{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:54:03Z","timestamp":1792000443929,"version":"4.4.0"},"reference-count":96,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2014 N 1111"],"award-info":[{"award-number":["PICT 2014 N 1111"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"DOI":"10.3389\/fmicb.2017.00256","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T03:32:09Z","timestamp":1487561529000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Brucella and Osteoarticular Cell Activation: Partners in Crime"],"prefix":"10.3389","volume":"8","author":[{"given":"Guillermo H.","family":"Giambartolomei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula C.","family":"Arriola Benitez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Victoria","family":"Delpino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"issue":"R29","key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2936","article-title":"Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors.","volume":"12","author":"Adamopoulos","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/gene.2008.54","article-title":"Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.","volume":"9","author":"Adarichev","year":"2008","journal-title":"Genes Immun."},{"key":"B3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.5144\/0256-4947.1999.403","article-title":"Brucellosis in Saudi Arabia: past, present and future.","volume":"19","author":"Al-Eissa","year":"1999","journal-title":"Ann. Saudi Med."},{"key":"B4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/01.mnm.0000167651.52724.68","article-title":"Scintigraphic findings in osteoarticular brucellosis.","volume":"26","author":"Aydin","year":"2005","journal-title":"Nucl. Med. Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1074\/jbc.275.7.4858","article-title":"Tumor necrosis factor-\u03b1 induces differentiation of and bone resorption by osteoclasts.","volume":"275","author":"Azuma","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis.","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1128\/IAI.73.1.126-134.2005","article-title":"Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.","volume":"73","author":"Behera","year":"2005","journal-title":"Infect. Immun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00223-012-9628-z","article-title":"Deletion of Cx43 from osteocytes results in defective bone material properties but does not decrease extrinsic strength in cortical bone.","volume":"91","author":"Bivi","year":"2012","journal-title":"Calcif. Tissue Int."},{"key":"B9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte.","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"B10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis.","volume":"11","author":"Burrage","year":"2006","journal-title":"Front. Biosci."},{"issue":"e469","key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.06.031","article-title":"Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature.","volume":"14","author":"Buzgan","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha.","volume":"106","author":"Cenci","year":"2000","journal-title":"J. Clin. Invest."},{"key":"B13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00795-015-0099-y","article-title":"The osteocyte plays multiple roles in bone remodeling and mineral homeostasis.","volume":"48","author":"Chen","year":"2015","journal-title":"Med. Mol. Morphol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.abb.2008.04.005","article-title":"Cell-cell communication in the osteoblast\/osteocyte lineage.","volume":"473","author":"Civitelli","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"B15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1086\/525266","article-title":"Clinical findings, therapeutic approach, and outcome of brucellar vertebral osteomyelitis.","volume":"46","author":"Colmenero","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.bone.2006.03.009","article-title":"Immune system and bone metabolism: does thymectomy influence postmenopausal bone loss in humans?","volume":"39","author":"D\u2019Amelio","year":"2006","journal-title":"Bone"},{"key":"B17","first-page":"6","article-title":"The osteoprotegerin\/RANK\/RANKL system: a bone key to vascular disease.","volume":"32 (4 Suppl.)","author":"D\u2019Amelio","year":"2009","journal-title":"J. Endocrinol. Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1189\/jlb.04111185","article-title":"Macrophage-elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2\/MyD88-dependent TNF-alpha production.","volume":"91","author":"Delpino","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jhep.2010.02.028","article-title":"Brucella-infected hepatocytes mediate potentially tissue-damaging immune responses.","volume":"53","author":"Delpino","year":"2010","journal-title":"J. Hepatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1128\/IAI.01259-08","article-title":"Proinflammatory response of human osteoblastic cell lines and osteoblast-monocyte interaction upon infection with Brucella spp.","volume":"77","author":"Delpino","year":"2009","journal-title":"Infect. Immun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1016\/j.injury.2016.10.008","article-title":"The roles of immune cells in bone healing; what we know, do not know and future perspectives.","volume":"47","author":"El-Jawhari","year":"2016","journal-title":"Injury"},{"issue":"R21","key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/ar2613","article-title":"BALB\/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.","volume":"11","author":"Farkas","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"B23","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.178.5.1733","article-title":"Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts.","volume":"178","author":"Fuller","year":"1993","journal-title":"J. Exp. