal.pntd.0000190","article-title":"Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo","volume":"2","author":"Mui","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B106","doi-asserted-by":"publisher","first-page":"7161","DOI":"10.1128\/AAC.02009-15","article-title":"Clinically available medicines demonstrating anti-toxoplasma activity","volume":"59","author":"Neville","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B107","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.schres.2013.11.011","article-title":"Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia","volume":"152","author":"Notarangelo","year":"2014","journal-title":"Schizophr. Res."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.2298\/JSC150430063O","article-title":"Tetraoxanes as inhibitors of Apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii and anti-cancer molecules","volume":"80","author":"Opsenica","year":"2015","journal-title":"J. Serb. Chem. Soc"},{"key":"B109","doi-asserted-by":"publisher","first-page":"921","DOI":"10.4236\/ijcm.2014.515124","article-title":"Novel synergistic protective efficacy of atovaquone and diclazuril on fetal-maternal toxoplasmosis","volume":"5","author":"Oz","year":"2014a","journal-title":"Int. J. Clin. Med."},{"key":"B110","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3389\/fmicb.2014.00484","article-title":"Toxoplasmosis complications and novel therapeutic synergism combination of diclazuril plus atovaquone","volume":"5","author":"Oz","year":"2014b","journal-title":"Front. Microbiol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"5817","DOI":"10.1128\/AAC.00873-16","article-title":"Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase","volume":"60","author":"Palencia","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.ijpara.2009.04.003","article-title":"Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis","volume":"39","author":"Pappas","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1007\/s00436-013-3574-1","article-title":"Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice","volume":"112","author":"Payne","year":"2013","journal-title":"Parasitol. Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1586\/14787210.1.1.175","article-title":"Sulfadiazine and pyrimethamine in the postnatal treatment of congenital toxoplasmosis: what are the options?","volume":"1","author":"Petersen","year":"2003","journal-title":"Exp. Rev. Anti-Infect. Ther."},{"key":"B115","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00436-013-3715-6","article-title":"Pyrimethamine-loaded lipid-core nanocapsules to improve drug efficacy for the treatment of toxoplasmosis","volume":"113","author":"Pissinate","year":"2014","journal-title":"Parasitol. Res."},{"key":"B116","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.vetpar.2011.11.008","article-title":"A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro","volume":"186","author":"Portes Jde","year":"2012","journal-title":"Vet. Parasitol."},{"key":"B117","first-page":"1028","article-title":"Use of prednisolone to aid propagation of Toxoplasma gondii in mice","volume":"16","author":"Puvanesuaran","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jsbmb.2006.12.058","article-title":"1, 25 (OH) 2D3 inhibits in vitro and in vivo intracellular growth of apicomplexan parasite Toxoplasma gondii","volume":"103","author":"Rajapakse","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s12639-014-0623-3","article-title":"The inhibitory effect of cromolyn sodium and ketotifen on Toxoplasma gondii entrance into host cells in vitro and in vivo","volume":"40","author":"Rezaei","year":"2014","journal-title":"J. Parasit. Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1007\/s00436-016-4953-1","article-title":"A new type of quinoxalinone derivatives affects viability, invasion, and intracellular growth of Toxoplasma gondii tachyzoites in vitro","volume":"115","author":"Rivera Fern\u00e1ndez","year":"2016","journal-title":"Parasitol. Res."},{"key":"B121","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1517\/13543776.2012.668886","article-title":"New antibacterials for the treatment of toxoplasmosis; a patent review","volume":"22","author":"Rodriguez","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1128\/AAC.00895-06","article-title":"Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4 (1H) quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases","volume":"51","author":"Saleh","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"B123","first-page":"226","article-title":"The effect of fluphenazine and thioridazine on Toxoplasma gondii in vivo","volume":"11","author":"Saraei","year":"2016","journal-title":"Iran. J. Parasitol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"938","DOI":"10.22038\/ijbms.2015.5219","article-title":"In vivo anti-Toxoplasma activity of aripiprazole","volume":"18","author":"Saraei","year":"2015","journal-title":"Iran. J. Basic Med. Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00431-005-1665-4","article-title":"Treatment of infants with congenital toxoplasmosis: tolerability and plasma concentrations of sulfadiazine and pyrimethamine","volume":"165","author":"Schmidt","year":"2006","journal-title":"Eur. J. Pediatr."},{"key":"B126","first-page":"193","article-title":"Congenital toxoplasmosis treatment","volume":"15","author":"Serranti","year":"2011","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3109\/10611861003733995","article-title":"SDS-coated atovaquone nanosuspensions show improved therapeutic efficacy against experimental acquired and reactivated toxoplasmosis by improving passage of gastrointestinal and blood\u2013brain barriers","volume":"19","author":"Shubar","year":"2011","journal-title":"J. Drug Target."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1093\/jac\/dkn047","article-title":"A new combined flow-cytometry-based assay reveals excellent activity against Toxoplasma gondii and low toxicity of new bisphosphonates in vitro and in vivo","volume":"61","author":"Shubar","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"B129","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0002-9394(02)01527-1","article-title":"The effect of long-term intermittent trimethoprim\/sulfamethoxazole treatment on recurrences of toxoplasmic retinochoroiditis","volume":"134","author":"Silveira","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1128\/AAC.01256-06","article-title":"Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii","volume":"51","author":"Smith","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"B131","doi-asserted-by":"publisher","first-page":"639","DOI":"10.5578\/mb.8025","article-title":"[Effects of atovaquone and astragalus combination on the treatment and IL-2, IL-12, IFN-\u03b3 levels on mouse models of acute toxoplasmosis]","volume":"48","author":"S\u00f6nmez","year":"2014","journal-title":"Mikrobiyol. Bul."