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.2353\/ajpath.2010.090503","article-title":"Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis.","volume":"176","author":"Garcia Samartino","year":"2010","journal-title":"Am. J. Pathol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/35099066","article-title":"Transmembrane crosstalk between the extracellular matrix\u2013cytoskeleton crosstalk.","volume":"2","author":"Geiger","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.ajpath.2012.05.029","article-title":"Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17.","volume":"181","author":"Giambartolomei","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus.","volume":"173","author":"Giambartolomei","year":"2004","journal-title":"J. Immunol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/sj.cdd.4401723","article-title":"Anoikis.","volume":"12(Suppl. 2)","author":"Gilmore","year":"2005","journal-title":"Cell Death Differ."},{"key":"B29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/infdis\/jis310","article-title":"B Lymphocytes provide an infection niche for intracellular bacterium Brucella abortus.","volume":"206","author":"Goenka","year":"2012","journal-title":"J. Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/infdis\/jiq171","article-title":"B cell-deficient mice display markedly enhanced resistance to the intracellular bacterium Brucella abortus.","volume":"203","author":"Goenka","year":"2011","journal-title":"J. Infect. Dis."},{"key":"B31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1286-4579(00)01350-2","article-title":"Immunity and protection against Brucella abortus.","volume":"3","author":"Golding","year":"2001","journal-title":"Microbes Infect."},{"key":"B32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0049-0172(82)90064-6","article-title":"Articular involvement in human brucellosis: a retrospective analysis of 304 cases.","volume":"12","author":"Gotuzzo","year":"1982","journal-title":"Semin. Arthritis Rheum."},{"key":"B33","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.bbrc.2009.09.026","article-title":"Direct effects of osteoprotegerin on human bone cell metabolism.","volume":"389","author":"Grundt","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B34","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00011-004-1303-z","article-title":"Bone lysis and inflammation.","volume":"53","author":"Haynes","year":"2004","journal-title":"Inflamm. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.bone.2010.06.011","article-title":"How B cells influence bone biology in health and disease.","volume":"47","author":"Horowitz","year":"2010","journal-title":"Bone"},{"key":"B36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/rheumatology\/36.3.377","article-title":"Arthritis of shoulder and spinal cord compression due to Brucella disc infection.","volume":"36","author":"Ibero","year":"1997","journal-title":"Br. J. Rheumatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jb\/mvv112","article-title":"The role of osteoclast differentiation and function in skeletal homeostasis.","volume":"159","author":"Ikeda","year":"2016","journal-title":"J. Biochem."},{"key":"B38","first-page":"1291","article-title":"Determinants of synoviocyte clearance of arthritogenic bacteria.","volume":"30","author":"Inman","year":"2003","journal-title":"J. Rheumatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"13028","DOI":"10.1074\/jbc.M115.708578","article-title":"Wnt protein signaling reduces nuclear acetyl-CoA levels to suppress gene expression during osteoblast differentiation.","volume":"291","author":"Karner","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/00365540310017456","article-title":"Brucella infection in total hip replacement: case report and review of the literature.","volume":"36","author":"Kasim","year":"2004","journal-title":"Scand. J. Infect. Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"987","DOI":"10.2353\/ajpath.2006.060180","article-title":"B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease.","volume":"169","author":"Kawai","year":"2006","journal-title":"Am. J. Pathol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1172\/JCI117606","article-title":"Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.","volume":"94","author":"Kitazawa","year":"1994","journal-title":"J. Clin. Invest."},{"key":"B43","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction.","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J. Exp. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/nm1417","article-title":"Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells.","volume":"12","author":"Kollet","year":"2006","journal-title":"Nat. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/1529-0131(200105)44:51003::AID-ANR1793.0.CO;2-","article-title":"Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients.","volume":"44","author":"Kotake","year":"2001","journal-title":"Arthritis Rheum."},{"key":"B47","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/infdis\/jiw087","article-title":"CXCR2 mediates Brucella-induced arthritis in interferon gamma-deficient mice.","volume":"214","author":"Lacey","year":"2016","journal-title":"J. Infect. Dis."},{"issue":"9089610","key":"B48","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9089610","article-title":"The alternative faces of macrophage generate osteoclasts.","volume":"2016","author":"Lampiasi","year":"2016","journal-title":"Biomed Res. Int."