},{"key":"B132","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1645\/GE-1043R.1","article-title":"Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro","volume":"93","author":"Strobl","year":"2007","journal-title":"J. Parasitol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1645\/GE-1608.1","article-title":"Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent","volume":"95","author":"Strobl","year":"2009","journal-title":"J. Parasitol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1292\/jvms.11-0085","article-title":"1NM-PP1 treatment of mice infected with Toxoplasma gondii","volume":"73","author":"Sugi","year":"2011","journal-title":"J. Vet. Med. Sci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/84612","article-title":"Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of","volume":"7","author":"Surolia","year":"2001","journal-title":"Plasmodium falciparum. Nat. Med."},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.11.007","author":"Szabo","year":"2016","journal-title":"Toxoplasma gondii"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01590-16","article-title":"1. In vitro and in vivo activity of sulfur-containing linear bisphosphonates against apicomplexan parasites","author":"Szajnman","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"B138","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1016\/j.bmc.2007.12.010","article-title":"Synthesis and biological evaluation of 2-alkylaminoethyl-1, 1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase","volume":"16","author":"Szajnman","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1128\/AAC.01059-06","article-title":"Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion","volume":"51","author":"Teo","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"B141","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1021\/jm9017724","article-title":"Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase","volume":"53","author":"Tipparaju","year":"2010","journal-title":"J. Med. Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2471\/BLT.12.111732","article-title":"The global burden of congenital toxoplasmosis: a systematic review","volume":"91","author":"Torgerson","year":"2013","journal-title":"Bull. World Health Organ."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1586\/eri.12.100","article-title":"Toxoplasma histone acetylation remodelers as novel drug targets","volume":"10","author":"Vanagas","year":"2012","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"B144","doi-asserted-by":"publisher","first-page":"6531","DOI":"10.1021\/acs.jmedchem.6b00760","article-title":"Development of an orally available and Central Nervous System (CNS) penetrant Toxoplasma gondii calcium-dependent protein Kinase 1 (Tg CDPK1) inhibitor with minimal human Ether-a-go-go-Related Gene (hERG) activity for the treatment of toxoplasmosis","volume":"59","author":"Vidadala","year":"2016","journal-title":"J. Med. Chem."},{"key":"B145","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1128\/AAC.00680-07","article-title":"Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection","volume":"51","author":"Wei","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1021\/acsmedchemlett.6b00328","article-title":"Discovery of potent and selective leads against Toxoplasma gondii dihydrofolate reductase via structure-based design","volume":"7","author":"Welsch","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"B147","first-page":"15","article-title":"Novel drug compounds against Neospora caninum and Toxoplasma gondii in vitro","volume":"38","author":"Wiengcharoen","year":"2007","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"B148","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.parint.2016.06.013","article-title":"In vitro inhibition of Toxoplasma gondii by the anti-malarial candidate, 6-(1, 2, 6, 7-tetraoxaspiro [7.11] nonadec-4-yl) hexan-1-ol","volume":"65","author":"Xin","year":"2016","journal-title":"Parasitol. Int."},{"key":"B149","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3347\/kjp.2014.52.4.439","article-title":"Gefitinib inhibits the growth of Toxoplasma gondii in HeLa cells","volume":"52","author":"Yang","year":"2014","journal-title":"Korean J. Parasitol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3347\/kjp.2016.54.2.155","article-title":"In vitro and in vivo effects of nitrofurantoin on experimental toxoplasmosis","volume":"54","author":"Yeo","year":"2016","journal-title":"Korean J. Parasitol."},{"key":"B151","first-page":"4325","article-title":"[In vivo effect of dihydroartemisinin and azithromycin on the ultrastructure of Toxoplasma gondii tachyzoites]","volume":"27","author":"Yin","year":"2009","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"key":"B152","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4020-7846-0_3","article-title":"Targeting the Toxoplasma gondii apicoplast for chemotherapy","volume-title":"Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia","author":"Yung","year":"2004"},{"key":"B153","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1586\/14760584.2013.844652","article-title":"Vaccines against Toxoplasma gondii: new developments and perspectives","volume":"12","author":"Zhang","year":"2013","journal-title":"Expert Rev. Vaccines"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1586\/14760584.2015.1098539","article-title":"Recent advances in developing vaccines against Toxoplasma gondii: an update","volume":"14","author":"Zhang","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1128\/AAC.02225-13","article-title":"Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo.","volume":"58","author":"Zhou","year":"2014","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00025\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T08:41:17Z","timestamp":1498380077000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00025\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,20]]},"references-count":153,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00025","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,20]]}}}