},{"key":"B49","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/jbmr.5650080205","article-title":"Tumor necrosis factors alpha and beta can stimulate bone resorption in cultured mouse calvariae by a prostaglandin-independent mechanism.","volume":"8","author":"Lerner","year":"1993","journal-title":"J. Bone Miner. Res."},{"key":"B50","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-59533-2_10","article-title":"\u201cBone and joint imaging,\u201d in","author":"Madkour","year":"2001a","journal-title":"Madkour\u2019s Brucellosis"},{"key":"B51","article-title":"\u201cOsteoarticular brucellosis,\u201d in","author":"Madkour","year":"2001b","journal-title":"Madkour\u2019s Brucellosis"},{"key":"B52","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1242\/dmm.011056","article-title":"Osteoarticular tissue infection and development of skeletal pathology in murine brucellosis.","volume":"6","author":"Magnani","year":"2013","journal-title":"Dis. Model Mech."},{"key":"B53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","article-title":"Tumor necrosis factor-alpha mediates orthopedic implant osteolysis.","volume":"154","author":"Merkel","year":"1999","journal-title":"Am. J. Pathol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00281-004-0188-9","article-title":"Human innate B cells: a link between host defense and autoimmunity?","volume":"26","author":"Milner","year":"2005","journal-title":"Springer Semin. Immunopathol."},{"issue":"720504","key":"B55","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/720504","article-title":"The interplay between the bone and the immune system.","volume":"2013","author":"Mori","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"B56","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.64.7.2371-2380.1996","article-title":"Bacterially induced bone destruction: mechanisms and misconceptions.","volume":"64","author":"Nair","year":"1996","journal-title":"Infect. Immun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.coi.2012.01.014","article-title":"Helper T cell diversity and plasticity.","volume":"24","author":"Nakayamada","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"B58","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1056\/NEJMra050570","article-title":"Brucellosis.","volume":"352","author":"Pappas","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis.","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.micinf.2016.04.001","article-title":"Brucella abortus-infected B cells induce osteoclastogenesis.","volume":"18","author":"Pesce Viglietti","year":"2016","journal-title":"Microbes Infect."},{"key":"B61","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10067-002-8283-6","article-title":"Leukocyte count in the synovial fluid of children with culture-proven brucellar arthritis.","volume":"21","author":"Press","year":"2002","journal-title":"Clin. Rheumatol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.coph.2016.02.003","article-title":"Osteocytes: the master cells in bone remodelling.","volume":"28","author":"Prideaux","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"B63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0950-3579(05)80153-0","article-title":"Bacterial infections: osteoarticular brucellosis.","volume":"9","author":"Rajapakse","year":"1995","journal-title":"Baillieres Clin. Rheumatol."},{"key":"B64","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1462-5822.2005.00570.x","article-title":"Temporal analysis of pathogenic events in virulent and avirulent Brucella melitensis infections.","volume":"7","author":"Rajashekara","year":"2005","journal-title":"Cell Microbiol."},{"key":"B65","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0006-291X(81)80161-1","article-title":"Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2.","volume":"102","author":"Rodan","year":"1981","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B66","doi-asserted-by":"crossref","first-page":"13960","DOI":"10.1073\/pnas.251534698","article-title":"Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo.","volume":"98","author":"Roggia","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.","volume":"203","author":"Sato","year":"2006","journal-title":"J. Exp. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1128\/IAI.00208-12","article-title":"Brucella abortus invasion of osteoblasts inhibits bone formation.","volume":"80","author":"Scian","year":"2012","journal-title":"Infect. Immun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1128\/IAI.05408-11","article-title":"Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases.","volume":"79","author":"Scian","year":"2011a","journal-title":"Infect. Immun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1128\/IAI.00934-10","article-title":"Granulocyte-macrophage colony-stimulating factor- and tumor necrosis factor alpha-mediated matrix metalloproteinase production by human osteoblasts and monocytes after infection with Brucella abortus.","volume":"79","author":"Scian","year":"2011b","journal-title":"Infect. Immun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1128\/IAI.01366-12","article-title":"Brucella abortus invasion of synoviocytes inhibits apoptosis and induces bone resorption through RANKL expression.","volume":"81","author":"Scian","year":"2013","journal-title":"Infect. Immun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S1201-9712(02)90108-6","article-title":"Brucellosis in children: clinical observations in 115 cases.","volume":"6","author":"Shaalan","year":"2002","journal-title":"Int. J. Infect. Dis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1189\/jlb.1211626","article-title":"IFN-gamma-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis.","volume":"92","author":"Skyberg","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"B74","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1600-0765.2006.00888.x","article-title":"Levels of matrix metalloproteinases-8 and -9 with simultaneous presence of periodontal pathogens in gingival crevicular fluid as well as matrix metalloproteinase-9 and cholesterol in blood.","volume":"41","author":"Soder","year":"2006","journal-title":"J. Periodontal Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"401","DOI":"10.4049\/jimmunol.1202286","article-title":"In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1beta-induced peritonitis.","volume":"190","author":"Song","year":"2013","journal-title":"J. Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1242\/jcs.018945","article-title":"Integrins and cell-fate determination.","volume":"122(Pt 2)","author":"Streuli","year":"2009","journal-title":"J. Cell Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nrrheum.2009.217","article-title":"Osteoimmunology and the effects of the immune system on bone.","volume":"5","author":"Takayanagi","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-1-4419-1050-9_7","article-title":"The unexpected link between osteoclasts and the immune system.","volume":"658","author":"Takayanagi","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1172\/JCI116179","article-title":"Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.","volume":"91","author":"Tanaka","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"201","key":"B81","article-title":"Osteoclasts; culprits in inflammatory osteolysis.","volume":"8","author":"Teitelbaum","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"B82","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4049\/jimmunol.138.3.775","article-title":"Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption.","volume":"138","author":"Thomson","year":"1987","journal-title":"J. Immunol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.immuni.2004.05.001","article-title":"Cellular niches controlling B lymphocyte behavior within bone marrow during development.","volume":"20","author":"Tokoyoda","year":"2004","journal-title":"Immunity"},{"key":"B84","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2169\/internalmedicine.50.4700","article-title":"Osteoarticular involvement among 202 brucellosis cases identified in Central Anatolia region of Turkey.","volume":"50","author":"Turan","year":"2011","journal-title":"Intern. Med."},{"key":"B85","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clim.2004.08.019","article-title":"B-lymphocytes, innate immunity, and autoimmunity.","volume":"114","author":"Viau","year":"2005","journal-title":"Clin. Immunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1359\/jbmr.2001.16.12.2222","article-title":"Conditional ablation of the osteoblast lineage in Col2.3deltatk transgenic mice.","volume":"16","author":"Visnjic","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1099\/jmm.0.016360-0","article-title":"Prepatellar bursitis due to Brucella abortus: case report and analysis of the local immune response.","volume":"59(Pt 12)","author":"Wallach","year":"2010","journal-title":"J. Med. Microbiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1172\/JCI23394","article-title":"IL-1 mediates TNF-induced osteoclastogenesis.","volume":"115","author":"Wei","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B89","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL.","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B90","article-title":"\u201cClinical manifestations of human brucellosis,\u201d in","author":"Young","year":"1989","journal-title":"Brucellosis: Clinical and Laboratory Aspects"},{"key":"B91","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s15010-008-8090-3","article-title":"Family studies in brucellosis.","volume":"36","author":"Young","year":"2008","journal-title":"Infection"},{"key":"B92","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/IAI.63.2.720-723.1995","article-title":"Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro.","volume":"63","author":"Zhan","year":"1995a","journal-title":"Infect. Immun."},{"key":"B93","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1128\/IAI.63.4.1387-1390.1995","article-title":"Endogenous interleukin-12 is involved in resistance to Brucella abortus infection.","volume":"63","author":"Zhan","year":"1995b","journal-title":"Infect. Immun."},{"key":"B94","first-page":"458","article-title":"Cytokine production in the murine response to brucella infection or immunization with antigenic extracts.","volume":"80","author":"Zhan","year":"1993","journal-title":"Immunology"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1359\/jbmr.2002.17.11.2068","article-title":"MLO-Y4 osteocyte-like cells support osteoclast formation and activation.","volume":"17","author":"Zhao","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.micinf.2009.04.010","article-title":"Brucella abortus activates human neutrophils.","volume":"11","author":"Zwerdling","year":"2009","journal-title":"Microbes Infect."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00256\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:28:29Z","timestamp":1692692909000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fmicb.2017.00256\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,20]]},"references-count":96,"URL":"https:\/\/doi.org\/10.3389\/fmicb.2017.00256","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,20]]}}}